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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 94
Total Number 103
Disease Relevance 90.85
Pain Relevance 92.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
neurons 13
dorsal 5
lateral 4
output neurons 4
hypothalamus 3
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 6237 100.00 Very High Very High Very High
Morphine 2767 100.00 Very High Very High Very High
amygdala 2068 100.00 Very High Very High Very High
Rostral ventromedial medulla 1788 100.00 Very High Very High Very High
Periaqueductal grey 430 100.00 Very High Very High Very High
Chronic low back pain 93 100.00 Very High Very High Very High
projection neuron 70 100.00 Very High Very High Very High
antinociception 315 99.96 Very High Very High Very High
gABA 141 99.96 Very High Very High Very High
electroacupuncture 808 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7545 100.00 Very High Very High Very High
Cold Sores 716 100.00 Very High Very High Very High
Low Back Pain 94 100.00 Very High Very High Very High
Knee Osteoarthritis 85 99.60 Very High Very High Very High
Stress 3453 99.48 Very High Very High Very High
Pain 1918 99.04 Very High Very High Very High
Panic Disorder 66 98.92 Very High Very High Very High
Inflammatory Pain 175 98.72 Very High Very High Very High
Hyperalgesia 215 98.16 Very High Very High Very High
Anxiety Disorder 1233 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Complete fMRI data were collected only in eight CBP and five OA patients and only these data were analyzed.
Gene_expression (collected) of CBP associated with chronic low back pain and osteoarthritis
1) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584040 Disease Relevance 2.51 Pain Relevance 2.45
provide evidence for a participation of the PAG in the pathophysiology of PD.

2.

Gene_expression (participation) of PAG associated with panic disorder and urological neuroanatomy
2) Confidence 0.57 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.69 Pain Relevance 0.24
Functional connectivity results (as shown in Table 1 and Figure 2) demonstrated that during genuine EA, there was predominant positive functional connectivity between the PAG and nearby brain structures, including the bilateral PAG and surrounding areas (midbrain tegmentum, substantia nigra, raphe nucleus, hypothalamus, striatum, globus pallidum, left insula, thalamus, hippocampus, brain stem, and cerebellum).
Gene_expression (connectivity) of PAG in raphe nucleus associated with insula, substantia nigra, thalamus, midbrain, hippocampus, urological neuroanatomy, electroacupuncture and raphe
3) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2993660 Disease Relevance 0.46 Pain Relevance 0.58
Functional connectivity results (as shown in Table 1 and Figure 2) demonstrated that during genuine EA, there was predominant positive functional connectivity between the PAG and nearby brain structures, including the bilateral PAG and surrounding areas (midbrain tegmentum, substantia nigra, raphe nucleus, hypothalamus, striatum, globus pallidum, left insula, thalamus, hippocampus, brain stem, and cerebellum).
Gene_expression (was) of PAG in raphe nucleus associated with insula, substantia nigra, thalamus, midbrain, hippocampus, urological neuroanatomy, electroacupuncture and raphe
4) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2993660 Disease Relevance 0.47 Pain Relevance 0.62
Prior to joining the PAG, I had a strong resentment fermenting inside me for a very long time.
Gene_expression (joining) of PAG associated with urological neuroanatomy
5) Confidence 0.55 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2533322 Disease Relevance 0.46 Pain Relevance 0
While we do not know the extent to which the allowance influenced participation, six months after the last PAG meeting most of the groups are still meeting and some have expanded their activities.
Gene_expression (meeting) of PAG associated with urological neuroanatomy
6) Confidence 0.55 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2533322 Disease Relevance 0.53 Pain Relevance 0
Three brief questionnaires were completed by the women during the first and last PAG meetings:
Gene_expression (meetings) of PAG associated with urological neuroanatomy
7) Confidence 0.55 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2533322 Disease Relevance 0.66 Pain Relevance 0.08
PAG-RVM neurons were activated by morphine in females suggests that morphine
Gene_expression (neurons) of PAG-RVM in neurons associated with central grey, morphine and rostral ventromedial medulla
8) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.21 Pain Relevance 2.06
within the PAG of male but not female rats [82] and is
Gene_expression (within) of PAG associated with central grey
9) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.24 Pain Relevance 1.67
PAG-RVM neurons in males were activated by morphine, whereas only 20% were
Gene_expression (neurons) of PAG-RVM in neurons associated with central grey, morphine and rostral ventromedial medulla
10) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.26 Pain Relevance 1.92
morphine action in the PAG were conducted exclusively in males; therefore it
Gene_expression (action) of PAG associated with central grey and morphine
11) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.12 Pain Relevance 1.43
analgesic actions of both systemic and intra-PAG morphine, these early studies
Gene_expression (morphine) of intra-PAG associated with analgesic, central grey and morphine
12) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.92 Pain Relevance 2.31
that the dorsomedial, lateral and ventrolateral PAG heavily project to the RVM
Gene_expression (project) of PAG in lateral associated with central grey and rostral ventromedial medulla
13) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.11 Pain Relevance 1.52
females had significantly more PAG-RVM output neurons across the rostrocaudal
Gene_expression (output neurons) of PAG-RVM in output neurons associated with central grey and rostral ventromedial medulla
14) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.28 Pain Relevance 1.54
and ventrolateral regions of the PAG, an area known to contain a dense distribution
Gene_expression (regions) of PAG associated with central grey
15) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.44 Pain Relevance 1.50
Given that more PAG neurons
Gene_expression (neurons) of PAG in neurons associated with central grey
16) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.22 Pain Relevance 2.09
in the PAG was comparable between the sexes (see
Gene_expression (comparable) of PAG associated with central grey
17) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.99 Pain Relevance 0.82
However, when the analysis was limited to PAG neurons
Gene_expression (neurons) of PAG in neurons associated with central grey
18) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.29 Pain Relevance 1.80
the PAG in males and females, it was suboptimal in producing behaviorally defined
Gene_expression (females) of PAG associated with central grey
19) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.49 Pain Relevance 1.80
To examine the activation of PAG-RVM neurons during
Gene_expression (neurons) of PAG-RVM in neurons associated with central grey and rostral ventromedial medulla
20) Confidence 0.52 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.58 Pain Relevance 2.00

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