INT79460

Context Info Confidence 0.70 First Reported 1998 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 11 Total Number 14 Disease Relevance 2.72 Pain Relevance 4.71

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca) protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)

Anatomy Link Frequency ganglion cells 3 fat cells 3 HSF 2 muscle 1 amacrine cells 1 Prkca (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 292 100.00 Morphine 79 99.98 agonist 63 99.98 fluoxetine 7 99.98 Glutamate 27 97.28 opioid receptor 86 97.20 substance P 20 93.72 mu opioid receptor 3 92.96 nMDA receptor 55 92.68 Nerve growth factor 56 90.80

Disease Link Frequency Relevance Heat Ganglion Cysts 7 100.00 Obesity 98 99.04 Death 13 97.84 Apoptosis 6 92.24 Hyperplasia 1 88.52 Pain 27 86.92 Coagulation Disorder 8 86.64 INFLAMMATION 53 86.56 Injury 17 82.72 Stress 6 78.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We observed that fluoxetine increased PKC translocation obtained with 1 microg/mL Con A concentration, whereas PKC was degraded when 2 microg/mL was used.

Positive_regulation (increased) of Localization (translocation) of PKC associated with fluoxetine

1) Confidence 0.70 Published 1998 Journal Cell. Signal. Section Abstract Doc Link 9884023 Disease Relevance 0.09 Pain Relevance 0.61

mediates granule secretion (19), that PKC?

Positive_regulation (mediates) of Localization (secretion) of PKC associated with kinase c

2) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.13 Pain Relevance 0.66

We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?

Neg (not) Positive_regulation (not) of Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts

3) Confidence 0.27 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.18 Pain Relevance 0.16

Another study suggests that activation of PKC (translocation of PKCdelta) by GGA plays a role in mediating HSF translocation [24].

Positive_regulation (activation) of Localization (translocation) of PKC in HSF

4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.97 Pain Relevance 0.03

In a previous study, we reported that morphine promotes the recruitment of PKC?

Positive_regulation (promotes) of Localization (recruitment) of PKC associated with kinase c and morphine

5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 1.14

Other proteases known to activate PAR1 and PAR4 were also effective in causing translocation of PKC?

Positive_regulation (causing) of Localization (translocation) of PKC

6) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.05 Pain Relevance 0.22

PAR2-AP was ineffective in causing translocation of PKC?

Positive_regulation (causing) of Localization (translocation) of PKC

7) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.11

, which can be observed as a translocation of PKC?

Positive_regulation (observed) of Localization (translocation) of PKC

8) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.52 Pain Relevance 0.20

PAR1/4 agonists cause translocation of PKC-?

Positive_regulation (cause) of Localization (translocation) of PKC associated with agonist

9) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.08 Pain Relevance 0.27

We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?

Neg (not) Positive_regulation (not) of in amacrine cells Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts

10) Confidence 0.09 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.18 Pain Relevance 0.16

In this model, when AA is released in the presence of PKC activating-cofactors (DAG and Ca2+), AA facilitates activation of PKC and excitatory conditioning changes (reductions in K+ currents, enhanced light response, and spiking).

Positive_regulation (activation) of Localization (released) of PKC associated with kinase c

11) Confidence 0.08 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0.30

Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).

Positive_regulation (stimulated) of Localization (translocation) of PKC in fat cells associated with kinase c and obesity

12) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10

OFQ/N pretreatment resulted in translocation of PKC-alpha, G protein-coupled receptor kinase 2 (GRK2) and GRK3 from the cytosol to the membrane, and this translocation was also blocked by chelerythrine.

Positive_regulation (resulted) of Localization (translocation) of PKC-alpha

13) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130708 Disease Relevance 0 Pain Relevance 0.66

Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).

Positive_regulation (stimulated) of in muscle Localization (translocation) of PKC in fat cells associated with kinase c and obesity

14) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10

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