INT81043

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.68
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Kctd1) transcription factor binding (Kctd1)
Anatomy Link Frequency
apoptotic cell 1
Kctd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 11 99.82 Very High Very High Very High
cva 8 98.92 Very High Very High Very High
headache 4 88.56 High High
imagery 8 83.92 Quite High
sodium channel 1 77.12 Quite High
Lasting pain 1 76.20 Quite High
Pain 2 75.76 Quite High
tricyclic antidepressant 1 73.88 Quite High
Inflammatory response 3 67.40 Quite High
cINOD 12 57.24 Quite High
Disease Link Frequency Relevance Heat
Vascular Dementia 56 100.00 Very High Very High Very High
Vertebral Artery Dissection 6 100.00 Very High Very High Very High
Apoptosis 282 99.92 Very High Very High Very High
Infection 24 99.40 Very High Very High Very High
Stroke 38 99.32 Very High Very High Very High
Cv General 3 Under Development 8 98.92 Very High Very High Very High
Death 54 98.78 Very High Very High Very High
Cognitive Disorder 40 97.32 Very High Very High Very High
Amebic Liver Abscess 4 95.92 Very High Very High Very High
Brain Hemorrhage 1 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we investigated accepted markers of apoptosis (mitochondrial membrane potential, cytosolic cytochrome c, and activated caspase-3) and co-incubated amitriptyline with an inhibitor of caspase activity, z-vad-fmk, to assess the effect on cell survival.
Negative_regulation (inhibitor) of vad associated with apoptosis and endep
1) Confidence 0.57 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717317 Disease Relevance 0.75 Pain Relevance 0.59
This triptolide-induced activation of caspase-3 was suppressed by Z-VAD-FMK, a pan-caspase inhibitor.
Negative_regulation (inhibitor) of VAD
2) Confidence 0.42 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.81 Pain Relevance 0.06
RSF were incubated in tissue culture flask with or without triptolide and/or Z-VAD-FMK (a pan-caspase inhibitor) in the condition described above.
Negative_regulation (inhibitor) of VAD
3) Confidence 0.42 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.23 Pain Relevance 0
The role of apoptotic cell death was also documented by the treatment of mice with a caspase inhibitor (Z-VAD-fmk) prior to infection with E. histolytica [43].
Negative_regulation (inhibitor) of VAD in apoptotic cell associated with apoptosis, infection and death
4) Confidence 0.42 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.68 Pain Relevance 0.03
A total number of VAD was 22, a total number of cerebrovascular events - 15.
Negative_regulation (number) of VAD associated with vertebral artery dissection and cva
5) Confidence 0.36 Published 2007 Journal Zh Nevrol Psikhiatr Im S S Korsakova Section Abstract Doc Link 18379492 Disease Relevance 1.26 Pain Relevance 0.38
Other less studied strategies for prevention of VaD focus on prompt stroke diagnosis and treatment and good after care.
Negative_regulation (prevention) of VaD associated with vascular dementia and stroke
6) Confidence 0.05 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2695177 Disease Relevance 1.79 Pain Relevance 0
Z-VAD.FMK, a pancaspase inhibitor, and NO donors protected from acute damage induced by aspirin.
Negative_regulation (inhibitor) of Z-VAD
7) Confidence 0.03 Published 1999 Journal Gastroenterology Section Body Doc Link 10220501 Disease Relevance 0 Pain Relevance 0
Z-VAD, a pan-caspase inhibitor, has no significant effects on METH-induced inhibition of proliferation but prevents the METH-induced apoptosis (data not shown).
Negative_regulation (inhibitor) of Z-VAD associated with apoptosis
8) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677674 Disease Relevance 1.15 Pain Relevance 0
Exposure to TNFalpha resulted in a time- and concentration-dependent HUVEC apoptosis, an effect that was prevented by pretreating the cells with NCX-4016, NO-naproxen, NO-flurbiprofen, SNP or Z-VAD.FMK, a pan-caspase inhibitor.
Negative_regulation (inhibitor) of Z-VAD
9) Confidence 0.00 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10102977 Disease Relevance 0 Pain Relevance 0

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