INT800

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Context Info
Confidence 0.42
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 10.30
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) oxidoreductase activity (Grhpr) cytoplasm (Grhpr)
Anatomy Link Frequency
liver 1
brain 1
neural 1
Grhpr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 14 99.84 Very High Very High Very High
Paracetamol 64 99.80 Very High Very High Very High
beta blocker 4 98.80 Very High Very High Very High
Pain 3 97.76 Very High Very High Very High
tolerance 13 95.36 Very High Very High Very High
Potency 17 91.60 High High
sSRI 1 90.76 High High
narcan 2 90.44 High High
antagonist 8 90.04 High High
opiate 1 89.60 High High
Disease Link Frequency Relevance Heat
Chromosome Aberrations 7 99.92 Very High Very High Very High
Muscle Disease 3 99.20 Very High Very High Very High
Toxicity 28 98.94 Very High Very High Very High
Increased Venous Pressure Under Development 114 98.72 Very High Very High Very High
Pain 2 97.76 Very High Very High Very High
Coronary Heart Disease 12 97.28 Very High Very High Very High
Disorders Of Creatine Metabolism 3 96.76 Very High Very High Very High
Cancer 20 96.44 Very High Very High Very High
Infection 14 96.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that paracetamol reduces DNA synthesis by a specific inhibition of ribonucleotide reductase.
Negative_regulation (inhibition) of reductase associated with paracetamol
1) Confidence 0.42 Published 1990 Journal Mutagenesis Section Abstract Doc Link 2175832 Disease Relevance 0.21 Pain Relevance 0.79
Paracetamol inhibits replicative DNA synthesis and induces sister chromatid exchange and chromosomal aberrations by inhibition of ribonucleotide reductase.
Negative_regulation (inhibition) of reductase associated with chromosome aberrations and paracetamol
2) Confidence 0.42 Published 1990 Journal Mutagenesis Section Title Doc Link 2175832 Disease Relevance 0.20 Pain Relevance 0.61
HU inhibits ribonucleotide reductase by destroying a tyrosyl free radical located on the small subunit of the enzyme.
Negative_regulation (inhibits) of reductase
3) Confidence 0.31 Published 1990 Journal Mutagenesis Section Abstract Doc Link 2175832 Disease Relevance 0.20 Pain Relevance 0.70
FUra (50 mg/kg)d plus CP (200 mg/kg) decreased neotetrazolium reductase activity 17% on Days 4 and 6 after treatment and the enzyme activity then returned to control levels on Day 8.
Negative_regulation (decreased) of neotetrazolium reductase
4) Confidence 0.04 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7447541 Disease Relevance 0.24 Pain Relevance 0.22
However, neotetrazolium reductase activity was decreased 15% on Day 2 and then returned to control levels on Day 4.
Negative_regulation (decreased) of neotetrazolium reductase
5) Confidence 0.04 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7447541 Disease Relevance 0.20 Pain Relevance 0.24
The diphosphate is a potent inhibitor of ribonucleotide reductase, an action that reduces deoxynucleotide pools.
Negative_regulation (inhibitor) of reductase
6) Confidence 0.03 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1180427 Disease Relevance 0.58 Pain Relevance 0.08
There was a decrease in the levels of super oxide dismutase (SOD) and glutathione reductase (GSH) in the brain.
Negative_regulation (decrease) of reductase in brain
7) Confidence 0.03 Published 2002 Journal Indian J. Exp. Biol. Section Abstract Doc Link 13677625 Disease Relevance 0.35 Pain Relevance 0.22
The aim of this study was to determine whether extrahepatic acetaminophen toxicity is altered in a mouse model that has liver-specific deletion of the NADPH-cytochrome P450 reductase (Cpr) gene.
Negative_regulation (deletion) of reductase in liver associated with toxicity and paracetamol
8) Confidence 0.02 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15550675 Disease Relevance 0.88 Pain Relevance 0.92
Ful pretreatment (225 mg.kg-1, sc x 3 d) decreased hepatic cytochrome P-450, cytochrome b5, and NADPH-cytochrome c reductase by approximately 15-20%.
Negative_regulation (decreased) of reductase
9) Confidence 0.02 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1442100 Disease Relevance 0.32 Pain Relevance 0.86
The levels of hepatic microsomal cytochrome P-450 and cytochrome b5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment.
Neg (unaffected) Negative_regulation (unaffected) of reductase associated with morphine
10) Confidence 0.02 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.17 Pain Relevance 1.14
Recent studies have revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase, the mitochondrial aldehyde dehydrogenase (ALDH-2), play an important role in the development of nitrate and cross-tolerance.
Negative_regulation (inactivation) of reductase associated with tolerance
11) Confidence 0.02 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19307691 Disease Relevance 0.55 Pain Relevance 0.35
On the other hand, AAP induced a significant decrease in NADH-ferricyanide reductase in mice, but not in rats.
Negative_regulation (decrease) of reductase associated with paracetamol
12) Confidence 0.01 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 100639 Disease Relevance 0 Pain Relevance 0.57
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase occasionally cause myopathy characterized by weakness, pain, and elevated serum creatine phosphokinase (CK).
Negative_regulation (Inhibitors) of reductase associated with pain, disorders of creatine metabolism and muscle disease
13) Confidence 0.01 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17327694 Disease Relevance 0.46 Pain Relevance 0.10
Hydroxyurea (HU) is a low molecular weight nonalkylating myelosuppressive agent that impairs DNA synthesis through the inhibition of ribonucleotide reductase [1].
Negative_regulation (inhibition) of reductase
14) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 0.54 Pain Relevance 0
In the latter treatment, HU does not have a direct anti-virus activity; rather, it inhibits the cellular enzyme ribonucleotide reductase and as a consequence, reduces deoxynucleotide triphosphates (dNTPs) that are necessary for DNA synthesis.
Negative_regulation (inhibits) of reductase
15) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 1.07 Pain Relevance 0
In the late 1970s, the search for a nonmutagenic myelosuppressive agent led the PVSG to investigate hydroxyurea (HU), an antimetabolite that prevents DNA synthesis by inhibiting the enzyme ribonucleoside reductase.
Negative_regulation (inhibiting) of reductase
16) Confidence 0.01 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780604 Disease Relevance 0.70 Pain Relevance 0
Studies were reported involving the prediction of dihydrofolate reductase inhibition based on data derived from high-throughput screening using preclustering and evolved neural networks (66) as well as applications for prescreening compounds for HIV inhibition while optimizing specificity and potency (67).
Negative_regulation (inhibition) of reductase in neural associated with acquired immune deficiency syndrome or hiv infection and potency
17) Confidence 0.01 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0.09 Pain Relevance 0.14
Furthermore, oral administration of CoQ10 increased also NADPH-CoQ reductase activity, which was decreased by statin administration (Fig. 2).
Negative_regulation (decreased) of reductase
18) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.06 Pain Relevance 0
Simvastatin also reduced the activity of NADPH-CoQ reductase, a biological enzyme that converts oxidized CoQ to the corresponding reduced CoQ, while CoQ10 administration improved it.
Negative_regulation (reduced) of reductase
19) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2275764 Disease Relevance 0.21 Pain Relevance 0
The patients with known vascular disease should be treated aggressively with a combination of a HMG CoA reductase inhibitor, an angiotensin-converting enzyme inhibitor, an antiplatelet agent and a beta blocker if there is a history of coronary disease.
Negative_regulation (inhibitor) of reductase associated with beta blocker, coronary heart disease and increased venous pressure under development
20) Confidence 0.01 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 1.49 Pain Relevance 0.12

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