INT79618
From wiki-pain
(Difference between revisions)
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported | ||
| − | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 1999 | + | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| [[Y:1999|1999]] |
|- | |- | ||
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported | ||
| − | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 1999 | + | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| [[Y:1999|1999]] |
|- | |- | ||
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated | ||
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fontcolor=white, | fontcolor=white, | ||
label="Htr1a", | label="Htr1a", | ||
| − | URL=" | + | URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:24473" |
]; | ]; | ||
node2 | node2 | ||
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style=filled, | style=filled, | ||
fillcolor=yellow, | fillcolor=yellow, | ||
| − | URL=Positive_regulation | + | URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Positive_regulation" |
]; | ]; | ||
node3 | node3 | ||
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fontcolor=white, | fontcolor=white, | ||
label="POMC", | label="POMC", | ||
| − | URL=" | + | URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:5443" |
]; | ]; | ||
subgraph cluster_0 { | subgraph cluster_0 { | ||
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{| cellspacing=5 cellpadding=2 | {| cellspacing=5 cellpadding=2 | ||
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| − | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[small molecule metabolic process]] ([[POMC]]) | + | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:small molecule metabolic process|small molecule metabolic process]] ([[G:5443|POMC]]) |
| − | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[cell-cell signaling]] ([[POMC]]) | + | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:cell-cell signaling|cell-cell signaling]] ([[G:5443|POMC]]) |
| − | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[cytoplasm]] ([[POMC]]) | + | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:cytoplasm|cytoplasm]] ([[G:5443|POMC]]) |
|- | |- | ||
| − | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[signal transducer activity]] ([[Htr1a]]) | + | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:signal transducer activity|signal transducer activity]] ([[G:24473|Htr1a]]) |
| − | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular space]] ([[POMC]]) | + | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular space|extracellular space]] ([[G:5443|POMC]]) |
| − | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[generation of precursor metabolites and energy]] ([[POMC]]) | + | | style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:generation of precursor metabolites and energy|generation of precursor metabolites and energy]] ([[G:5443|POMC]]) |
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{| cellspacing=1 cellpadding=5 align=center | {| cellspacing=1 cellpadding=5 align=center | ||
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| − | ! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain | + | ! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link |
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency | ! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency | ||
| − | ! style="color: black; background:#AAFCFB; white-space:wrap;"| | + | ! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance |
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat | ! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat | ||
|- | |- | ||
| − | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[fluoxetine]] | + | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:fluoxetine|fluoxetine]] |
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9 | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9 | ||
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.16 | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.16 | ||
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} | ||
|- | |- | ||
| − | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[agonist]] | + | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:agonist|agonist]] |
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1 | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1 | ||
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 78.16 | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 78.16 | ||
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}} | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}} | ||
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| − | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[withdrawal]] | + | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:withdrawal|withdrawal]] |
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3 | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3 | ||
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 49.28 | | style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 49.28 | ||
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{| cellpadding=4 cellspacing=2 | {| cellpadding=4 cellspacing=2 | ||
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| − | | <span style="color:#800000">'''5-HT1A'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">stimulation</span>) of <span style="color:#800000">'''adrenocorticotropic hormone'''</span> associated with <span style="color:#FF0000">'''fluoxetine'''</span> | + | | [[G:24473|<span style="color:#800000">'''5-HT1A'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">stimulation</span>) of [[G:5443|<span style="color:#800000">'''adrenocorticotropic hormone'''</span>]] associated with <span style="color:#FF0000">'''fluoxetine'''</span> |
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|} | |} | ||
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 0.17 | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 0.17 | ||
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Published | ! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Published | ||
| − | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 1999 | + | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| [[Y:1999|1999]] |
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Journal | ! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Journal | ||
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| [[J:J. Pharmacol. Exp. Ther.|J. Pharmacol. Exp. Ther.]] | | style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| [[J:J. Pharmacol. Exp. Ther.|J. Pharmacol. Exp. Ther.]] | ||
Revision as of 09:19, 20 September 2012
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Sentences Mentioned In
| Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
| Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion. | |||||||||||||||
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General Comments
This test has worked.
