INT79196

Context Info Confidence 0.39 First Reported 1999 Last Reported 2003 Negated 3 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.50 Pain Relevance 2.01

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)

Ntsr1 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 4 100.00 analgesia 9 98.56 Neuropeptide 4 95.84 Intracerebroventricular 3 92.32 Analgesic 8 89.68 tetrodotoxin 1 89.36 Potency 1 88.88 agonist 2 81.76 Glutamate 2 78.16 narcan 1 76.92

Disease Link Frequency Relevance Heat Body Weight 2 95.60 Hypothermia 2 91.80 Congenital Anomalies 2 74.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NT-1R(-/-) mice showed similar spontaneous locomotion to the control littermates, but did not respond to i.c.v.

Neg (not) Regulation (respond) of NT-1R

1) Confidence 0.39 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384239 Disease Relevance 0.26 Pain Relevance 0.39

However, neither an NTR1 antagonist, SR48692, an NTR2 antagonist, levocabastine, nor the two combined affected the basal level and the neurotensin-mediated decrease in DARPP-32 Thr75 phosphorylation.

Regulation (affected) of NTR1 associated with antagonist

2) Confidence 0.39 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.44

I.c.v. injection of NT inhibited feeding in fasted wild-type mice, but had no effect on feeding of the NT-1R(-/-) mice.

Neg (no) Regulation (effect) of NT-1R

3) Confidence 0.27 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384239 Disease Relevance 0.24 Pain Relevance 0.39

This effect was specific, because NTR1 levels were unaffected, and sense or scramble oligodeoxynucleotides had no effect.

Neg (unaffected) Regulation (unaffected) of NTR1

4) Confidence 0.25 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9870978 Disease Relevance 0 Pain Relevance 0.79

General Comments

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