INT80320

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.85
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
dorsal 2
raphe nucleus 2
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 47 100.00 Very High Very High Very High
fluoxetine 67 99.70 Very High Very High Very High
Raphe 13 99.56 Very High Very High Very High
amygdala 12 97.96 Very High Very High Very High
Cannabinoid 3 95.64 Very High Very High Very High
Hippocampus 36 95.56 Very High Very High Very High
antidepressant 230 95.00 High High
bDMF 64 94.40 High High
cocaine 6 94.20 High High
Opioid 2 93.92 High High
Disease Link Frequency Relevance Heat
Depression 182 91.52 High High
Disease 4 75.00 Quite High
Shock 6 73.68 Quite High
Urological Neuroanatomy 8 69.52 Quite High
Aids-related Complex 7 57.12 Quite High
Targeted Disruption 54 53.92 Quite High
Stress 20 41.00 Quite Low
Cognitive Disorder 4 40.64 Quite Low
Neurodegenerative Disease 14 5.00 Very Low Very Low Very Low
Hypothermia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry was used to delineate serotonin transporter messenger RNA expression during rat embryonic development.
Negative_regulation (delineate) of Gene_expression (expression) of serotonin transporter messenger RNA associated with serotonin
1) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.51
Treatment with fluoxetine progressively decreased (35-55%) 5-HTT gene expression in dorsal raphe nucleus at 8, 16 and 31 days.
Negative_regulation (decreased) of Gene_expression (expression) of 5-HTT in raphe nucleus associated with raphe and fluoxetine
2) Confidence 0.12 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15936043 Disease Relevance 0.06 Pain Relevance 0.82
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
Negative_regulation (inhibitor) of Gene_expression (synthesized) of serotonin transporter associated with serotonin
3) Confidence 0.10 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.21
Northern blot analysis indicated that 5-HTT gene expression is suppressed in the 5-HT depleted state [168] indicating a trophic role for 5-HT.
Negative_regulation (suppressed) of Gene_expression (expression) of 5-HTT
4) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.29 Pain Relevance 0.54
Fluoxetine treatment down-regulates the expression of many proteins involved in the multiple kinase pathways determining 5-HTT regulation [254] and is shown to decrease the 5-HTT expression in rat dorsal raphae nucleus [233].
Negative_regulation (decrease) of Gene_expression (expression) of 5-HTT in dorsal associated with fluoxetine
5) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.43 Pain Relevance 0.52

General Comments

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