INT80450

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPR) small molecule metabolic process (SPR) oxidoreductase activity (SPR)
nucleolus (SPR) nucleus (SPR) cytoplasm (SPR)
Anatomy Link Frequency
plasma 1
SPR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
substance P 6 99.48 Very High Very High Very High
agonist 4 99.24 Very High Very High Very High
Kinase C 4 97.64 Very High Very High Very High
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spasticity 3 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
Stroke 3 99.56 Very High Very High Very High
Hemiplegia 1 99.38 Very High Very High Very High
Cerebral Palsy 1 93.48 High High
Disease 79 11.76 Low Low
Pulmonary Disease 93 5.00 Very Low Very Low Very Low
Nicotine Addiction 7 5.00 Very Low Very Low Very Low
Airway Obstruction 4 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe two elderly patients with hemiplegia who underwent unilateral SPR for pain caused by spasticity after stroke.
Positive_regulation (underwent) of SPR associated with pain, spasticity, stroke and hemiplegia
1) Confidence 0.41 Published 2004 Journal Neurosurgery Section Abstract Doc Link 15113485 Disease Relevance 0.74 Pain Relevance 0.17
We investigate the real-time activation and desensitization of the human SPR in live HEK293 cells using green fluorescent protein conjugates of protein kinase C, GRK2, and beta-arrestin 2.
Spec (investigate) Positive_regulation (activation) of SPR associated with kinase c
2) Confidence 0.28 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10066824 Disease Relevance 0.08 Pain Relevance 0.38
The translocation of protein kinase C betaII-green fluorescent protein to and from the plasma membrane in response to substance P indicates that the human SPR becomes activated within seconds of agonist exposure, and the response desensitizes within 30 s.
Positive_regulation (activated) of SPR in plasma associated with kinase c, agonist and substance p
3) Confidence 0.28 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10066824 Disease Relevance 0.07 Pain Relevance 0.38
The use of SPR for the detection of biomolecules
Positive_regulation (use) of SPR
4) Confidence 0.08 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0 Pain Relevance 0

General Comments

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