INT79557

Context Info Confidence 0.73 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 9 Disease Relevance 2.00 Pain Relevance 1.13

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)

Anatomy Link Frequency urine 4 plasma 2 kidney 1 Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 15 98.20 COX-2 inhibitor 5 92.32 cINOD 8 80.64 antagonist 20 5.00 withdrawal 15 5.00 alcohol 10 5.00 depression 5 5.00 Calcium channel 5 5.00

Disease Link Frequency Relevance Heat Body Weight 15 98.56 Polyuria 8 93.60 Diabetes Insipidus 22 90.96 Chronic Renal Failure 65 84.40 Renal Disease 50 79.76 Renal Insufficiency 15 70.44 INFLAMMATION 6 54.04 Obesity 25 41.68 Disease 35 36.00 Hyperthyroidism 5 31.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Semiquantitative immunoblotting using whole-kidney homogenates revealed that COX-2 inhibition caused significant increases in the abundance of AQP2 and NKCC2.

Localization (abundance) of AQP2 in kidney

1) Confidence 0.73 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.72 Pain Relevance 0.39

The effect variables were urinary excretions of aquaporin2 (u-AQP2), cyclic-AMP (u-c-AMP), urine volume (UV), free water clearance (CH2O), urine osmolarity (u-Osm), and plasma arginine vasopressin (p-AVP).

Localization (excretions) of aquaporin2 in plasma

2) Confidence 0.51 Published 2010 Journal BMC Nephrol Section Abstract Doc Link PMC2965705 Disease Relevance 0.33 Pain Relevance 0

However, it has never been studied to what extent the function of the principal cells is affected in patients with varying degrees of reduced renal function, when evaluated by simultaneous measurements of urinary excretions of aquaporin2 (u-AQP2) and cyclic-AMP (u-c-AMP), and plasma concentration of vasopressin (p-AVP) during urine concentrating and diluting.

Localization (excretions) of AQP2 in urine

3) Confidence 0.51 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.28 Pain Relevance 0

However, it has never been studied to what extent the function of the principal cells is affected in patients with varying degrees of reduced renal function, when evaluated by simultaneous measurements of urinary excretions of aquaporin2 (u-AQP2) and cyclic-AMP (u-c-AMP), and plasma concentration of vasopressin (p-AVP) during urine concentrating and diluting.

Localization (excretions) of aquaporin2 in urine

4) Confidence 0.51 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.28 Pain Relevance 0

The effect variables were urinary excretions of aquaporin2 (u-AQP2), cyclic-AMP (u-c-AMP), urine volume (UV), free water clearance (CH2O), urine osmolarity (u-Osm), and plasma arginine vasopressin (p-AVP).

Localization (excretions) of AQP2 in plasma

5) Confidence 0.51 Published 2010 Journal BMC Nephrol Section Abstract Doc Link PMC2965705 Disease Relevance 0.33 Pain Relevance 0

Relationship between e-GFR and AVP, c-AMP and AQP2

Localization (Relationship) of AQP2

6) Confidence 0.24 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.06 Pain Relevance 0

The effects of intrinsic vasopressin on urinary aquaporin-2 excretion and urine osmolality during surgery under general anesthesia.

Localization (excretion) of aquaporin-2 in urine associated with anesthesia

7) Confidence 0.09 Published 1999 Journal Anesth. Analg. Section Title Doc Link 9895089 Disease Relevance 0 Pain Relevance 0.24

IMPLICATIONS: The excessive increase of intrinsic vasopressin exactly augmented urinary aquaporin-2 excretion, resulting in urine concentration; however, anesthesia seemed to modify this process possibly by interfering with the aquaporin-2 action.

Localization (excretion) of aquaporin-2 in urine associated with anesthesia

8) Confidence 0.08 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9895089 Disease Relevance 0 Pain Relevance 0.34

A radioimmunoassay has been established to measure urinary aquaporin-2 excretion (u-AQP2).

Localization (excretion) of aquaporin-2

9) Confidence 0.08 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9895089 Disease Relevance 0 Pain Relevance 0.16

General Comments

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