INT79450

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.60
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4B) signal transduction (PDE4B) nucleus (PDE4B)
cytoplasm (PDE4B)
Anatomy Link Frequency
monocytes 4
myometrium 2
PDE4B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 95.08 Very High Very High Very High
agonist 5 80.48 Quite High
cytokine 5 75.84 Quite High
cINOD 5 70.48 Quite High
Inflammatory response 1 34.32 Quite Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 95.08 Very High Very High Very High
Disease 1 94.12 High High
Hypertension 2 87.00 High High
Reprotox - General 2 2 85.88 High High
Premature Birth 9 49.36 Quite Low
Dysmenorrhea 1 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Very recently, we found in monocytes that PDE4B gene expression is selectively induced by lipopolysaccharide (LPS) and that the induction is inhibited by interleukin (IL)-10 and IL-4.
Positive_regulation (induced) of Gene_expression (expression) of PDE4B in monocytes
1) Confidence 0.50 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10385698 Disease Relevance 0.09 Pain Relevance 0.05
In the present study, we demonstrate, for the first time, that lipopolysaccharide (LPS) significantly and selectively stimulated PDE4B mRNA production in human monocytes.
Positive_regulation (stimulated) of Gene_expression (production) of PDE4B in monocytes
2) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9882697 Disease Relevance 0 Pain Relevance 0
Interestingly, unlike LPS induction, the dibutyryl-cAMP induction of PDE4B mRNA expression was not inhibited by IL-10.
Positive_regulation (induction) of Gene_expression (expression) of PDE4B
3) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9882697 Disease Relevance 0 Pain Relevance 0.07
PDE4B mRNA expression was also stimulated by dibutyryl-cAMP.
Positive_regulation (stimulated) of Gene_expression (expression) of PDE4B
4) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9882697 Disease Relevance 0 Pain Relevance 0.06
We also demonstrate that LPS induction of PDE4B mRNA expression was inhibited strongly by interleukin (IL)-10.
Positive_regulation (induction) of Gene_expression (expression) of PDE4B
5) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9882697 Disease Relevance 0 Pain Relevance 0
Because of their myorelaxant properties, we first examined their expression in human myometrium and uncover an increased expression of one specific isoform, PDE4B2, in the near-term myometrium as compared to myometrium in the nonpregnant state.
Positive_regulation (increased) of Gene_expression (expression) of PDE4B2 in myometrium
6) Confidence 0.45 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1892053 Disease Relevance 0.51 Pain Relevance 0.23

General Comments

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