INT81103

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.07
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tk1) kinase activity (Tk1) cytoplasm (Tk1)
Tk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 8 98.64 Very High Very High Very High
Opioid 1 88.40 High High
Immobilon 2 84.40 Quite High
MU agonist 1 84.00 Quite High
Bioavailability 3 81.96 Quite High
Delta opioid receptors 1 79.84 Quite High
neuralgia 3 67.84 Quite High
Post herpetic neuralgia 3 65.52 Quite High
Shingles 3 60.20 Quite High
Disease Link Frequency Relevance Heat
Herpes Zoster 48 98.20 Very High Very High Very High
Infection 15 98.04 Very High Very High Very High
Sprains And Strains 3 84.80 Quite High
Leukemia 3 82.72 Quite High
Chronic Disease 3 76.80 Quite High
Cancer 3 70.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 69.24 Quite High
Neuralgia 6 67.84 Quite High
Herpes Simplex Virus Infection 3 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down regulation involved phosphorylation and at least two different kinases, a tyrosine kinase (TK) and MAPK kinase (MEK), mediated DOR down regulation in parallel routes.
Phosphorylation (phosphorylation) of TK associated with opioid receptor
1) Confidence 0.40 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.58
As with aciclovir itself, all of these drugs are dependent on the virus-encoded thymidine kinase (TK) for their intracellular activation (phosphorylation), and, upon conversion to their triphosphate form, they act as inhibitors/alternative substrate of the viral DNA polymerase.
Phosphorylation (phosphorylation) of TK
2) Confidence 0.06 Published 1999 Journal Drugs Section Abstract Doc Link 10188760 Disease Relevance 1.42 Pain Relevance 0.14
Other classes of nucleoside analogues dependent for their phosphorylation on the viral TK that have been pursued for the treatment of VZV infections include sorivudine, brivudine, fialuridine, fiacitabine and netivudine.
Phosphorylation (phosphorylation) of TK associated with herpes zoster and infection
3) Confidence 0.05 Published 1999 Journal Drugs Section Abstract Doc Link 10188760 Disease Relevance 0.88 Pain Relevance 0.08
[s]-1-[3-hydroxy-2-phosphonylmethoxypropyl]cytosine; HPMPC); these agents do not depend on the virus-encoded TK for their phosphorylation but depend on cellular enzymes for conversion to their diphosphoryl derivatives which then inhibit viral DNA synthesis.
Phosphorylation (phosphorylation) of TK
4) Confidence 0.05 Published 1999 Journal Drugs Section Abstract Doc Link 10188760 Disease Relevance 0.77 Pain Relevance 0.07

General Comments

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