INT8098

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.79
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
plasma membrane (ERBB3) nucleus (ERBB3)
Anatomy Link Frequency
MDA-MB-231 4
hepatocyte 2
exocrine pancreas 2
astrocytes 2
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 97.04 Very High Very High Very High
antagonist 2 26.16 Quite Low
cINOD 2 15.36 Low Low
COX-2 inhibitor 40 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 127 100.00 Very High Very High Very High
Anaplastic Astrocytoma 84 99.40 Very High Very High Very High
Carcinoma 1 98.92 Very High Very High Very High
Cancer 123 98.84 Very High Very High Very High
Glioblastoma 24 97.72 Very High Very High Very High
Glioma 6 97.04 Very High Very High Very High
Pancreatitis 1 97.04 Very High Very High Very High
Breast Cancer 27 94.16 High High
Neuroepithelial Neoplasms 3 91.56 High High
Pancreatic Cancer 3 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of erbB-3 protein in exocrine pancreas associated with carcinoma and chronic pancreatitis
1) Confidence 0.69 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1361525 Disease Relevance 0.54 Pain Relevance 0.10
Cancer cells expressing EGFR and ErbB2 are nonresponsive to inhibitors targeting one of these two proteins.63 Similarly, overexpression of ErbB3 also confers resistance to EGFR inhibitors.64 Expression of hepatocyte growth factor and c-Met dependent signaling is also an alternative pathway for signaling conferring resistance (seen in approximately 20% of patients with acquired resistance to TKIs).65 Finally, interactions between EGFR and the insulin growth factor receptor (IGF-1R) can provide resistance to agents targeting EGFR.66
Positive_regulation (overexpression) of Gene_expression (overexpression) of ErbB3 in hepatocyte associated with cancer
2) Confidence 0.50 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.36 Pain Relevance 0
The overexpression of c-erbB3 and c-erbB4 is in accordance with our previous study on glioblastomas as well as with others [8,21,54,59,60].
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-erbB3 associated with glioblastoma
3) Confidence 0.41 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.88 Pain Relevance 0
Due to overexpression of the c-erbB1-4 receptor proteins and their location on the surface of neoplastic astrocytes, they are attractive candidates for targeted therapy [11-13].
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-erbB1 in astrocytes
4) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.85 Pain Relevance 0
The synchronous overexpression of c-erbB1-4 proteins in anaplastic astrocytomas supports their role in the pathogenesis of these tumors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-erbB1 associated with anaplastic astrocytoma and cancer
5) Confidence 0.33 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2859381 Disease Relevance 0.37 Pain Relevance 0
Celecoxib induces apoptosis in MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants
Positive_regulation (induces) of Gene_expression (transfectants) of MDA-MB-231 in MDA-MB-231 associated with apoptosis
6) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.10 Pain Relevance 0
These results suggest that celecoxib induces apoptosis in MDA-MB-231-E1A and MDA-MB-435-E1A stable transfectants regardless of Bcl-2 expression.


Positive_regulation (induces) of Gene_expression (transfectants) of MDA-MB-231 in MDA-MB-231 associated with apoptosis
7) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.69 Pain Relevance 0

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