INT78960

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.56
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
tail 1
nucleus 1
platelet 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 93 98.76 Very High Very High Very High
aspirin 11 98.16 Very High Very High Very High
opioid receptor 5 97.84 Very High Very High Very High
Enkephalin 1 91.28 High High
fibrosis 212 87.04 High High
Inflammation 97 86.64 High High
Opioid 1 82.56 Quite High
metalloproteinase 15 71.20 Quite High
corticosteroid 37 67.00 Quite High
cINOD 4 63.92 Quite High
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 92.52 High High
Thymoma 1 89.68 High High
Pulmonary Fibrosis 136 87.04 High High
INFLAMMATION 119 86.64 High High
Apoptosis 97 82.32 Quite High
Injury 39 80.00 Quite High
Neurodegenerative Disease 8 78.84 Quite High
Cancer 13 76.80 Quite High
Severe Combined Immunodeficiency 1 76.80 Quite High
Leukemia 2 72.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we demonstrate that another member of the STAT family, STAT5B, associates constitutively with the C-terminal tail of the delta-opioid receptor (delta-CT).
STAT Binding (associates) of in tail associated with opioid receptor
1) Confidence 0.36 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20433855 Disease Relevance 0 Pain Relevance 0.44
Both the receptor and JAK2 protein are phosphorylated, and signal transducers and activators of transcription (STAT) proteins bind to this complex.
STAT Binding (bind) of
2) Confidence 0.12 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.06 Pain Relevance 0.04
The activation of the signal transducer and activator of transcription (STAT) pathway by leptin was then monitored using an ELISA-based kit specific for STAT 1?
STAT Binding (specific) of
3) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.06 Pain Relevance 0
After ligand binding, STAT proteins are recruited to the cytokine receptors and phosphorylated on tyrosine residues by Janus tyrosine kinases (Jaks) [76].
STAT Binding (binding) of associated with cytokine
4) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.10
The pharmacodynamic studies show that these O-acyl derivatives of salicylic acid and diflunisal probably bind to, or combine with, the same site on the platelet cyclooxygenase as aspirin.
O-acyl Binding (bind) of in platelet associated with aspirin
5) Confidence 0.03 Published 1998 Journal J. Lab. Clin. Med. Section Abstract Doc Link 9851736 Disease Relevance 0.30 Pain Relevance 0.39
Stimulation of JAK-3, a cytoplasmic tyrosine kinase, leads to dimerization of STAT 5 transcription factor which is specific for the IL-2 family of cytokines and hence make this a potential target for immunosuppressive drugs [128].
STAT Binding (dimerization) of associated with cytokine
6) Confidence 0.03 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.15 Pain Relevance 0.29
The rate of transcription of target genes is then modified by binding of activated STAT dimers to a DNA element in the promoter region.
STAT Binding (binding) of
7) Confidence 0.03 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.07 Pain Relevance 0.17
The STAT proteins then homo-or heterodimerize and translocate to the nucleus, where they bind to DNA and modulate gene expression.
STAT Binding (heterodimerize) of in nucleus
8) Confidence 0.03 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.78 Pain Relevance 0.27
STAT family members bind with varying affinities to a canonical palindromic sequence (TTCN2-4GAA) in the promoters of their target genes [89].
STAT Binding (bind) of
9) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.74 Pain Relevance 0.23
Apigenin and luteolin appear to affect the phosphorylation status of tyrosine 701 and serine 727, which is required for STAT dimerization and maximal activation of transcription, respectively [53,54].
STAT Binding (dimerization) of
10) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.30 Pain Relevance 0

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