INT79460

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 2.72
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
ganglion cells 3
fat cells 3
HSF 2
muscle 1
amacrine cells 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 292 100.00 Very High Very High Very High
Morphine 79 99.98 Very High Very High Very High
agonist 63 99.98 Very High Very High Very High
fluoxetine 7 99.98 Very High Very High Very High
Glutamate 27 97.28 Very High Very High Very High
opioid receptor 86 97.20 Very High Very High Very High
substance P 20 93.72 High High
mu opioid receptor 3 92.96 High High
nMDA receptor 55 92.68 High High
Nerve growth factor 56 90.80 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Obesity 98 99.04 Very High Very High Very High
Death 13 97.84 Very High Very High Very High
Apoptosis 6 92.24 High High
Hyperplasia 1 88.52 High High
Pain 27 86.92 High High
Coagulation Disorder 8 86.64 High High
INFLAMMATION 53 86.56 High High
Injury 17 82.72 Quite High
Stress 6 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that fluoxetine increased PKC translocation obtained with 1 microg/mL Con A concentration, whereas PKC was degraded when 2 microg/mL was used.
Positive_regulation (increased) of Localization (translocation) of PKC associated with fluoxetine
1) Confidence 0.70 Published 1998 Journal Cell. Signal. Section Abstract Doc Link 9884023 Disease Relevance 0.09 Pain Relevance 0.61
mediates granule secretion (19), that PKC?
Positive_regulation (mediates) of Localization (secretion) of PKC associated with kinase c
2) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.13 Pain Relevance 0.66
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Neg (not) Positive_regulation (not) of Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts
3) Confidence 0.27 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.18 Pain Relevance 0.16
Another study suggests that activation of PKC (translocation of PKCdelta) by GGA plays a role in mediating HSF translocation [24].
Positive_regulation (activation) of Localization (translocation) of PKC in HSF
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.97 Pain Relevance 0.03
In a previous study, we reported that morphine promotes the recruitment of PKC?
Positive_regulation (promotes) of Localization (recruitment) of PKC associated with kinase c and morphine
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 1.14
Other proteases known to activate PAR1 and PAR4 were also effective in causing translocation of PKC?
Positive_regulation (causing) of Localization (translocation) of PKC
6) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.05 Pain Relevance 0.22
PAR2-AP was ineffective in causing translocation of PKC?
Positive_regulation (causing) of Localization (translocation) of PKC
7) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.11
, which can be observed as a translocation of PKC?
Positive_regulation (observed) of Localization (translocation) of PKC
8) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.52 Pain Relevance 0.20
PAR1/4 agonists cause translocation of PKC-?
Positive_regulation (cause) of Localization (translocation) of PKC associated with agonist
9) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.08 Pain Relevance 0.27
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Neg (not) Positive_regulation (not) of in amacrine cells Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts
10) Confidence 0.09 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.18 Pain Relevance 0.16
In this model, when AA is released in the presence of PKC activating-cofactors (DAG and Ca2+), AA facilitates activation of PKC and excitatory conditioning changes (reductions in K+ currents, enhanced light response, and spiking).
Positive_regulation (activation) of Localization (released) of PKC associated with kinase c
11) Confidence 0.08 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0.30
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of Localization (translocation) of PKC in fat cells associated with kinase c and obesity
12) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
OFQ/N pretreatment resulted in translocation of PKC-alpha, G protein-coupled receptor kinase 2 (GRK2) and GRK3 from the cytosol to the membrane, and this translocation was also blocked by chelerythrine.
Positive_regulation (resulted) of Localization (translocation) of PKC-alpha
13) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130708 Disease Relevance 0 Pain Relevance 0.66
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of in muscle Localization (translocation) of PKC in fat cells associated with kinase c and obesity
14) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10

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