INT79709

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Context Info
Confidence 0.24
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 4.80
Pain Relevance 4.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
grid 1
lateral 1
anterior 1
nerve 1
brain 1
M1 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 18 99.84 Very High Very High Very High
halothane 18 99.54 Very High Very High Very High
imagery 16 98.88 Very High Very High Very High
Antinociceptive 2 98.48 Very High Very High Very High
Quantitative sensory testing 1 97.48 Very High Very High Very High
Pain 11 93.56 High High
Leflunomide 10 91.76 High High
chronic pain syndrome 4 90.76 High High
analgesia 2 88.32 High High
rheumatoid arthritis 4 83.04 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 94 98.24 Very High Very High Very High
Nociception 2 97.32 Very High Very High Very High
Shock 1 96.76 Very High Very High Very High
Cognitive Disorder 6 94.48 High High
Demyelinating Disease 26 94.00 High High
Systemic Lupus Erythematosus 15 93.64 High High
Pain 14 93.56 High High
Complex Regional Pain Syndromes 4 90.76 High High
Depression 20 89.16 High High
Rheumatoid Arthritis 4 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alkylthio-TZTPs (3-(3-alkylthio-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-met hylpyridines) and corresponding azabicyclic analogs were tested for m1 efficacy in cloned human m1 receptors and for antinociceptive activity in the mouse grid shock assay.
Regulation (efficacy) of m1 in grid associated with shock and antinociceptive
1) Confidence 0.24 Published 1995 Journal Life Sci. Section Abstract Doc Link 10188779 Disease Relevance 0.10 Pain Relevance 0.37
The pharmacokinetics of M1 are not affected by food intake, and dosage requirements are not influenced by age or gender.
Neg (not) Regulation (affected) of M1
2) Confidence 0.19 Published 2002 Journal Clin Pharmacokinet Section Abstract Doc Link 12074690 Disease Relevance 0.28 Pain Relevance 0.52
Therefore, we have investigated the effects of these compounds on isolated m1 and m3 muscarinic receptor function.
Spec (investigated) Regulation (effects) of m1
3) Confidence 0.08 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0.17 Pain Relevance 0.25
In the second series of experiments, we measured the effects of M1 or DLPFC rTMS on the threshold and recruitment curves of the RIII nociceptive reflex evoked by ipsilateral electrical stimulation of the sural nerve and recorded on the biceps femoris of both lower limbs.
Regulation (effects) of M1 in nerve associated with nociception
4) Confidence 0.05 Published 2009 Journal Pain Section Abstract Doc Link 19822394 Disease Relevance 0.40 Pain Relevance 0.67
Halothane, similar to its known effect on m1 signalling, dose-dependently depressed m3 function.
Regulation (effect) of m1 associated with halothane
5) Confidence 0.05 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0 Pain Relevance 0.17
To summarize, weaker binding was observed to full length AQP4, which is also evident from the lower titer values of M-1 AQP4-IgG (Table 1).


Spec (evident) Regulation (values) of M-1 in M-1
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.91 Pain Relevance 0.19
To determine the site of action of the volatile anaesthetics we compared anaesthetic effects on m1, m3 and AT1A receptor function and studied the effects of volatile anaesthetics on signalling induced by intracellular injection of the second messenger IP3.
Regulation (effects) of m1
7) Confidence 0.04 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0.13 Pain Relevance 0.29
Volatile anaesthetics have differential effects on recombinant m1 and m3 muscarinic acetylcholine receptor function.
Regulation (effects) of m1
8) Confidence 0.04 Published 1998 Journal Br J Anaesth Section Title Doc Link 9924234 Disease Relevance 0.19 Pain Relevance 0.25
Isoflurane had no effect on m1 signalling, but profoundly inhibited m3 signalling.
Neg (no) Regulation (effect) of m1 associated with isoflurane
9) Confidence 0.03 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0 Pain Relevance 0.23
Desflurane had a biphasic effect on m1 signalling, enhancing at a concentration of 0.46 mmol litre-1 but depressing at 0.92 mmol litre-1.
Regulation (effect) of m1
10) Confidence 0.03 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0.11 Pain Relevance 0.29
A statistical analysis of the MRI coordinates (x, y, z) of the targets revealed that the M1 target was more posterior, the dlPMC target more superficial and the dlPFC target more anterior, lateral, and deeper, using neuronavigation compared to the "standard" procedure.
Regulation (target) of M1 in lateral associated with imagery
11) Confidence 0.02 Published 2010 Journal Neurophysiol Clin Section Abstract Doc Link 20230933 Disease Relevance 0.29 Pain Relevance 0.38
In the other patients, the "standard" procedure located the dlPMC target on the M1/dlPMC border and the dlPFC target on the dlPMC/dlPFC border.
Regulation (target) of M1
12) Confidence 0.02 Published 2010 Journal Neurophysiol Clin Section Abstract Doc Link 20230933 Disease Relevance 0.44 Pain Relevance 0.43
The aim of our study was to compare the locations of M1, dlPMC and dlPFC targets provided by the "standard" procedure of coil positioning and those provided by using a neuronavigation system integrating individual brain magnetic resonance imaging (MRI).
Regulation (targets) of M1 in brain associated with imagery
13) Confidence 0.02 Published 2010 Journal Neurophysiol Clin Section Abstract Doc Link 20230933 Disease Relevance 0.47 Pain Relevance 0.49
A statistical analysis of the MRI coordinates (x, y, z) of the targets revealed that the M1 target was more posterior, the dlPMC target more superficial and the dlPFC target more anterior, lateral, and deeper, using neuronavigation compared to the "standard" procedure.
Regulation (target) of M1 in anterior associated with imagery
14) Confidence 0.01 Published 2010 Journal Neurophysiol Clin Section Abstract Doc Link 20230933 Disease Relevance 0.29 Pain Relevance 0.38

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