INT80420

Context Info Confidence 0.78 First Reported 1999 Last Reported 2010 Negated 7 Speculated 4 Reported most in Body Documents 145 Total Number 149 Disease Relevance 63.61 Pain Relevance 8.83

mitochondrion (IFI27) molecular_function (IFI27)

Anatomy Link Frequency muscle fibers 9 muscle cells 8 epithelium 5 plasma 4 skeletal muscle 4 IFI27 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 130 99.82 dexamethasone 16 99.36 Spinal cord 146 99.20 aspirin 14 98.80 COX2 14 98.28 psoriasis 19 97.68 Dynorphin 1 96.56 peptic ulcer disease 1 96.00 Inflammation 91 95.04 Morphine 1 94.72

Disease Link Frequency Relevance Heat Retinoblastoma 195 100.00 Cancer 2293 99.98 Apoptosis 563 99.96 Gastritis 3 99.92 Psoriasis 25 99.84 Endometrial Cancer 33 99.80 INFLAMMATION 133 99.72 Mesothelioma 33 99.64 Hypertrophy 700 99.58 Adenocarcinoma 306 99.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: Darbufelone inhibited the proliferation of non-small cell lung cancer cell lines in a dose-dependent manner, and induced cell cycle arrest at G0/G1 phase through up-regulation of p27 expression.

Gene_expression (expression) of p27 in lung

1) Confidence 0.78 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0

Immunohistochemical staining of affected tissues revealed consistent expression of FeLV p27 antigens in neurons, endothelial cells, and glial cells.

Gene_expression (expression) of p27 in endothelial cells

2) Confidence 0.77 Published 2002 Journal Vet. Pathol. Section Abstract Doc Link 12243463 Disease Relevance 1.02 Pain Relevance 0.20

1 and p27 expression did not show a significant influence on the survival of patients.

Gene_expression (expression) of p27

3) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.48 Pain Relevance 0

The percentage of cells expressing p27 was recorded as the ratio of positive cells-to-the total number of cells counted. p27 expression was grouped as high or low.

Gene_expression (expression) of p27

4) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.39 Pain Relevance 0

Also anomalous overexpression of p27 in human pancreatic endocrine tumors were reported [25].

Gene_expression (overexpression) of p27 associated with cancer

5) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 1.29 Pain Relevance 0

On the other hand, there was no association between p27 expression and other clinicopathologic parameters.

Gene_expression (expression) of p27

6) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.65 Pain Relevance 0

Inverse correlation between p27 expression and tumor grade, lymph node metastasis and stage of tumor was reported [14].

Gene_expression (expression) of p27 in lymph node associated with cancer and metastasis

7) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 1.25 Pain Relevance 0

In a few reports, p27 and p21 staining did not correlate significantly with any clinicopathologic parameters [28,29], but there was an association between p27 and cyclin D1 expression indicating that the balance between the two opposing regulators was important for the end result of cell cycle progression [22].

Gene_expression (expression) of p27

8) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.91 Pain Relevance 0

1 nor p27 expression was related with patient survival.

Gene_expression (expression) of p27

9) Confidence 0.73 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1208869 Disease Relevance 0.71 Pain Relevance 0

Cells that had either weak or strong nuclear staining were considered to be positive for p27 protein expression.

Gene_expression (expression) of p27

10) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.39 Pain Relevance 0

Additionally, although the difference was not statistically significant, p27 was dominantly expressed in low stage tumors.

Gene_expression (expressed) of p27 associated with cancer

11) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 1.01 Pain Relevance 0

The percentage of cells expressing p27 was recorded as the ratio of positive cells-to-the total number of cells counted. p27 expression was grouped as high or low.

Gene_expression (expressing) of p27

12) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.39 Pain Relevance 0

Patients with low p27 expression had less than 30% of the nuclei in the specimen staining positive, while those with high levels of p27 expression had more than 30% of the nuclei staining for the bound antibody [15].

Gene_expression (expression) of p27

13) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.40 Pain Relevance 0

In the present study we could not find any relation between p27 and cyclin D1 expression.

Gene_expression (expression) of p27

14) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.63 Pain Relevance 0

Lu et al demonstrated that loss of p27 expression independently predicts a poor prognosis for patients with resectable pancreatic adenocarcinomas [24].

Gene_expression (expression) of p27 associated with adenocarcinoma

15) Confidence 0.73 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 1.22 Pain Relevance 0

Yet, the cytoplasmic p27 expression in abnormal skeletal muscles also appears to be temporary, i.e., during the transition (type II to type I) and terminal regression of myotubes.

Gene_expression (expression) of p27 in skeletal muscles

16) Confidence 0.72 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0

This was accompanied by p27 cytoplasmic expression in t2 fibers.

Gene_expression (expression) of p27

17) Confidence 0.72 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.15 Pain Relevance 0

Quantitative evaluation of p27 expression

Gene_expression (expression) of p27

18) Confidence 0.72 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.26 Pain Relevance 0

Altogether, these observations indicate that, in addition to the striated muscle cells, the cytoplasmic and plasma membrane p27 expression can be observed (under certain circumstances) in other cell types.

Gene_expression (expression) of p27 in plasma

19) Confidence 0.72 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0

Moreover, a combined action of estrogens and progesterone, characteristic for the luteal phase, appears to cause a diminution of nuclear p27 expression in the epithelium of ectocervix and endometrium (Fig. 9, C and 9F).

Gene_expression (expression) of p27 in epithelium

20) Confidence 0.72 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0

General Comments

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