INT80882

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.21
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 279 100.00 Very High Very High Very High
agonist 33 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
antagonist 78 99.10 Very High Very High Very High
potassium channel 8 97.96 Very High Very High Very High
analgesia 41 89.60 High High
Glutamate receptor 3 84.20 Quite High
Opioid 27 83.76 Quite High
MU agonist 4 83.16 Quite High
narcan 2 75.32 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 85.84 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

30 60.32 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

64 5.00 Very Low Very Low Very Low
Pain 22 5.00 Very Low Very Low Very Low
Nociception 14 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Colitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation.
Negative_regulation (loss) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist, opioid receptor and enkephalin
1) Confidence 0.45 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10092593 Disease Relevance 0.09 Pain Relevance 0.85
However, in MOR/ mGluR5 co-expressing cells, the non-competitive mGluR5 antagonist MPEP (2-methyl-6-(phenyl-ethynyl)-pyridine) decreases the DAMGO-induced MOR phosphorylation, internalization, and desensitization, whereas non-selective competitive mGluR antagonists or agonists had no effects.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of MOR associated with antagonist, agonist and opioid receptor
2) Confidence 0.40 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.03
Thus, these data show that phosphorylation of MOR1TAG is not an obligatory event for the DAMGO-induced loss in the adenylyl cyclase regulation by the receptor.
Negative_regulation (event) of Phosphorylation (phosphorylation) of MOR1TAG
3) Confidence 0.33 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0 Pain Relevance 0.39
Moreover, glibenclamide inhibits both MOR and AKT phosphorylation induced by hydrogen sulphide, demonstrating that activation of ATP potassium channels by hydrogen sulphide is a key process of these effects.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of MOR associated with potassium channel and opioid receptor
4) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.89
Thus not only SKNMCs express SUR1 and Kir6.2, but blocking these channels with glibenclamide abrogates AKT phosphorylation and MOR activation and internalization induced by H2S.
Negative_regulation (abrogates) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor
5) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.51

General Comments

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