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Context Info
Confidence 0.04
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

El2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 2 98.44 Very High Very High Very High
orphanin 6 98.14 Very High Very High Very High
Opioid 1 89.92 High High
Kappa opioid receptor 2 80.64 Quite High
agonist 2 66.24 Quite High
opioid receptor 1 53.28 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nociceptin conformation provides for the selective preference of the ORL1 receptor for nociceptin over dynorphin A, conferred by residue positions 5 and 6 (TG versus LR), and the favourable interaction of its highly positively charged core (residues 8-13) with the EL2 loop, thought to mediate receptor activation.
EL2 Binding (interaction) of associated with dynorphin and orphanin
1) Confidence 0.04 Published 1998 Journal Protein Eng. Section Abstract Doc Link 9930666 Disease Relevance 0 Pain Relevance 0.58

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