INT79778

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Context Info
Confidence 0.08
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 4.21
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, TNF) plasma membrane (Tlr4, TNF) intracellular (Tlr4, TNF)
extracellular space (TNF) extracellular region (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
lung 4
neutrophil 4
hemocyte 2
Tlr4 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 133 100.00 Very High Very High Very High
Inflammation 178 96.28 Very High Very High Very High
Inflammatory response 54 95.20 Very High Very High Very High
hyperexcitability 1 91.84 High High
chemokine 34 53.20 Quite High
nociceptor 1 25.00 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Sepsis 104 98.84 Very High Very High Very High
INFLAMMATION 104 96.28 Very High Very High Very High
Pneumonia 138 95.52 Very High Very High Very High
Targeted Disruption 12 86.76 High High
Injury 8 82.20 Quite High
Nociception 2 75.00 Quite High
Endotoxemia 26 69.00 Quite High
Nervous System Injury 1 43.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strikingly, neutrophil influx and TNF release induced by high dose S-LPS or R-LPS was diminished in the presence of CD14.
LPS Positive_regulation (induced) of Localization (release) of TNF in neutrophil
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2855719 Disease Relevance 0.65 Pain Relevance 0.25
In the present study, we found at low doses that R-LPS (but not S-LPS) induced TNF secretion in the lung in a CD14-independent manner, whereas PMN recruitment into the lung was induced by these LPS chemotypes in a CD14-dependent manner.
LPS Positive_regulation (induced) of Localization (secretion) of TNF in lung
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.27 Pain Relevance 0.21
Strikingly, neutrophil influx and TNF release induced by high dose S-LPS or R-LPS was diminished in the presence of CD14.
LPS Positive_regulation (induced) of Localization (release) of TNF in neutrophil
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2855719 Disease Relevance 0.65 Pain Relevance 0.25
Moreover, CD14 does not facilitate local release of TNF induced by intrapulmonary R-LPS at any dose tested.


LPS Neg (not) Positive_regulation (induced) of Localization (release) of TNF
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.39 Pain Relevance 0.20
R-LPS tended to elicit increased influx of PMNs in BALF of CD14KO mice (not significant, Fig. 3A), but did induce increased release of TNF (P<0.01, Fig. 3D).
LPS Positive_regulation (induce) of Localization (release) of TNF
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.31 Pain Relevance 0.21
In the present study, we found at low doses that R-LPS (but not S-LPS) induced TNF secretion in the lung in a CD14-independent manner, whereas PMN recruitment into the lung was induced by these LPS chemotypes in a CD14-dependent manner.
LPS Positive_regulation (induced) of Localization (secretion) of TNF in lung
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.27 Pain Relevance 0.21
At concentrations that completely abrogated LPS-induced HMGB1 release, EGCG did not affect LPS-induced nitric oxide release, but only partially attenuated LPS-induced TNF secretion.
LPS Positive_regulation (induced) of Localization (secretion) of TNF
7) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0 Pain Relevance 0
Because EGCG could inhibit LPS-induced TNF release in vitro, we strategically administered EGCG in a delayed fashion (at 24 h post CLP) to preserve a potentially beneficial early TNF response.
LPS Positive_regulation (induced) of Localization (release) of TNF
8) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 1.20 Pain Relevance 0.14
We speculate that the addition of LPS to the incubation medium containing hemocytes enhanced the release of hemocyte-derived cytokine-like factors such as interleukin-1 and tumor necrosis factor.
LPS Positive_regulation (enhanced) of Localization (release) of tumor necrosis factor in hemocyte associated with necrosis, cancer and cytokine
9) Confidence 0.01 Published 1999 Journal J. Exp. Biol. Section Abstract Doc Link 9929463 Disease Relevance 0.47 Pain Relevance 0.15

General Comments

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