INT8145

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Context Info
Confidence 0.74
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.68
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 2
CGB5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 42 99.74 Very High Very High Very High
opioid receptor 28 99.16 Very High Very High Very High
cocaine 7 99.00 Very High Very High Very High
Enkephalin 14 98.96 Very High Very High Very High
Nicotine 7 98.64 Very High Very High Very High
Potency 14 98.32 Very High Very High Very High
antagonist 14 97.80 Very High Very High Very High
Dynorphin 7 93.88 High High
headache 1 90.44 High High
Central nervous system 1 88.72 High High
Disease Link Frequency Relevance Heat
Skin Cancer 16 99.98 Very High Very High Very High
Leiomyosarcoma 3 99.96 Very High Very High Very High
Germinoma 5 99.90 Very High Very High Very High
Cancer 6 99.12 Very High Very High Very High
Seminoma 4 98.72 Very High Very High Very High
Sarcoma 1 94.64 High High
Metrorrhagia 8 93.12 High High
Headache 1 90.44 High High
Central Nervous System Disease 1 88.72 High High
Pain 4 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of hCG release by any of the peptides was totally reversed by opioid antagonists, indicating that the action of peptides is mediated by placental opioid receptors.
Localization (release) of hCG associated with antagonist, opioid receptor and opioid
1) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.90
All peptides stimulated hCG release and their concentration-response curves were bell shaped.
Localization (release) of hCG
2) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.75
Data presented in this manuscript indicate that placental opioid receptors mediate one of the mechanisms regulating hCG release from trophoblast tissue and confirm our earlier results using opioid drugs.
Localization (release) of hCG associated with opioid receptor and opioid
3) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.85
Stimulation of hCG release caused by certain concentrations of nonopioid drugs was not reversed by opioid antagonists, demonstrating that their effect is not mediated by opioid receptors.
Localization (release) of hCG associated with antagonist, opioid receptor and opioid
4) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 1.01
The in vitro effect of three opioid peptides on hCG release from term trophoblast tissue was investigated.
Localization (release) of hCG associated with opioid
5) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.54
Furthermore, the concentration-response curve of isoproterenol was biphasic, suggesting the presence of a mechanism regulating hCG release that is not mediated by placental beta-adrenergic receptors.
Localization (release) of hCG
6) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.94
In order to confirm the specificity of opioid regulation of hCG release, three nonopioid drugs (cocaine, nicotine, and isoproterenol), with binding proteins and receptors known to be present in trophoblast tissue membranes, were also investigated.
Localization (release) of hCG associated with nicotine, opioid and cocaine
7) Confidence 0.74 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.96
Radiation therapy leads to the resolution of his pineal germinoma and normalization of the beta-HCG.
Localization (normalization) of beta-HCG associated with germinoma
8) Confidence 0.65 Published 2009 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 19779380 Disease Relevance 0.89 Pain Relevance 0.13
Beta-HCG is usually increased in germ-cell tumors but few reports in the literature describe beta-HCG-secreting leiomyosarcomas.
Localization (secreting) of beta-HCG associated with leiomyosarcoma and cancer
9) Confidence 0.60 Published 2002 Journal Am. J. Med. Sci. Section Abstract Doc Link 12186103 Disease Relevance 0.70 Pain Relevance 0.07
Secretion of hCG/beta-hCG by squamous cell carcinoma of the lung in a 31-year-old female smoker.
Localization (Secretion) of hCG in lung associated with skin cancer
10) Confidence 0.44 Published 2000 Journal Jpn. J. Clin. Oncol. Section Title Doc Link 10798545 Disease Relevance 0.62 Pain Relevance 0.08
Secretion of hCG/beta-hCG by squamous cell carcinoma of the lung in a 31-year-old female smoker.
Localization (Secretion) of hCG in lung associated with skin cancer
11) Confidence 0.44 Published 2000 Journal Jpn. J. Clin. Oncol. Section Title Doc Link 10798545 Disease Relevance 0.63 Pain Relevance 0.08
We describe a rare case of pulmonary squamous cell carcinoma secreting human chorionic gonadotropin (hCG) and its beta-subunit (beta-hCG) in a young female smoker.
Localization (secreting) of hCG associated with skin cancer
12) Confidence 0.44 Published 2000 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 10798545 Disease Relevance 0.42 Pain Relevance 0.08
We describe a rare case of pulmonary squamous cell carcinoma secreting human chorionic gonadotropin (hCG) and its beta-subunit (beta-hCG) in a young female smoker.
Localization (secreting) of hCG associated with skin cancer
13) Confidence 0.44 Published 2000 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 10798545 Disease Relevance 0.42 Pain Relevance 0.08

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