INT7899

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 41
Total Number 44
Disease Relevance 7.29
Pain Relevance 25.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
striatum 9
neurons 9
hippocampus 8
nucleus accumbens 5
plasma 4
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 155 100.00 Very High Very High Very High
Hippocampus 109 100.00 Very High Very High Very High
antagonist 87 100.00 Very High Very High Very High
cocaine 44 100.00 Very High Very High Very High
opioid receptor 18 100.00 Very High Very High Very High
nMDA receptor 36 99.98 Very High Very High Very High
dopamine receptor 23 99.98 Very High Very High Very High
depression 14 99.96 Very High Very High Very High
Analgesic 42 99.78 Very High Very High Very High
Anterior cingulate cortex 199 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 78 100.00 Very High Very High Very High
Amputation 1 99.98 Very High Very High Very High
Depression 14 99.96 Very High Very High Very High
Colitis 5 99.96 Very High Very High Very High
Targeted Disruption 51 99.82 Very High Very High Very High
Injury 7 99.58 Very High Very High Very High
Pain 63 99.22 Very High Very High Very High
Infection 6 99.12 Very High Very High Very High
Schizophrenia 3 98.52 Very High Very High Very High
INFLAMMATION 9 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we observed that targeted gene transfer of Homer1a to specific spinal segments in vivo reduces inflammatory hyperalgesia.
Positive_regulation (transfer) of Gene_expression (transfer) of Homer1a in spinal associated with hyperalgesia and inflammation
1) Confidence 0.70 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16715092 Disease Relevance 0.89 Pain Relevance 1.06
Vesl-1S overexpression by in vivo AAV virus infection in rat hippocampus leads to impaired ability in the water maze test [22].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Vesl-1S in hippocampus associated with hippocampus and infection
2) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.25 Pain Relevance 0.16
Western blot analysis revealed that the level of Vesl-1L protein did not increase after the application of a maximum electroconvulsive shock (MECS) in the hippocampus of KO mice and was comparable to that of wild type mice in the condition where the level of Vesl-1S protein was increased (Figure 2c).
Neg (not) Positive_regulation (increase) of Gene_expression (protein) of Vesl-1L in hippocampus associated with shock and hippocampus
3) Confidence 0.50 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.20 Pain Relevance 0.11
Western blot analysis revealed that the level of Vesl-1L protein did not increase after the application of a maximum electroconvulsive shock (MECS) in the hippocampus of KO mice and was comparable to that of wild type mice in the condition where the level of Vesl-1S protein was increased (Figure 2c).
Positive_regulation (increased) of Gene_expression (protein) of Vesl-1L in hippocampus associated with shock and hippocampus
4) Confidence 0.50 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.25 Pain Relevance 0.12
No change in opioid binding sites or in morphine-induced analgesia was observed in these mutant mice, and the increase of adenylyl cyclase activity and immediate early gene expression after morphine withdrawal was normal.
Positive_regulation (increase) of Gene_expression (expression) of immediate early gene associated with withdrawal, opioid, analgesia and morphine
5) Confidence 0.43 Published 1996 Journal Science Section Abstract Doc Link 8662559 Disease Relevance 0 Pain Relevance 1.04
Previous studies demonstrated that acute irritation of the lower urinary tract (LUT) induces the expression of the immediate early gene, c-fos, in lumbo-sacral spinal cord neurons "J.
Positive_regulation (induces) of Gene_expression (expression) of immediate early gene in lower urinary tract associated with spinal cord
6) Confidence 0.39 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11684339 Disease Relevance 0 Pain Relevance 0.20
Oxytocin neurones were activated during birth as shown by both increased immediate early gene ( Fos) expression in oxytocin neurones in the supraoptic nucleus and increased plasma oxytocin concentrations during birth.
Positive_regulation (increased) of Gene_expression (expression) of immediate early gene in plasma
7) Confidence 0.28 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.13 Pain Relevance 0.10
D1R mutants do not become locomotor activated with cocaine or show upregulated immediate early gene (IEG) expression, but D2 receptor-dependent IEG changes are intact.
Positive_regulation (upregulated) of Gene_expression (expression) of immediate early gene associated with cocaine
8) Confidence 0.24 Published 1998 Journal Dev. Neurosci. Section Abstract Doc Link 9691193 Disease Relevance 0.12 Pain Relevance 0.60
Oxytocin neurones were activated during birth as shown by both increased immediate early gene ( Fos) expression in oxytocin neurones in the supraoptic nucleus and increased plasma oxytocin concentrations during birth.
Positive_regulation (increased) of Gene_expression (expression) of immediate early gene in plasma
9) Confidence 0.20 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.13 Pain Relevance 0.10
Besides producing pain behavior, hind paw formalin injection induces the expression of the immediate-early gene, c-fos.
Positive_regulation (induces) of Gene_expression (expression) of immediate-early gene in paw associated with pain
10) Confidence 0.19 Published 2002 Journal J Pain Section Abstract Doc Link 14622771 Disease Relevance 0.56 Pain Relevance 0.35
Previous studies have revealed that chemical irritation of the urinary bladder and urethral mucosa increases the expression of the immediate-early gene, c-fos, in the lumbosacral spinal cord of the rat.
Positive_regulation (increases) of Gene_expression (expression) of immediate-early gene in spinal cord associated with spinal cord
11) Confidence 0.16 Published 1998 Journal Somatosens Mot Res Section Abstract Doc Link 9583573 Disease Relevance 0.09 Pain Relevance 0.35
To do this we examined the expression of c-fos, an immediate early gene that is an indicator of neural activity and whose expression is significantly increased in the CA1 region of the hippocampus following context fear conditioning [39], [47], [48], [49], [50].
Positive_regulation (increased) of Gene_expression (expression) of immediate early gene in hippocampus associated with anxiety disorder and hippocampus
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.42 Pain Relevance 0.19
Tissue injury or digit amputation activates immediate early gene expression and triggers long-term potentiation of evoked sensory responses in the ACC [27-29].
Positive_regulation (activates) of Gene_expression (expression) of immediate early gene in digit associated with injury, amputation, long-term potentiation and anterior cingulate cortex
13) Confidence 0.09 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074356 Disease Relevance 0.70 Pain Relevance 0.84
Neonates of both lines had higher expression than the adults, which likely reflects increased immediate-early gene expression during development.
Positive_regulation (increased) of Gene_expression (expression) of immediate-early gene
14) Confidence 0.09 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.77 Pain Relevance 0.13
DISCUSSION: Several hypotheses have been proposed, including selective delta and c-nerve fiber destruction, upregulation of intermediate early gene expression (IEG) and increase in c-fos protein that modulated pain transmission.
Positive_regulation (upregulation) of Gene_expression (expression) of intermediate early gene in nerve
15) Confidence 0.08 Published 2006 Journal Pain Physician Section Body Doc Link 16703977 Disease Relevance 0 Pain Relevance 0
Furthermore, when rats were exposed to an environment where they were previously allowed to self administer cocaine, immediate early gene expression, indicative of neuronal activity, was increased in the ACC [51].
Positive_regulation (increased) of Gene_expression (expression) of immediate early gene in neuronal associated with anterior cingulate cortex and cocaine
16) Confidence 0.08 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.14 Pain Relevance 1.52
Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity.
Positive_regulation (enhances) of Gene_expression (expression) of immediate early gene associated with enkephalin and cocaine
17) Confidence 0.06 Published 2006 Journal Neuropsychopharmacology Section Title Doc Link 16407894 Disease Relevance 0.10 Pain Relevance 0.45
These results suggest that the responses to both morphine and N-methyl-D-aspartate receptor antagonists differ between the sexes and emphasize that glutamate is involved in morphine-induced immediate early gene expression in the brain.
Positive_regulation (induced) of Gene_expression (expression) of immediate early gene in brain associated with glutamate, antagonist, nmda receptor and morphine
18) Confidence 0.05 Published 1999 Journal Neuroscience Section Abstract Doc Link 10501478 Disease Relevance 0.07 Pain Relevance 0.89
Cellular expression of the protein product of the immediate early gene, c-fos, was dramatically increased in the nucleus accumbens shell after ventral hippocampal N-methyl-D-aspartate infusion, and haloperidol, SCH-23390 and reserpine attenuated this effect.
Positive_regulation (increased) of Gene_expression (product) of immediate early gene in shell associated with nucleus accumbens
19) Confidence 0.04 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613497 Disease Relevance 0 Pain Relevance 1.01
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neurons.
Positive_regulation (induced) of Gene_expression (expression) of immediate-early gene in neurons associated with antagonist, dopamine receptor and enkephalin
20) Confidence 0.03 Published 1999 Journal Neuroscience Section Title Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.63

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