INT79618

Context Info Confidence 0.17 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.39

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC) signal transducer activity (Htr1a) extracellular space (POMC) generation of precursor metabolites and energy (POMC)

Htr1a (Rattus norvegicus) POMC (Homo sapiens)

Pain Link Frequency Relevance Heat fluoxetine 9 97.16 agonist 1 78.16 withdrawal 3 49.28

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion.

5-HT1A Positive_regulation (stimulation) of adrenocorticotropic hormone associated with fluoxetine

1) Confidence 0.17 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918559 Disease Relevance 0 Pain Relevance 0.39

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