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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.68
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
macrophage 2
chondrocytes 2
intermediary 2
phagocytes 2
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 87 100.00 Very High Very High Very High
Inflammatory mediators 16 98.64 Very High Very High Very High
cytokine 52 98.36 Very High Very High Very High
cINOD 85 92.24 High High
Inflammatory response 19 92.00 High High
rheumatoid arthritis 14 90.00 High High
Inflammation 154 87.72 High High
Arthritis 8 74.88 Quite High
agonist 8 65.44 Quite High
antagonist 6 52.88 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 94 100.00 Very High Very High Very High
INFLAMMATION 203 98.24 Very High Very High Very High
Sepsis 27 92.00 High High
Rheumatoid Arthritis 14 90.00 High High
Death 8 89.76 High High
Leptospirosis 67 84.48 Quite High
Sprains And Strains 11 76.88 Quite High
Arthritis 10 74.88 Quite High
Disease 41 72.32 Quite High
Obesity 1 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Regulation (effects) of Gene_expression (expression) of iNOS in chondrocytes associated with osteoarthritis
1) Confidence 0.43 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.38 Pain Relevance 0.24
Most human cells that are capable of iNOS expression require multiple synergistically active cytokines to induce NO synthesis.
Regulation (capable) of Gene_expression (expression) of iNOS associated with cytokine
2) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 1.14 Pain Relevance 0.56
Figure 2d shows the effects of various inhibitors on iNOS expression, as determined by western blot analysis of cell extracts.
Regulation (effects) of Gene_expression (expression) of iNOS
3) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
In these studies, receptor regulated expression of COX-2 and iNOS was dependent upon the intermediary phosphorylation of ERK.
Regulation (regulated) of Gene_expression (expression) of iNOS in intermediary
4) Confidence 0.18 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.32 Pain Relevance 0.19
Since NO is one of the inflammatory mediators, the inhibition of NO by the extracts of edible plants has been reported.60 Using LPS/cytokine-treated macrophages or macrophage-like cell lines, quercetin was found to inhibit the production of NO.61 However, mechanism studies have shown that compounds down-regulate iNOS expression, which subsequently results in reducing the amount of NO production.
Regulation (regulate) of Gene_expression (expression) of iNOS in macrophage associated with inflammatory mediators and cytokine
5) Confidence 0.04 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.46 Pain Relevance 0.27
is believed to be important in the regulation of the immune system by regulatory T cells; it notably acts by blocking the activation of lymphocyte- and monocyte-derived phagocytes and by controlling iNOS expression [28].
Regulation (controlling) of Gene_expression (expression) of iNOS in phagocytes
6) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797601 Disease Relevance 1.40 Pain Relevance 0.43

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