INT79618

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|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1999
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1999|1999]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1999
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1999|1999]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
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fontcolor=white,
 
fontcolor=white,
 
label="Htr1a",
 
label="Htr1a",
URL="Htr1a"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:24473"
 
];
 
];
 
node2
 
node2
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style=filled,
 
style=filled,
 
fillcolor=yellow,
 
fillcolor=yellow,
URL=Positive_regulation
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Positive_regulation"
 
];
 
];
 
node3
 
node3
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fontcolor=white,
 
fontcolor=white,
 
label="POMC",
 
label="POMC",
URL="POMC"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:5443"
 
];
 
];
 
subgraph cluster_0 {
 
subgraph cluster_0 {
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{| cellspacing=5 cellpadding=2
 
{| cellspacing=5 cellpadding=2
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[small molecule metabolic process]] ([[POMC]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:small molecule metabolic process|small molecule metabolic process]] ([[G:5443|POMC]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[cell-cell signaling]] ([[POMC]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:cell-cell signaling|cell-cell signaling]] ([[G:5443|POMC]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[cytoplasm]] ([[POMC]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:cytoplasm|cytoplasm]] ([[G:5443|POMC]])
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[signal transducer activity]] ([[Htr1a]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:signal transducer activity|signal transducer activity]] ([[G:24473|Htr1a]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular space]] ([[POMC]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular space|extracellular space]] ([[G:5443|POMC]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[generation of precursor metabolites and energy]] ([[POMC]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:generation of precursor metabolites and energy|generation of precursor metabolites and energy]] ([[G:5443|POMC]])
 
|-
 
|-
 
|}
 
|}
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{| cellspacing=1 cellpadding=5 align=center
 
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Term
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[fluoxetine]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:fluoxetine|fluoxetine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[agonist]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:agonist|agonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 78.16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 78.16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[withdrawal]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Withdrawal|Withdrawal]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 49.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 49.28
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''5-HT1A'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">stimulation</span>) of <span style="color:#800000">'''adrenocorticotropic hormone'''</span> associated with <span style="color:#FF0000">'''fluoxetine'''</span>
+
|  [[G:24473|<span style="color:#800000">'''5-HT1A'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">stimulation</span>) of [[G:5443|<span style="color:#800000">'''adrenocorticotropic hormone'''</span>]] associated with <span style="color:#FF0000">'''fluoxetine'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.17
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.17
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1999
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1999|1999]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J. Pharmacol. Exp. Ther.|J. Pharmacol. Exp. Ther.]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:J. Pharmacol. Exp. Ther.|J. Pharmacol. Exp. Ther.]]

Latest revision as of 13:22, 20 September 2012

Context Info
Confidence 0.17
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
signal transducer activity (Htr1a) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Htr1a (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 9 97.16 Very High Very High Very High
agonist 1 78.16 Quite High
Withdrawal 3 49.28 Quite Low

|}

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion.
5-HT1A Positive_regulation (stimulation) of adrenocorticotropic hormone associated with fluoxetine
1) Confidence 0.17 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918559 Disease Relevance 0 Pain Relevance 0.39

[edit] General Comments

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