INT81127

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Context Info
Confidence 0.25
First Reported 1999
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat) plasma membrane (Gabrd)
Anatomy Link Frequency
neurons 1
Gabrd (Rattus norvegicus)
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 21 100.00 Very High Very High Very High
anticonvulsant 21 99.52 Very High Very High Very High
GABAergic 10 98.08 Very High Very High Very High
antagonist 3 87.04 High High
Glutamate receptor 4 79.04 Quite High
Analgesic 1 65.92 Quite High
sodium channel 11 65.84 Quite High
Lamotrigine 7 63.72 Quite High
carbamazepine 9 62.80 Quite High
antiepileptic Drug 14 61.04 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 22 50.00 Quite Low
Manic Depressive Disorder 71 5.00 Very Low Very Low Very Low
Depression 23 5.00 Very Low Very Low Very Low
Weight Loss 17 5.00 Very Low Very Low Very Low
Obesity 14 5.00 Very Low Very Low Very Low
Affective Disorder 12 5.00 Very Low Very Low Very Low
Psychosis 10 5.00 Very Low Very Low Very Low
Weight Gain 8 5.00 Very Low Very Low Very Low
Convulsion 7 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diazepam (DZP), PB and PGN all enhanced the IGABA by increasing the apparent affinity of the GABAA receptors to GABA.
GABAA Binding (affinity) of GABA associated with gaba
1) Confidence 0.25 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189117 Disease Relevance 0 Pain Relevance 0.28
METHODS: To compare propofol and GABA, their interaction with the GABAA receptor beta subunit and actin were studied in three cellular fractions of cultured rat neurons using Western blot technique.
GABAA receptor Binding (interaction) of GABA in neurons
2) Confidence 0.02 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12631044 Disease Relevance 0 Pain Relevance 0
These effects do not involve an action on the benzodiazepine-binding site on the GABAA receptor and some studies indicate that TPM does not interact with GABA binding sites or benzodiazepine binding sites on GABAA.
GABAA Neg (not) Binding (interact) of GABA associated with gaba
3) Confidence 0.00 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671954 Disease Relevance 0 Pain Relevance 0.69

General Comments

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