INT81496

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 68
Total Number 71
Disease Relevance 30.04
Pain Relevance 24.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR2) signal transducer activity (CNR2)
Anatomy Link Frequency
brain 4
ovary 3
colon 3
osteoclasts 2
lamina 2
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 1046 100.00 Very High Very High Very High
Cannabinoid 958 100.00 Very High Very High Very High
Cannabinoid receptor 682 100.00 Very High Very High Very High
agonist 375 100.00 Very High Very High Very High
antagonist 342 100.00 Very High Very High Very High
Central nervous system 37 99.96 Very High Very High Very High
fibrosis 24 99.78 Very High Very High Very High
Osteoarthritis 1202 99.52 Very High Very High Very High
Inflammation 787 99.32 Very High Very High Very High
rheumatoid arthritis 1289 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 107 100.00 Very High Very High Very High
Cancer 817 99.98 Very High Very High Very High
Breast Cancer 272 99.98 Very High Very High Very High
Aggression 8 99.90 Very High Very High Very High
Fibrosis 35 99.78 Very High Very High Very High
Frailty 1218 99.52 Very High Very High Very High
INFLAMMATION 759 99.32 Very High Very High Very High
Rheumatoid Arthritis 1289 99.24 Very High Very High Very High
Neuropathic Pain 21 99.04 Very High Very High Very High
Wound Healing 14 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
Spec (examined) Gene_expression (co-expression) of CB2 in osteoclasts associated with cannabinoid
1) Confidence 0.75 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.10 Pain Relevance 0.19
This compound also failed to affect the synthesis and the degradation of the endocannabinoid anandamide, as well as the expression of both CB1 and CB2 cannabinoid receptors in various subpopulations of peripheral lymphocytes.
Gene_expression (expression) of CB2 in lymphocytes associated with endocannabinoid and cannabinoid receptor
2) Confidence 0.75 Published 2009 Journal Neurol. Sci. Section Abstract Doc Link 19768368 Disease Relevance 1.01 Pain Relevance 0.61
Co-expression of TRPV1, CB1/CB2, NAPE-PLD and FAAH was found in both human osteoclast cultures and in native osteoclasts from human bone biopsies.
Gene_expression (Co-expression) of CB2 in osteoclasts
3) Confidence 0.75 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.08 Pain Relevance 0.24
The expression of TRPV1, CB1 and CB2 receptor mRNA and proteins were demonstrated by RT-PCR and polyclonal antibodies, respectively.
Gene_expression (expression) of CB2 receptor
4) Confidence 0.73 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15548432 Disease Relevance 0.09 Pain Relevance 0.44
The findings presented here demonstrate the expression of CB1, CB2 and TRPV1 receptors on cerebromicrovascular endothelial cells (HBEC).
Gene_expression (expression) of CB2 in HBEC
5) Confidence 0.73 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15548432 Disease Relevance 0.10 Pain Relevance 0.37
Therefore, the purpose of this study was to characterize the binding and functional properties of NE at human CB2 receptors stably expressed in Chinese hamster ovary (CHO) cells as well as in HL-60 cells, which express CB2 receptors endogenously.
Gene_expression (express) of CB2 in ovary
6) Confidence 0.72 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0 Pain Relevance 0.36
Therefore, the purpose of this study was to characterize the binding and functional properties of NE at human CB2 receptors stably expressed in Chinese hamster ovary (CHO) cells as well as in HL-60 cells, which express CB2 receptors endogenously.
Gene_expression (expressed) of CB2 in ovary
7) Confidence 0.72 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0 Pain Relevance 0.30
These upregulations initially observed in transfected HL60 cells overexpressing CB2 receptors, also occurred in normal non-transfected HL60 cells.
Gene_expression (overexpressing) of CB2 associated with cannabinoid receptor
8) Confidence 0.69 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.09 Pain Relevance 0.65
The cannabinergic proteins currently being explored, which include the CB1 and CB2 receptors, FAAH and the anandamide transporter, are excellent targets for the development of therapeutically useful drugs for a range of conditions including pain, loss of appetite, immunosuppression, peripheral vascular disease and motor disorders.
Gene_expression (include) of CB2 associated with pain, anorexia and increased venous pressure under development
9) Confidence 0.65 Published 2002 Journal Chem. Phys. Lipids Section Abstract Doc Link 12505686 Disease Relevance 0.28 Pain Relevance 0.30
Understanding of cannabinoid (CB) actions has been remarkably advanced during the last decade, due mainly to the identification of the G-protein-coupled cannabinoid receptors, namely, CB1 receptors that are predominantly found in the brain and CB2 receptors that are exclusively found in peripheral tissues.
Gene_expression (found) of CB2 in brain associated with cannabinoid receptor and cannabinoid
10) Confidence 0.65 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11138722 Disease Relevance 0.07 Pain Relevance 0.66
In fact, PEA does not bind to CB1 and CB2 receptors transfected into host cells, but might be a ligand for a putative CBn receptor present in the RBL-2H3 cell line.
Gene_expression (transfected) of CB2 in RBL-2H3
11) Confidence 0.65 Published 1999 Journal Curr. Med. Chem. Section Abstract Doc Link 10469890 Disease Relevance 0.10 Pain Relevance 0.36
Importantly, over-expression of human recombinant TRPV1 in HEK-293 cells was not accompanied by any significant change in the expression of cannabinoid CB1 or CB2 receptors or of FAAH, nor of endogenous AEA levels, as compared to wild-type HEK-293 cells.
Gene_expression (expression) of CB2 associated with cannabinoid
12) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858646 Disease Relevance 0 Pain Relevance 0.21
Therefore, the purpose of this study was to characterize the binding and functional properties of NE at human CB2 receptors stably expressed in Chinese hamster ovary (CHO) cells as well as in HL-60 cells, which express CB2 receptors endogenously.
Gene_expression (express) of CB2 in ovary
13) Confidence 0.63 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0 Pain Relevance 0.36
Our data are consistent with previous studies on the expression of CB1 and CB2 receptors in human and rodent colon.[20], [21], [36], [37] A novelty of our study is the finding of CB1 staining in the goblet cells.
Gene_expression (expression) of CB2 in colon
14) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.19 Pain Relevance 0.12
Recently, CB2 expression was observed in the enteric nervous system in rodent and human ileum[19], [22], and in the rat ileum containing longitudinal muscle and myenteric plexus.[38] Taking together these results point to a differential role of cannabinoid CB1 and CB2 receptors in human colonic tissue.
Gene_expression (expression) of CB2 in ileum associated with cannabinoid
15) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.14 Pain Relevance 0.08
Using the recently developed methodology of nucleic acid microarrays spotted with specific cDNAs probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand CP-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (IL-8) and the beta-chemokine monocyte chemotactic protein-1 (MCP-1), in the promyelocytic cell line HL60 transfected with peripheral cannabinoid receptors (CB2).
Gene_expression (transfected) of CB2 in monocyte associated with chemokine, cannabinoid receptor and cannabinoid
16) Confidence 0.60 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.05 Pain Relevance 0.45
In fact, CB2R expression in activated cells displayed a ?
Gene_expression (expression) of CB2R
17) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.07
In order to substantiate this concept, the expression of CB1R and CB2R was evaluated on cell surface by means of cytometric analysis and confocal microscopy.
Gene_expression (expression) of CB2R
18) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.13
In the attempt to shed some light on such immunomodulatory activity of AEA, we first collected evidence for the alteration of the expression of CB1R and CB2R, as a result of cell activation.
Gene_expression (expression) of CB2R
19) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.08 Pain Relevance 0.14
To date there is evidence showing that classical antigenic stimuli, such as LSP or anti-CD3, can modulate both CB1R and CB2R expression, however there are discrepancies in the literature especially because of the different experimental models used, spanning from Jurkat cells to mouse splenocytes [8].
Gene_expression (expression) of CB2R
20) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.06 Pain Relevance 0.06

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