INT81453

Context Info Confidence 0.50 First Reported 1999 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 18 Total Number 20 Disease Relevance 9.39 Pain Relevance 3.23

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

Anatomy Link Frequency alpha cells 4 liver 2 osteoblast 2 brain 2 A549 2 JUN (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 4 99.68 electroacupuncture 4 99.62 cytokine 46 99.12 addiction 1 99.00 chemokine 9 98.72 opiate 1 98.48 Demyelination 11 98.00 rheumatoid arthritis 96 97.30 Chronic pancreatitis 6 93.88 Potency 2 90.84

Disease Link Frequency Relevance Heat Pancreatic Cancer 11 99.88 Cancer 119 99.84 Osteoporosis 1 99.66 Acquired Immune Deficiency Syndrome Or Hiv Infection 109 99.44 Repression 17 99.16 Glioblastoma 2 98.60 Demyelinating Disease 12 98.00 Leukemia 3 98.00 Frailty 52 97.48 Death 48 97.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion; a) in pancreatic cancer, the expression of c-jun is increased in tumour cells in majority of cases as compared to the control group, b) a c-jun positivity is also found in alpha cells with a pattern not different from control group, but the relation between the alpha cells and c-jun production is unknown, c) c-jun expression does not vary in relation to histological findings.

Neg (not) Positive_regulation (vary) of Gene_expression (expression) of c-jun in alpha cells associated with cancer and pancreatic cancer

1) Confidence 0.50 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.64 Pain Relevance 0.17

In conclusion; a) in pancreatic cancer, the expression of c-jun is increased in tumour cells in majority of cases as compared to the control group, b) a c-jun positivity is also found in alpha cells with a pattern not different from control group, but the relation between the alpha cells and c-jun production is unknown, c) c-jun expression does not vary in relation to histological findings.

Positive_regulation (increased) of Gene_expression (expression) of c-jun in alpha cells associated with cancer and pancreatic cancer

2) Confidence 0.50 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.76 Pain Relevance 0.25

Interestingly, although increased expression of the c-jun transcription factor contributes to NRG1-induced demyelination, its phosphorylation by JNK is not essential to mediate Schwann cell degeneration (Parkinson et al., 2008).

Positive_regulation (increased) of Gene_expression (expression) of c-jun in Schwann cell associated with demyelination

3) Confidence 0.49 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.80 Pain Relevance 0.14

We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor c-Jun, which in turn, induces the expression of MDR1/Pgp170.

Positive_regulation (induces) of Gene_expression (expression) of c-Jun

4) Confidence 0.40 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.07 Pain Relevance 0

AP-1 mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, and bacterial and viral infections, as well as oncogenic stimuli.36 Interestingly, a rat model after portal branch ligation produced atrophy of the deprived lobes (70% of the liver parenchyma), whereas the perfused lobes undergo compensatory regeneration; c-fos and c-jun expression were elevated during the first 2 hours in all the compartments.37 These findings suggest that the cellular and molecular changes that occur early in a regenerating liver are nonspecific, possibly stress-induced cellular responses.

Positive_regulation (elevated) of Gene_expression (expression) of c-jun in liver associated with stress, frailty, viral infection and cytokine

5) Confidence 0.30 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.10 Pain Relevance 0.08

However, an analysis of the differential gene expression shows that the present RA group is generally characterized by an expression profile highly compatible with previous gene expression studies [39], including the overexpression of several transcription factors (for example, FOS, FOSB, JUN, and STAT1 [10-12]), cytokines/chemokines (for example, IL2, IL4, CCL23, and CCL25 [40]), signal transduction molecules (for example, MAPK9, MAP3K2, PTPN7, and AKT2 [41,42]), cell cycle regulators (for example, CDC12, CCNB2, and CCNE2 [43]), and heat shock proteins (DNAJ molecules; [44]; data not shown), indicating that the present RA cohort is representative for RA patients in general.

Positive_regulation (overexpression) of Gene_expression (overexpression) of JUN associated with chemokine, shock, rheumatoid arthritis and cytokine

6) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.15 Pain Relevance 0.57

Thus, the increase in magnitude of JUN expression seen in WTSTS could lead to the induction of FOSL2 and LTBP3 seen in these cells.

Positive_regulation (increase) of Gene_expression (expression) of JUN

7) Confidence 0.22 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.16 Pain Relevance 0

Furthermore, overexpression of c-Jun stimulated TRPC6 expression and CCE amplitude in PASMC.

Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Jun

8) Confidence 0.19 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12529250 Disease Relevance 0 Pain Relevance 0.09

To determine whether AP-1 binding was altered, we transfected AGS cells with an AP-1 luciferase construct and then treated them with H. pylori for up to 6 h.

Positive_regulation (transfected) of Gene_expression (transfected) of AP-1 in AGS

9) Confidence 0.17 Published 2007 Journal Am. J. Gastroenterol. Section Body Doc Link 17617207 Disease Relevance 0.07 Pain Relevance 0

Given that there is a significant increase in JUN expression, perhaps JUN is a major contributing factor to the pro-survival state of the infected cell.

Positive_regulation (increase) of Gene_expression (expression) of JUN

10) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.59 Pain Relevance 0.06

Lipopolysaccharides (LPS) are the major component of the outer membrane of Gram-negative bacteria, and have been shown to induce the expression of JUN [8,9].

Positive_regulation (induce) of Gene_expression (expression) of JUN

11) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.47 Pain Relevance 0.08

Zhang et al. [25] have demonstrated that exposure to excessive fluoride could stimulate the activation and proliferation of osteoblast-like cells with enhanced expression of messenger ribonucleic acid and proteins of c-fos and c-jun.

Positive_regulation (enhanced) of Gene_expression (expression) of c-jun in osteoblast associated with osteoporosis

12) Confidence 0.09 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636628 Disease Relevance 0.74 Pain Relevance 0.03

In different experimental animal models, electroacupuncture was also found to increase brain expression of the c-fos and c-jun genes, as well as the expression of their related protein products (7–9).

Positive_regulation (increase) of Gene_expression (expression) of c-jun in brain associated with electroacupuncture

13) Confidence 0.08 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193541 Disease Relevance 0 Pain Relevance 0.46

-catenin/Tcf complex [68], suggesting that c-Jun functions as an adaptor protein to mediate the association of Dsh with the ?

Positive_regulation (mediate) of Gene_expression (functions) of c-Jun

14) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0

Activation of AP-1 and CRE-dependent gene expression via mu-opioid receptor.

Positive_regulation (Activation) of Gene_expression (expression) of AP-1 associated with opioid receptor

15) Confidence 0.05 Published 2004 Journal J. Neurochem. Section Title Doc Link 15287893 Disease Relevance 0.08 Pain Relevance 0.82

Perineural HIV-1 gp120 is associated with increased ATF3, caspase-3 but not GAP-43 or c-Jun expression in the DRG

Positive_regulation (increased) of Gene_expression (expression) of c-Jun associated with acquired immune deficiency syndrome or hiv infection

16) Confidence 0.04 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.64 Pain Relevance 0.13

In addition, PGE(2) and butaprost increased c-Fos expression and activator protein 1 (AP-1) transcriptional activity, which were abolished by the mitogen-activated protein kinase/Erk kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)-butadiene ethanolate (U0126).

Positive_regulation (increased) of Gene_expression (expression) of activator protein 1

17) Confidence 0.03 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.45 Pain Relevance 0.04

The rank order of trans-repression potencies in A549 lung cells transiently transfected with an AP-1- or NF-kappaB-dependent luciferase gene was fluticasone propionate > budesonide > beclomethasone dipropionate, triamcinolone acetonide, and flunisolide.

Positive_regulation (transfected) of Gene_expression (transfected) of AP-1 in A549 associated with repression

18) Confidence 0.03 Published 2000 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10903220 Disease Relevance 0.59 Pain Relevance 0.21

Increased binding of AP-1 (activator protein-1) activity, observed in an electrophoretic mobility shift assay, was suggested as the molecular mechanism by which GST is overexpressed, in turn conferring resistance to doxorubicin in leukemia [129].

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of activator protein-1 associated with leukemia

19) Confidence 0.03 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.62 Pain Relevance 0.03

In addition, PGE(2) and butaprost increased c-Fos expression and activator protein 1 (AP-1) transcriptional activity, which were abolished by the mitogen-activated protein kinase/Erk kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)-butadiene ethanolate (U0126).

Positive_regulation (increased) of Gene_expression (expression) of AP-1

20) Confidence 0.03 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.45 Pain Relevance 0.06

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