INT79690

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 10.48
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
LS174T 2
brains 2
lung 2
microglial cells 2
PPARG (Homo sapiens)
PPARG - A12P (1)
Pain Link Frequency Relevance Heat
COX2 159 100.00 Very High Very High Very High
Dopamine 2 99.20 Very High Very High Very High
cINOD 22 99.00 Very High Very High Very High
Inflammatory mediators 1 96.08 Very High Very High Very High
aspirin 8 91.76 High High
Inflammation 26 86.32 High High
agonist 38 39.76 Quite Low
cOX1 5 25.00 Low Low
antagonist 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 283 99.84 Very High Very High Very High
Disease 49 99.40 Very High Very High Very High
Coronary Artery Disease 50 99.32 Very High Very High Very High
Drug Induced Neurotoxicity 8 99.32 Very High Very High Very High
Cancer 253 99.18 Very High Very High Very High
Malignant Neoplastic Disease 12 98.32 Very High Very High Very High
INFLAMMATION 44 98.28 Very High Very High Very High
Obesity 64 96.12 Very High Very High Very High
Metastasis 51 96.00 Very High Very High Very High
Skin Cancer 118 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate that a reduced PPARG expression due to specific promoter methylation is associated with advanced tumour stages (Duke's stages C–D), deep invasion, and, ultimately, shorter survival.
Negative_regulation (reduced) of Gene_expression (expression) of PPARG associated with cancer
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.97 Pain Relevance 0
All together these data demonstrate that extensive promoter methylation is associated with reduced PPARG expression in CRC cell lines.


Negative_regulation (reduced) of Gene_expression (expression) of PPARG associated with colon cancer
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.25 Pain Relevance 0
Thus, to determine whether PPARG reduced expression is correlated with DNA methylation, we examined the entire promoter region.
Spec (whether) Negative_regulation (reduced) of Spec (whether) Gene_expression (expression) of PPARG
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.64 Pain Relevance 0
The Kirsten ras ( K-ras ) oncogene regulates the expression of several genes, including suppressing the expression of peroxisomal proliferator-activated receptor gamma (PPARgamma).
Negative_regulation (suppressing) of Gene_expression (expression) of PPARgamma
4) Confidence 0.56 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.74 Pain Relevance 0.18
We have already reported that reduced PPARG expression in sporadic CRCs is not associated with LOH [6].
Negative_regulation (reduced) of Gene_expression (expression) of PPARG associated with colon cancer
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.66 Pain Relevance 0
80) and correlated with reduction/loss of PPARG expression (Figure 1, panel E and Table 1).
Negative_regulation (loss) of Gene_expression (expression) of PPARG
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.48 Pain Relevance 0
Reduction of PPARG gene expression in the PPARG?
Negative_regulation (Reduction) of Gene_expression (expression) of PPARG gene
7) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.48 Pain Relevance 0
The Kirsten ras ( K-ras ) oncogene regulates the expression of several genes, including suppressing the expression of peroxisomal proliferator-activated receptor gamma (PPARgamma).
Negative_regulation (suppressing) of Gene_expression (expression) of peroxisomal proliferator-activated receptor gamma
8) Confidence 0.41 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.75 Pain Relevance 0.13
In other organs, however, for example, in primary cancers of the lung versus normal lung tissues, decreased expression levels of PPARG were found and associated with poor prognosis [16].
Negative_regulation (decreased) of Gene_expression (expression) of PPARG in lung associated with cancer
9) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 2.22 Pain Relevance 0.11
The constructed multitumor TMA-1 consisted of 3448 primary tumors from 132 different tumor subtypes and 26 different normal tissues and allowed us to determine the prevalence of COX2 and PPARG expression in nontumorous tissues and corresponding malignant tumors.
Spec (determine) Negative_regulation (prevalence) of Gene_expression (expression) of PPARG associated with malignant neoplastic disease, cancer and cox2
10) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 0.55 Pain Relevance 0.05
Pooled estimate of CHD odds ratios were calculated from published studies for the PPARG Ala12Pro SNP including 6898 cases and 11?
Negative_regulation (published) of Gene_expression (studies) of PPARG (A12P) associated with coronary artery disease
11) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.79 Pain Relevance 0
We here show that treatment of LS174T cells with indomethacin reduced arachidonic acid uptake as well as reduced expressions of fatty acid translocase/CD36 and peroxisome proliferators-activated receptor gamma.
Negative_regulation (reduced) of Gene_expression (expressions) of peroxisome proliferators-activated receptor gamma in LS174T
12) Confidence 0.34 Published 2010 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19944063 Disease Relevance 0.42 Pain Relevance 0.28
Therefore, the present study suggests the involvement of reduction of PPAR gamma expression in METH-induced neurotoxicity.
Negative_regulation (reduction) of Gene_expression (expression) of PPAR gamma associated with drug induced neurotoxicity
13) Confidence 0.33 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 18946735 Disease Relevance 0.40 Pain Relevance 0.24
Thus, expression levels of COX-1, COX-2, and PPARgamma may change in AD brains.
Negative_regulation (levels) of Gene_expression (expression) of PPARgamma in brains associated with disease
14) Confidence 0.27 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9920782 Disease Relevance 0.73 Pain Relevance 0.33
The reduction of dopamine transporter (DAT)-positive signals and PPAR gamma expression, and accumulation of activated microglial cells were significantly and dose-dependently attenuated by four injections of a nonsteroidal anti-inflammatory drug and a PPAR gamma ligand, ibuprofen (10 or 20 mg/kg x 4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin.
Negative_regulation (attenuated) of Gene_expression (expression) of PPAR gamma in microglial cells associated with aspirin, dopamine, inflammation and cinod
15) Confidence 0.25 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 18946735 Disease Relevance 0.34 Pain Relevance 0.23

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