INT7970

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Context Info
Confidence 0.71
First Reported 1980
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 120
Total Number 123
Disease Relevance 44.42
Pain Relevance 15.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
follicle 11
plasma 8
pituitary 8
ovaries 3
gonadal 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 591 100.00 Very High Very High Very High
withdrawal 192 100.00 Very High Very High Very High
Dopamine 19 100.00 Very High Very High Very High
narcan 65 99.98 Very High Very High Very High
Buprenorphine 6 99.76 Very High Very High Very High
tolerance 33 99.42 Very High Very High Very High
Enkephalin 5 99.40 Very High Very High Very High
Morphine 10 99.36 Very High Very High Very High
ketamine 2 99.36 Very High Very High Very High
antagonist 488 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 1058 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 76 100.00 Very High Very High Very High
Cancer 506 99.88 Very High Very High Very High
Hypoglycemia 8 99.78 Very High Very High Very High
Reprotox - General 2 262 99.76 Very High Very High Very High
Hypogonadotropic Hypogonadism 371 99.64 Very High Very High Very High
Hemorrhage 25 99.64 Very High Very High Very High
Breast Cancer 75 99.04 Very High Very High Very High
Stress 106 99.00 Very High Very High Very High
Opiate Addiction 9 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH.
Gene_expression (production) of LH in pituitary
1) Confidence 0.71 Published 2003 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 12963096 Disease Relevance 0.08 Pain Relevance 0.15
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Gene_expression (synthesis) of LH in follicle
2) Confidence 0.70 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.21
Morphine significantly decreased plasma LH levels in all groups examined (P less than 0.01).
Gene_expression (levels) of LH in plasma associated with morphine
3) Confidence 0.68 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.21 Pain Relevance 0.85
LH levels after chronic heroin use were lower than control levels but the degree of LH suppression was approximately the same as after the acute doses of heroin.
Gene_expression (suppression) of LH associated with opiate addiction
4) Confidence 0.67 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.28 Pain Relevance 0.38
Presence of a zero time lag between LH and P at symptom onset in women with PMS may indicate an aberrance in corpus luteum response to LH stimulation.


Gene_expression (Presence) of LH in corpus luteum
5) Confidence 0.66 Published 1995 Journal Fertil. Steril. Section Body Doc Link 7615105 Disease Relevance 0.06 Pain Relevance 0
The observation that hypoglycemia inhibited LH levels only during a period of restraint suggests either an additive or synergistic effect of these two stresses on LH secretion.
Gene_expression (levels) of LH associated with stress and hypoglycemia
6) Confidence 0.63 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.58 Pain Relevance 0.37
Tolerance to buprenorphine effects on LH and prolactin levels did not occur during chronic drug administration.
Gene_expression (levels) of LH associated with tolerance and buprenorphine
7) Confidence 0.62 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 1.09
After 22 days of chronic naltrexone maintenance, T levels were in the high normal range and LH levels were in the low normal range.
Gene_expression (levels) of LH
8) Confidence 0.60 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.25 Pain Relevance 0.41
After TP, however, despite unchanged basal LH levels (mean +/- S.E.M.: 27.0 +/- 3.4 vs 21.2 +/- 3.21 microU/ml), LH significantly increased in response to NAL.
Gene_expression (levels) of LH associated with narcan
9) Confidence 0.60 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3933025 Disease Relevance 0.16 Pain Relevance 0.50
In fertile women, naloxone administration increases LH levels in the luteal phase but not in the follicular phase.
Gene_expression (levels) of LH associated with narcan
10) Confidence 0.54 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.29
During the first week, both follicle-stimulating hormone (FSH) and LH were undetectable.
Gene_expression (undetectable) of LH in follicle
11) Confidence 0.54 Published 1989 Journal Fertil. Steril. Section Abstract Doc Link 2494080 Disease Relevance 0 Pain Relevance 0.08
Others have reported that patients undergoing ART with low basal LH levels (< 3 IU/L) did not differ significantly from controls in terms of response to COH, but there was a clear trend toward poorer implantation and CP rates [14].
Gene_expression (levels) of LH
12) Confidence 0.53 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.10 Pain Relevance 0.03
Mukherjee et al. [13] suggested that an elevated day 3 FSH: LH ratio >3.6, in the presence of a normal day 3 FSH is predictive of a poor response to ovarian stimulation.
Gene_expression (predictive) of LH
13) Confidence 0.53 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.14 Pain Relevance 0.14
Since the distribution of LH levels was not parametric, comparison of LH levels in between the groups of the different outcome measures (CP, miscarriage and LB) was done using a Mann-Whitney U test.
Gene_expression (levels) of LH associated with reprotox - general 1
14) Confidence 0.53 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.19 Pain Relevance 0
The expression of LH/hGC-R varied during the women's cycle phase, with the maximal expression occurring during the luteal phase, and a main localization in the luminal and glandular epithelial cells of endometrium [27].
Gene_expression (expression) of LH in endometrium
15) Confidence 0.53 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0 Pain Relevance 0
More recently, we confirmed not only that specific LH/hCG-Rs can be detected in human EC, but also that their expression is apparently related to the cancer grading [39].
Gene_expression (detected) of LH associated with endometriosis (extended) and cancer
16) Confidence 0.53 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 1.13 Pain Relevance 0.12
In group III, the single high dose of 1200 mg VPA significantly suppressed serum LH levels.
Gene_expression (levels) of LH
17) Confidence 0.51 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.27
At the initial visit, history and physical examination, with screening tests, including serum hormone levels (estradiol (E2), FSH, LH,), routine chemistries, lipid profiles (total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglyceride (TG)), gynecologic sonography, mammography, EKG, and Pap smear were obtained.
Gene_expression (levels) of LH associated with disorder of lipid metabolism
18) Confidence 0.49 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628120 Disease Relevance 1.02 Pain Relevance 0.03
Plasma levels of estrogen, progesterone, luteinizing hormone (LH), testosterone, and beta-endorphin were determined at each experimental session.
Spec (determined) Gene_expression (levels) of LH in Plasma
19) Confidence 0.48 Published 1997 Journal Psychosom Med Section Abstract Doc Link 9316184 Disease Relevance 0.24 Pain Relevance 0.24
Neither the basal serum LH nor the FSH: LH ratio was a variable to guide the COH.
Gene_expression (guide) of serum LH
20) Confidence 0.46 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.67 Pain Relevance 0.03

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