INT79558

Context Info Confidence 0.31 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.25 Pain Relevance 0.33

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)

Anatomy Link Frequency urine 1 Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 6 99.14 ischemia 11 50.00 butorphanol 1 12.24 analgesia 1 11.04 Inflammation 11 5.00 cytokine 2 5.00 Inflammatory response 1 5.00 Bioavailability 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 17 98.00 Injury 27 92.32 Body Weight 4 57.60 Cv Unclassified Under Development 8 5.68 INFLAMMATION 13 5.00 Necrosis 7 5.00 Acute Renal Failure 4 5.00 Reperfusion Injury 3 5.00 Renal Disease 3 5.00 Natriuresis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot for AQP 2

AQP 2 Binding (blot) of

1) Confidence 0.31 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994366 Disease Relevance 0.25 Pain Relevance 0

IMPLICATIONS: The excessive increase of intrinsic vasopressin exactly augmented urinary aquaporin-2 excretion, resulting in urine concentration; however, anesthesia seemed to modify this process possibly by interfering with the aquaporin-2 action.

aquaporin-2 Binding (interfering) of in urine associated with anesthesia

2) Confidence 0.04 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9895089 Disease Relevance 0 Pain Relevance 0.33

General Comments

This test has worked.