INT7996

Context Info Confidence 0.64 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 18 Total Number 19 Disease Relevance 6.47 Pain Relevance 5.51

isomerase activity (Ptgds) transport (Ptgds) nuclear envelope (Ptgds) extracellular space (Ptgds) extracellular region (Ptgds) Golgi apparatus (Ptgds)

Anatomy Link Frequency spinal cord 4 dorsal root ganglia 3 spinal 2 brain 1 lumen 1 Ptgds (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 136 99.84 COX2 22 99.76 Inflammation 129 99.60 Paracetamol 2 97.20 Potency 1 96.56 Pain 40 96.28 dexamethasone 8 95.06 Hippocampus 3 94.24 antagonist 13 90.92 noradrenaline 7 89.72

Disease Link Frequency Relevance Heat INFLAMMATION 150 99.60 Multiple Sclerosis 264 99.16 Injury 5 96.96 Pain 59 96.28 Stress 155 95.80 Nociception 6 95.36 Pressure And Volume Under Development 2 93.48 Peptic Ulcer 3 92.88 Frailty 3 86.16 Nervous System Injury 2 84.80

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In contrast, basal expression of lipocalin prostaglandin D synthase messenger RNA in spinal cord and dorsal root ganglia was not significantly altered by endotoxin.

Gene_expression (expression) of lipocalin prostaglandin D synthase in spinal cord associated with spinal cord

1) Confidence 0.64 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.06 Pain Relevance 0.32

Dexamethasone (1 mg/kg s.c. at -18 h and -1 h) attenuated the effect endotoxin on the expression of interleukin-1beta, cyclooxygenase-2, and membrane bound prostaglandin E synthase messenger RNA in all tissues investigated, but did not significantly influence expression of lipocalin prostaglandin D synthase mRNA in spinal cord and dorsal root ganglia.

Gene_expression (expression) of lipocalin prostaglandin D synthase mRNA in dorsal root ganglia associated with dexamethasone and spinal cord

2) Confidence 0.64 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0 Pain Relevance 0.29

PGD2 produced a dose-related inflammation-augmenting effect, whereas hydrocortisone and the PG synthesis inhibitors, paracetamol and mefenamic acid, induced attenuation of the peripheral oedema.

Gene_expression (produced) of PGD2 associated with pressure and volume under development, paracetamol and inflammation

3) Confidence 0.56 Published 1989 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2571705 Disease Relevance 0.46 Pain Relevance 0.41

Prostaglandin (PG) D2 represented approximately 10% of the PGs produced in the lumen, irrespective of the presence or absence of luminal PGDS, suggesting that this protein is not involved in PGD2 biosynthesis.

Gene_expression (biosynthesis) of PGD2 in lumen

4) Confidence 0.52 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 11804963 Disease Relevance 0.08 Pain Relevance 0.09

Since there is little known about the regulation of prostaglandin synthases, the present study was conducted in order to determine the effect of endotoxin treatment on the expression of messenger RNA encoding interleukin 1beta, cyclooxygenase-2, and prostaglandin synthases mediating the formation of prostaglandin E(2) (membrane bound prostaglandin E synthase) and prostaglandin D(2) (lipocalin prostaglandin D synthase) in spinal cord, dorsal root ganglia and skin of rats.

Gene_expression (expression) of lipocalin prostaglandin D synthase in skin associated with spinal cord

5) Confidence 0.49 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.08 Pain Relevance 0.28

Prostaglandin D2(PGD2) is the most produced prostanoid in the CNS of mammals, and in behavioral experiments it has been implicated in the modulation of spinal nociception.

Gene_expression (produced) of Prostaglandin D2 in spinal associated with nociception

6) Confidence 0.47 Published 2008 Journal Neuroscience Section Abstract Doc Link 18678231 Disease Relevance 0.32 Pain Relevance 0.21

Prostaglandin D2(PGD2) is the most produced prostanoid in the CNS of mammals, and in behavioral experiments it has been implicated in the modulation of spinal nociception.

Gene_expression (produced) of PGD2 in spinal associated with nociception

7) Confidence 0.47 Published 2008 Journal Neuroscience Section Abstract Doc Link 18678231 Disease Relevance 0.32 Pain Relevance 0.21

COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue.

Gene_expression (synthesis) of PGD2 associated with cox2

8) Confidence 0.27 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 14698037 Disease Relevance 0 Pain Relevance 0.05

In contrast, basal expression of lipocalin prostaglandin D synthase messenger RNA in spinal cord and dorsal root ganglia was not significantly altered by endotoxin.

Gene_expression (expression) of lipocalin prostaglandin D synthase in dorsal root ganglia associated with spinal cord

9) Confidence 0.22 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.06 Pain Relevance 0.32

Dexamethasone (1 mg/kg s.c. at -18 h and -1 h) attenuated the effect endotoxin on the expression of interleukin-1beta, cyclooxygenase-2, and membrane bound prostaglandin E synthase messenger RNA in all tissues investigated, but did not significantly influence expression of lipocalin prostaglandin D synthase mRNA in spinal cord and dorsal root ganglia.

Gene_expression (expression) of lipocalin prostaglandin D synthase mRNA in spinal cord associated with dexamethasone and spinal cord

10) Confidence 0.22 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0 Pain Relevance 0.29

These higher levels of anti-inflammatory prostaglandin correlated with higher expression of its specific enzymatic source, lipocalin prostaglandin D synthase (PGDS) in the S and EAE+S groups (western blot analysis in figure 4C with densitometric analysis of the band, F: 19,88, dF: 7).

Gene_expression (expression) of prostaglandin D synthase in band associated with multiple sclerosis and inflammation

11) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.81 Pain Relevance 0.43

We quantitated mRNA levels for enzymes involved in the prostaglandin biosynthetic pathways and found that both COX-2 and PGE synthase (PGEs) mRNA levels were increased in the brain; no changes were found for expression of COX-1 or PGD synthase mRNA.

Gene_expression (expression) of PGD synthase mRNA in brain

12) Confidence 0.21 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.34 Pain Relevance 0.48

In the control rats, 4 kinds of PGs, i.e., 6-keto-PGF1 alpha, PGF2 alpha, PGE2 and PGD2, were detected in gastric mucosa, but no LT was detected.

Gene_expression (detected) of PGD2

13) Confidence 0.20 Published 1992 Journal Arzneimittelforschung Section Abstract Doc Link 1359896 Disease Relevance 0.33 Pain Relevance 0

Likewise, PGH2, a common precursor of PGs, appears to be selectively consumed by the PGE2 pathway rather than the PGI2 and PGD2 pathways, thereby producing PGE2 in the spinal cords of EAE mice [43].

Gene_expression (pathway) of PGD2 in spinal cords associated with multiple sclerosis

14) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 0.65 Pain Relevance 0.07

Since there is little known about the regulation of prostaglandin synthases, the present study was conducted in order to determine the effect of endotoxin treatment on the expression of messenger RNA encoding interleukin 1beta, cyclooxygenase-2, and prostaglandin synthases mediating the formation of prostaglandin E(2) (membrane bound prostaglandin E synthase) and prostaglandin D(2) (lipocalin prostaglandin D synthase) in spinal cord, dorsal root ganglia and skin of rats.

Gene_expression (expression) of lipocalin prostaglandin D synthase in spinal cord associated with spinal cord

15) Confidence 0.17 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.08 Pain Relevance 0.28

Since there is little known about the regulation of prostaglandin synthases, the present study was conducted in order to determine the effect of endotoxin treatment on the expression of messenger RNA encoding interleukin 1beta, cyclooxygenase-2, and prostaglandin synthases mediating the formation of prostaglandin E(2) (membrane bound prostaglandin E synthase) and prostaglandin D(2) (lipocalin prostaglandin D synthase) in spinal cord, dorsal root ganglia and skin of rats.

Gene_expression (expression) of lipocalin prostaglandin D synthase in dorsal root ganglia associated with spinal cord

16) Confidence 0.17 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.08 Pain Relevance 0.28

We observed significant changes in expression of several key enzymes (3-alpha-hydroxysteroid dehydrogenase, phospholipase a2, prostaglandin d2 synthase, and COX2) involved in eicosanoid biosynthesis (Table 4, Arachidonic acid cascade and mediators of inflammation).

Gene_expression (expression) of d2 synthase associated with inflammation and cox2

17) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.51 Pain Relevance 0.72

Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.

Gene_expression (ineffective) of PGD2

18) Confidence 0.09 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.78

In the COX pathway, enzymes convert PGH2 to the major physiologically active products, PGD2, PGE2, PGF2?

Gene_expression (products) of PGD2

19) Confidence 0.05 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514706 Disease Relevance 0.26 Pain Relevance 0

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