INT78974

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Context Info
Confidence 0.31
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg, Prkaca) plasma membrane (Prkcg, Prkaca) nucleus (Prkcg, Prkaca)
cytoplasm (Prkcg, Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Anatomy Link Frequency
amygdala 1
Prkcg (Rattus norvegicus)
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 11 100.00 Very High Very High Very High
amygdala 97 99.42 Very High Very High Very High
Pain 69 98.72 Very High Very High Very High
Glutamate receptor 3 98.16 Very High Very High Very High
Neurotransmitter 1 97.08 Very High Very High Very High
Neuropeptide 3 95.52 Very High Very High Very High
nMDA receptor 43 82.68 Quite High
long-term potentiation 4 74.52 Quite High
Action potential 3 69.56 Quite High
tetrodotoxin 1 64.88 Quite High
Disease Link Frequency Relevance Heat
Pain 69 98.72 Very High Very High Very High
Nociception 6 71.84 Quite High
Arthritis 63 49.20 Quite Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Investigating the interaction between PKC and PKA revealed that although inhibitors of PKA had little effect on PKC-induced modulation of TTX-R INa, inhibitors of PKC significantly attenuated PKA-induced modulation of the current.
PKC Binding (interaction) of PKA associated with kinase c
1) Confidence 0.31 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.07 Pain Relevance 0.55
A variety of neuromodulator/neurotransmitter receptors, including metabotropic glutamate receptors that are important for pain-related plasticity in the amygdala [12,16], have been shown to couple to ERK activation via PKA and PKC [61].
PKC Binding (couple) of PKA in amygdala associated with pain, neurotransmitter, glutamate receptor and amygdala
2) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.28 Pain Relevance 0.86

General Comments

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