INT7997

From wiki-pain
Revision as of 17:51, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 51
Total Number 54
Disease Relevance 34.28
Pain Relevance 13.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
eosinophils 6
neutrophil 3
Platelet 2
blood 2
paw 2
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 41 100.00 Very High Very High Very High
Migraine 17 99.88 Very High Very High Very High
Thermal hyperalgesia 40 99.84 Very High Very High Very High
Pain 43 99.80 Very High Very High Very High
cINOD 141 99.68 Very High Very High Very High
aspirin 776 99.20 Very High Very High Very High
withdrawal 4 98.46 Very High Very High Very High
Cluster headache 3 97.88 Very High Very High Very High
Inflammation 97 97.50 Very High Very High Very High
anesthesia 16 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine With Aura 4 99.88 Very High Very High Very High
Hyperalgesia 48 99.84 Very High Very High Very High
Polyps 17 99.84 Very High Very High Very High
Asthma 1281 99.80 Very High Very High Very High
Pain 43 99.80 Very High Very High Very High
Occupational Lung Diseases 12 99.54 Very High Very High Very High
Shock 1 99.54 Very High Very High Very High
Ulcers 29 99.36 Very High Very High Very High
INFLAMMATION 132 99.06 Very High Very High Very High
Myocardial Infarction 28 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTB4 and LTC4 production from the gastric mucosa in the soybean and corn groups were significantly higher than those in the control group, and the LTC4 production in the perilla group was significantly lower than that in the corn group.
Gene_expression (production) of LTC4
1) Confidence 0.76 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12878448 Disease Relevance 0.05 Pain Relevance 0.08
LTC4 synthase is overexpressed in bronchi and its mRNA is upregulated in peripheral blood eosinophils.
Gene_expression (overexpressed) of LTC4 in eosinophils
2) Confidence 0.67 Published 2002 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 14561202 Disease Relevance 1.25 Pain Relevance 0.35
The finding in that syndrome of hyperreactive basophils suggests that the NSAID hypersensitivity syndrome is due to the associated effect of several factors: 1) Localized inflammatory processes causing a non specific cellular hyperreactivity; 2) An abnormal pharmacogenetic reaction to NSAIDs resulting in a hyperproduction of LTC4 and other mediators by activated mast cells, basophils and eosinophils.
Gene_expression (hyperproduction) of LTC4 in basophils associated with inflammation, syndrome, hypersensitivity and cinod
3) Confidence 0.66 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17017929 Disease Relevance 0.81 Pain Relevance 0.52
LTA4h and LTC4s mRNAs were expressed in both spinal neurons and microglia.
Gene_expression (expressed) of LTC4s in microglia
4) Confidence 0.60 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.04 Pain Relevance 0.66
Leukotriene C4 synthase (LTC4S) is the terminal enzyme in cysLT production and is a strong candidate gene in the pathogenesis of aspirin-intolerant asthma (AIA).
Gene_expression (production) of LTC4S associated with asthma and aspirin
5) Confidence 0.54 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340173 Disease Relevance 1.04 Pain Relevance 0.40
LTB4 and LTC4 production from the gastric mucosa in the soybean and corn groups were significantly higher than those in the control group, and the LTC4 production in the perilla group was significantly lower than that in the corn group.
Gene_expression (production) of LTC4
6) Confidence 0.52 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12878448 Disease Relevance 0 Pain Relevance 0
In contrast, LTC4 and LTD4 (peptide-LTs) were detected and the sum of their levels was 18.5 +/- 7.1 ng/g tissue.
Gene_expression (detected) of LTC4
7) Confidence 0.47 Published 1992 Journal Arzneimittelforschung Section Abstract Doc Link 1359896 Disease Relevance 0.37 Pain Relevance 0.05
Higher LTB4 and LTC4 levels in the cerebrospinal fluid of patients with SSPE indicate that these compounds participate in chronic inflammatory reaction around cerebral veins.
Gene_expression (levels) of LTC4 in cerebral veins associated with inflammation and subacute sclerosing panencephalitis
8) Confidence 0.46 Published 1994 Journal Pol Tyg Lek Section Abstract Doc Link 7651922 Disease Relevance 0.86 Pain Relevance 0.14
LTC4 synthase, the terminal enzyme for cys-LT production, is markedly overexpressed in eosinophils and mast cells from bronchial biopsy specimens of most patients with AIA.
Gene_expression (overexpressed) of LTC4 synthase in mast cells associated with asthma
9) Confidence 0.43 Published 1999 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 10400832 Disease Relevance 1.33 Pain Relevance 0.66
During the attack phase of classical migraine both LTC4 and LTB4 were present in the peripheral blood, while the post-attack phase was characterized by the disappearance of LTC4 and the presence of LTB4 and its transisomer delta 6-trans-LTB4.
Gene_expression (present) of LTC4 in blood associated with migraine with aura and migraine
10) Confidence 0.42 Published 1991 Journal Headache Section Abstract Doc Link 1889985 Disease Relevance 1.14 Pain Relevance 1.09
The key enzyme, LTC4 synthase, is overexpressed in bronchi and its mRNA is upregulated in peripheral blood eosinophils.
Gene_expression (overexpressed) of LTC4 in eosinophils
11) Confidence 0.39 Published 2001 Journal Curr Opin Allergy Clin Immunol Section Abstract Doc Link 11964666 Disease Relevance 1.00 Pain Relevance 0.42
These results are consistent with previous in vitro observations that [3H]LTC4 is transferred from CSF into blood by an efficient transport system for LTC4 in choroid plexus.
Gene_expression (transferred) of LTC4 in choroid plexus
12) Confidence 0.39 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3081687 Disease Relevance 0 Pain Relevance 0.10
LTB4 and LTC4 synthesis by cultured antral and duodenal mucosa obtained from duodenal ulcer patients was twofold higher than their synthesis by normal subjects.
Gene_expression (synthesis) of LTC4 associated with duodenal ulcer
13) Confidence 0.38 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.84 Pain Relevance 0.09
This study was undertaken to identify those events of bacteremic shock that pathophysiologic levels of leukotriene C4 (LTC4) alone were sufficient to cause.
Gene_expression (levels) of LTC4 associated with shock
14) Confidence 0.32 Published 1997 Journal Shock Section Abstract Doc Link 9110414 Disease Relevance 0.17 Pain Relevance 0.09
In 11 patients PAF, LTB4, and LTC4 generation was also assessed after 4 weeks of treatment resulting in ulcer healing and found to be significantly reduced when compared with their synthesis when the ulcer was active.
Gene_expression (generation) of LTC4 associated with ulcers
15) Confidence 0.26 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.84 Pain Relevance 0.08
Fundic LTB4 and LTC4 generation was similar in ulcer patients and controls.
Gene_expression (generation) of LTC4 associated with ulcers
16) Confidence 0.26 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.84 Pain Relevance 0.08
Platelet-activating factor (PAF), leukotriene B4 (LTB4), and leukotriene C4 (LTC4) generation by gastroduodenal mucosa was assessed in duodenal ulcer patients and in normal subjects, to elucidate their possible role in the pathogenesis of peptic ulcer disease.
Gene_expression (generation) of leukotriene C4 in Platelet associated with peptic ulcer disease, duodenal ulcer and disease
17) Confidence 0.26 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.57 Pain Relevance 0.09
Platelet-activating factor (PAF), leukotriene B4 (LTB4), and leukotriene C4 (LTC4) generation by gastroduodenal mucosa was assessed in duodenal ulcer patients and in normal subjects, to elucidate their possible role in the pathogenesis of peptic ulcer disease.
Gene_expression (generation) of LTC4 in Platelet associated with peptic ulcer disease, duodenal ulcer and disease
18) Confidence 0.26 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.57 Pain Relevance 0.09
Intraplantar injection of LTC4 at 0.8 pmol before the ??
Gene_expression (injection) of LTC4
19) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.35 Pain Relevance 0.39
We tested heat sensitivity of the hind paw after intraplantar injection of LTC4 (8 fmol, 0.8 pmol and 80 pmol).
Gene_expression (injection) of LTC4 in paw
20) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.44 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox