INT8066

Context Info Confidence 0.36 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 4.65 Pain Relevance 0.58

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

Anatomy Link Frequency plasma 2 brain 1 lung 1 body 1 RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Neurotransmitter 2 99.52 antagonist 4 93.92 Pain 3 88.12 Bile 6 74.80 palliative 8 62.48 Inflammation 3 58.16 ischemia 12 42.68 Central nervous system 3 40.48 peripheral neuropathy 6 5.00 Catecholamine 3 5.00

Disease Link Frequency Relevance Heat Hypertension 11 99.66 Breast Cancer 61 99.08 Lung Cancer 84 98.88 Sepsis 44 98.20 Critical Illness 1 97.96 Non-small-cell Lung Cancer 15 94.44 Adhesions 3 93.96 Cancer 152 91.44 Neurological Disease 3 89.16 Pain 3 88.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this way the brain RAS interacts with other neurotransmitter and neuromodulator systems and contributes to the regulation of blood pressure, body fluid homeostasis, cyclicity of reproductive hormones and sexual behavior, and perhaps plays a role in other functions such as memory acquisition and recall, sensory acuity including pain perception and exploratory behavior.

RAS Binding (interacts) of in body associated with pain and neurotransmitter

1) Confidence 0.36 Published 1992 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 1361394 Disease Relevance 0.27 Pain Relevance 0.14

Antibodies bound to RAs were visualized using NBT/BCIP-based substrate (Promega, Madison, WI, USA).

RAs Binding (bound) of

2) Confidence 0.30 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0 Pain Relevance 0

[Mutations of ras and p53 genes in human non-small cell lung cancer cell lines and their clinical significance].

ras Binding ([Mutations) of in lung associated with lung cancer

3) Confidence 0.26 Published 1992 Journal Nippon Geka Gakkai Zasshi Section Title Doc Link 1361656 Disease Relevance 0.36 Pain Relevance 0.06

Oral treatment with angiotensin-converting enzyme inhibitors, which interfere with the formation of angiotensin II, prevents the development of hypertension in young SHR by acting, at least in part, upon the brain RAS.

RAS Binding (acting) of in brain associated with hypertension

4) Confidence 0.24 Published 1992 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 1361394 Disease Relevance 0.54 Pain Relevance 0.17

In this context, the aim of our study was to evaluate whether breast cancer patients whose sera or immunocompetent cells recognize RAs display any visual impairments.

RAs Binding (recognize) of associated with breast cancer

5) Confidence 0.23 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0.74 Pain Relevance 0

Our studies provide evidence of associations between RAS and relevant microvascular perturbations in sepsis.

RAS Binding (associations) of associated with sepsis

6) Confidence 0.21 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.72 Pain Relevance 0.03

The homogenate was centrifuged at 30,000×g for 30 min at 4°C and supernatant containing soluble proteins (the retinal extract) was collected and further used as a source of RAs.

RAs Binding (source) of

7) Confidence 0.20 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0.06 Pain Relevance 0

The blockade of Ras binding to the plasma membrane may therefore be a good therapeutic target for the treatment of malignancies [22].

Ras Binding (binding) of in plasma

8) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.28 Pain Relevance 0.05

The ras protein is known to undergo a series of post-translational modifications at the c-terminal CAAX motif, which forms a thioether bond of p21 ras with farnesyl and ties it to the plasma membrane [117].

ras Binding (bond) of in plasma

9) Confidence 0.02 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.46 Pain Relevance 0

Constitutively activated Ras is associated with continuous growth stimulation.

Ras Binding (associated) of

10) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.23 Pain Relevance 0.13

General Comments

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