INT79599

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Context Info
Confidence 1.00
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.16
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
Anatomy Link Frequency
corpus 1
blood vessels 1
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 30 97.16 Very High Very High Very High
headache 12 94.52 High High
adenocard 1 93.68 High High
Potency 1 88.00 High High
antagonist 6 68.28 Quite High
Bioavailability 3 66.96 Quite High
nud 8 55.92 Quite High
Pain 2 49.08 Quite Low
Angina 3 39.28 Quite Low
tolerance 6 37.72 Quite Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 12 99.72 Very High Very High Very High
Pulmonary Hypertension 119 99.10 Very High Very High Very High
Coronary Heart Disease 5 97.92 Very High Very High Very High
Cv General 3 Under Development 19 97.16 Very High Very High Very High
Rhinitis 1 96.16 Very High Very High Very High
Anaemia 1 95.32 Very High Very High Very High
Headache 12 94.52 High High
Increased Venous Pressure Under Development 22 93.80 High High
Heart Rate Under Development 2 93.20 High High
Pressure And Volume Under Development 2 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sildenafil is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP).
Protein_catabolism (degradation) of PDE5
1) Confidence 1.00 Published 2000 Journal Am. J. Med. Section Abstract Doc Link 11137498 Disease Relevance 0.35 Pain Relevance 0
PDE5 degrades cGMP in smooth muscle cells so as to maintain the contracted state of blood vessels [67].
Protein_catabolism (degrades) of PDE5 in blood vessels
2) Confidence 0.96 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.10 Pain Relevance 0.05
Sildenafil is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP).
Protein_catabolism (degradation) of phosphodiesterase type 5
3) Confidence 0.87 Published 2000 Journal Am. J. Med. Section Abstract Doc Link 11137498 Disease Relevance 0.35 Pain Relevance 0
Sildenafil has no direct relaxant effect on human corpus cavernosum but enhances the relaxant effect of nitric oxide (NO) on the corpus cavernosum by inhibiting PDE5, which is responsible for degradation of cGMP in this tissue.
Protein_catabolism (degradation) of PDE5 in corpus
4) Confidence 0.66 Published 1998 Journal Clin Ther Section Abstract Doc Link 9916601 Disease Relevance 0.16 Pain Relevance 0.03
Sildenafil inhibits the degradation of cGMP by PDE 5 and prolongs the actions of cGMP.
Protein_catabolism (degradation) of PDE 5
5) Confidence 0.50 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.65 Pain Relevance 0.16
As nitrates are strictly contraindicated in patients on PDE5I, consideration must be given to the risk of administering a PDE5I with a prolonged half-life, which would tend to complicate standard therapy for angina symptoms. 45 This important contraindication is due to the synergistic effect of nitrates (an exogenous source of NO) coupled with decreased degradation of the NO downstream effector cGMP by PDE5I.
Protein_catabolism (degradation) of PDE5I associated with cva
6) Confidence 0.49 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939761 Disease Relevance 0.29 Pain Relevance 0.05
Phosphodiesterase 5 inhibitors PH is associated with upregulation of vascular PDE5, which rapidly degrades cGMP, leading to reduced levels of nitric oxide, a potent vasodilator.
Protein_catabolism (degrades) of PDE5 associated with pulmonary hypertension
7) Confidence 0.39 Published 2010 Journal Curr Treat Options Cardiovasc Med Section Body Doc Link PMC2844955 Disease Relevance 1.26 Pain Relevance 0.09

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