INT80283

Context Info Confidence 0.29 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.24

signal transduction (TNF, CCL13) extracellular space (TNF, CCL13) extracellular region (TNF, CCL13) plasma membrane (TNF) intracellular (TNF) cytoskeleton organization (CCL13)

Anatomy Link Frequency fibroblasts 2 TNF (Homo sapiens) CCL13 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 1 90.72 chemokine 3 75.00 Inflammation 1 73.96

Disease Link Frequency Relevance Heat INFLAMMATION 2 90.48 Rhinitis 2 75.00 Disease 1 74.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Like MCP-3, MCP-4 mRNA expression in dermal fibroblasts is upregulated by TNF-alpha, IL-1alpha, IFN-gamma or IL-4 and differs from RANTES and eotaxin mRNA expression in its response to IFN-gamma and/or IL-4.

TNF-alpha Positive_regulation (upregulated) of Gene_expression (expression) of MCP-4 mRNA in fibroblasts

1) Confidence 0.29 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.39 Pain Relevance 0.24

General Comments

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