INT80882

Context Info Confidence 0.45 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.21 Pain Relevance 3.68

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)

OPRM1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 279 100.00 agonist 33 100.00 Enkephalin 21 100.00 antagonist 78 99.10 potassium channel 8 97.96 analgesia 41 89.60 Glutamate receptor 3 84.20 Opioid 27 83.76 MU agonist 4 83.16 narcan 2 75.32

Disease Link Frequency Relevance Heat Neuroblastoma 2 85.84 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 30 60.32 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 64 5.00 Pain 22 5.00 Nociception 14 5.00 Toxicity 2 5.00 Disease 2 5.00 Colitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation.

Negative_regulation (loss) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist, opioid receptor and enkephalin

1) Confidence 0.45 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10092593 Disease Relevance 0.09 Pain Relevance 0.85

However, in MOR/ mGluR5 co-expressing cells, the non-competitive mGluR5 antagonist MPEP (2-methyl-6-(phenyl-ethynyl)-pyridine) decreases the DAMGO-induced MOR phosphorylation, internalization, and desensitization, whereas non-selective competitive mGluR antagonists or agonists had no effects.

Negative_regulation (decreases) of Phosphorylation (phosphorylation) of MOR associated with antagonist, agonist and opioid receptor

2) Confidence 0.40 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.03

Thus, these data show that phosphorylation of MOR1TAG is not an obligatory event for the DAMGO-induced loss in the adenylyl cyclase regulation by the receptor.

Negative_regulation (event) of Phosphorylation (phosphorylation) of MOR1TAG

3) Confidence 0.33 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0 Pain Relevance 0.39

Moreover, glibenclamide inhibits both MOR and AKT phosphorylation induced by hydrogen sulphide, demonstrating that activation of ATP potassium channels by hydrogen sulphide is a key process of these effects.

Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of MOR associated with potassium channel and opioid receptor

4) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.89

Thus not only SKNMCs express SUR1 and Kir6.2, but blocking these channels with glibenclamide abrogates AKT phosphorylation and MOR activation and internalization induced by H2S.

Negative_regulation (abrogates) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor

5) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.51

General Comments

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