INT80329

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 20.96
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD) plasma membrane (THBD) embryo development (THBD)
Anatomy Link Frequency
endothelial cells 5
plasma 2
blood 1
coronary artery 1
lining cells 1
THBD (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 10 98.72 Very High Very High Very High
tolerance 20 97.68 Very High Very High Very High
Restless leg syndrome 3 97.12 Very High Very High Very High
Inflammation 105 91.12 High High
aspirin 22 90.12 High High
Paracetamol 6 87.92 High High
Inflammatory response 2 87.52 High High
cva 43 84.08 Quite High
headache 2 82.68 Quite High
imagery 5 75.48 Quite High
Disease Link Frequency Relevance Heat
Adhesions 35 100.00 Very High Very High Very High
Peripheral Arterial Disease 28 99.94 Very High Very High Very High
Pulmonary Hypertension 45 99.86 Very High Very High Very High
Systemic Sclerosis 535 99.84 Very High Very High Very High
Disease 167 99.80 Very High Very High Very High
Atherosclerosis 155 99.62 Very High Very High Very High
Thrombosis 18 99.62 Very High Very High Very High
Cyst 7 99.62 Very High Very High Very High
Pancreatitis 44 99.48 Very High Very High Very High
Injury 18 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating (c)E-selectin levels increased by 820%, von Willebrand factor-Ag (vWF), soluble thrombomodulin, circulating (c)P-selectin, circulating intercellular adhesion molecule-1 (cICAM-1), and circulating vascular cell adhesion molecule-1 (cVCAM-1) by a mean of 65 to 98% (p < 0.001 for all), but cL-selectin by only 15%.
Positive_regulation (increased) of thrombomodulin associated with adhesions
1) Confidence 0.47 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 1.09 Pain Relevance 0.32
The cytoplasm of some of the atypical endothelial cells was immunohistochemically positive for vimentin, factor VIII-related antigen, CD 34, and thrombomodulin.
Positive_regulation (positive) of thrombomodulin in endothelial cells
2) Confidence 0.45 Published 1998 Journal Brain Tumor Pathol Section Abstract Doc Link 10328547 Disease Relevance 0.39 Pain Relevance 0.08
In sera of patients with PAH, high concentrations of thrombomodulin (TM) and von Willebrand factor antigen (vWFAg) secreted from Weibel-Palade bodies imply an activated state of the endothelial cells.
Positive_regulation (concentrations) of thrombomodulin in endothelial cells associated with pulmonary hypertension
3) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.48 Pain Relevance 0.16
In sera of patients with PAH, high concentrations of thrombomodulin (TM) and von Willebrand factor antigen (vWFAg) secreted from Weibel-Palade bodies imply an activated state of the endothelial cells.
Positive_regulation (concentrations) of TM in endothelial cells associated with pulmonary hypertension
4) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.48 Pain Relevance 0.16
Circulating (c)E-selectin levels increased by 820%, von Willebrand factor-Ag (vWF), soluble thrombomodulin, circulating (c)P-selectin, circulating intercellular adhesion molecule-1 (cICAM-1), and circulating vascular cell adhesion molecule-1 (cVCAM-1) by a mean of 65 to 98% (p < 0.001 for all), but cL-selectin by only 15%.
Positive_regulation (circulating) of thrombomodulin associated with adhesions
5) Confidence 0.34 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10051263 Disease Relevance 1.16 Pain Relevance 0.36
Soluble TM can be measured in peripheral blood, and an elevated level of soluble TM is a marker of endothelial injury.
Positive_regulation (elevated) of TM in blood associated with injury
6) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.16 Pain Relevance 0.06
Anti-U1RNP autoantibodies, anti-CL IgG/IgM type autoantibodies, AECA and both endothelial cell markers (TM and vWFAg) were significant increased in MCTD patients versus controls and in the MCTD/CVD+ versus MCTD/CVD- patient groups (Table 3).
Positive_regulation (increased) of TM in endothelial cell associated with cardiovascular disease and systemic sclerosis
7) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.94 Pain Relevance 0.07
In patients with atherosclerotic diseases, soluble TM was elevated and its level showed correlation with the severity of coronary artery disease, and also an association with worse outcome in survivals after acute myocardial infarction [42].
Positive_regulation (elevated) of TM in coronary artery associated with cardiovascular disease, atherosclerosis, disease and myocardial infarction
8) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.32 Pain Relevance 0.06
Immunostaining showed that the cyst lining cells were positive for keratin, vimentin, HBME-1, WT1, and thrombomodulin but negative for carcinoembryonic antigen, B72.3, Leu-M1, and BerEP4.
Positive_regulation (positive) of thrombomodulin in lining cells associated with cyst
9) Confidence 0.31 Published 2000 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 10782166 Disease Relevance 0.79 Pain Relevance 0.26
With regard to peripheral arterial disease (PAD), thrombomodulin blood levels, for example, were not significantly elevated in patients with critical limb ischemia in comparison to patients with intermittent claudication.
Neg (not) Positive_regulation (elevated) of thrombomodulin in limb associated with restless leg syndrome, ischemia and peripheral arterial disease
10) Confidence 0.19 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 1.05 Pain Relevance 0.15
An increase in plasma-soluble thrombomodulin predicted a lethal course of AP [16].
Positive_regulation (increase) of thrombomodulin in plasma associated with pancreatitis
11) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.19 Pain Relevance 0.18
Increased TM level in guinea pig's plasma may reflect the injury of endothelial cells in leptospirosis.
Positive_regulation (Increased) of TM in endothelial cells associated with leptospirosis and injury
12) Confidence 0.14 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434752 Disease Relevance 1.48 Pain Relevance 0.12
Tissue factor pathway inhibitor TFPI activity and thrombomodulin levels were increased in all elderly subjects, with positive association between HbA (1c), TFPI activity and vWF antigen.
Positive_regulation (increased) of thrombomodulin
13) Confidence 0.13 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.16 Pain Relevance 0.21
The first case of HO-1 deficiency in human was identified in 1999 [14], the patient suffered persistent hemolytic anemia and abnormal coagulation/fibrinolysis system associated with elevated thrombomodulin and von Willebrand factor, indicating persistent vascular injury.
Positive_regulation (elevated) of thrombomodulin associated with hemolytic anemia and vasculitis
14) Confidence 0.11 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.69 Pain Relevance 0.16
Moreover, pitavastatin is reported to have an inhibitory effect on plasminogen activator inihibitor-1 (PAI-1)22,23 and tissue factor (TF)23 which are important factors in thrombosis formation, and to induce tissue plasminogen activator (t-PA)23 and thrombomodulin (TM) expression.22,24 Therefore, pitavastatin is expected to exert its anti-atherosclerotic effect via various mechanisms.
Positive_regulation (induce) of thrombomodulin associated with atherosclerosis and thrombosis
15) Confidence 0.10 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.37 Pain Relevance 0.08
Analysis of hematologic molecular markers showed that 11-DH-TXB2 and TM in the plasma were elevated significantly.
Positive_regulation (elevated) of TM in plasma
16) Confidence 0.09 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1434752 Disease Relevance 1.03 Pain Relevance 0.03

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