INT81086

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 7.51
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
neurons 3
Muscle 2
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 66 100.00 Very High Very High Very High
Inflammation 66 99.64 Very High Very High Very High
ischemia 10 99.48 Very High Very High Very High
tissue acidosis 1 99.12 Very High Very High Very High
Root ganglion neuron 5 98.96 Very High Very High Very High
agonist 4 98.60 Very High Very High Very High
Pain 43 97.96 Very High Very High Very High
Central nervous system 1 94.72 High High
Hyperalgesia 44 92.80 High High
Mechanotransduction 3 85.76 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 99.86 Very High Very High Very High
INFLAMMATION 70 99.64 Very High Very High Very High
Cv Unclassified Under Development 5 99.48 Very High Very High Very High
Acidosis 33 99.12 Very High Very High Very High
Ganglion Cysts 24 98.76 Very High Very High Very High
Pain 38 97.96 Very High Very High Very High
Hyperalgesia 44 93.60 High High
Myalgia 4 90.08 High High
Injury 18 87.04 High High
Hypersensitivity 1 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar mRNA increases were observed after inflammation in knockout mice: ASIC2 mRNA increases in ASIC3-/- mice; ASIC2 and ASIC3 mRNAs increase in ASIC1-/- mice.
Positive_regulation (increase) of ASIC2 associated with targeted disruption and inflammation
1) Confidence 0.65 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.46 Pain Relevance 0.85
Similar mRNA increases were observed after inflammation in knockout mice: ASIC2 mRNA increases in ASIC3-/- mice; ASIC2 and ASIC3 mRNAs increase in ASIC1-/- mice.
Positive_regulation (increases) of ASIC2 associated with targeted disruption and inflammation
2) Confidence 0.65 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.44 Pain Relevance 0.82
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Neg (not) Positive_regulation (increases) of ASIC2 in Muscle associated with inflammation
3) Confidence 0.65 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.18 Pain Relevance 0.58
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Neg (not) Positive_regulation (increases) of ASIC1b in Muscle associated with inflammation
4) Confidence 0.65 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.26 Pain Relevance 0.64
In particular ASIC3, the least abundant in the general population, is the most abundant ASIC transcript in colonic neurons.
Positive_regulation (abundant) of ASIC in neurons associated with asic
5) Confidence 0.41 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.25
One found ASIC3 and ASIC2 to co-localize in dorsal root ganglion neurons and to be present more often in larger neurons than in smaller [21].
Positive_regulation (found) of ASIC2 in neurons associated with ganglion cysts and root ganglion neuron
6) Confidence 0.08 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 1.24 Pain Relevance 0.89
A splice variant of ASIC2, ASIC2b, is not active on its own but modifies the properties of ASIC3.
Neg (not) Positive_regulation (active) of ASIC2
7) Confidence 0.08 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10187795 Disease Relevance 0.20 Pain Relevance 0.24
Moreover, lactate produced by anaerobic metabolism reduces extracellular Ca2+ concentration and results in the enhancement of the acid-induced ASIC currents in ischemia-sensing neurons [39].
Positive_regulation (induced) of ASIC in neurons associated with ischemia and asic
8) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.28 Pain Relevance 0.13
We found that pH 7.0 significantly potentiated AGM response and the potentiation was always more than additive with pH reduction regardless the sequence of agonist application (Figure 2D, E), a characteristic that is opposite to the accelerated ASIC desensitization caused by pretreatment with acidic solution [36].
Positive_regulation (accelerated) of ASIC associated with agonist and asic
9) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.45 Pain Relevance 0.22

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