INT81574

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 10.85
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (SIL1) protein folding (SIL1) endoplasmic reticulum (SIL1)
Anatomy Link Frequency
epithelial cells 1
A549 1
SIL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 114 98.96 Very High Very High Very High
imagery 3 95.96 Very High Very High Very High
backache 1 87.72 High High
Pain 6 50.00 Quite Low
spastic colon 2 33.08 Quite Low
Nicotine 144 5.00 Very Low Very Low Very Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
COX-2 inhibitor 16 5.00 Very Low Very Low Very Low
cINOD 16 5.00 Very Low Very Low Very Low
addiction 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 40 100.00 Very High Very High Very High
Nicotine Addiction 484 99.84 Very High Very High Very High
Non-small-cell Lung Cancer 144 99.68 Very High Very High Very High
Cancer 641 99.18 Very High Very High Very High
Stress 1082 98.98 Very High Very High Very High
INFLAMMATION 153 98.96 Very High Very High Very High
Periodontitis 19 98.06 Very High Very High Very High
Apoptosis 128 96.84 Very High Very High Very High
Disease 119 94.48 High High
Malignant Neoplastic Disease 320 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laboratory studies showed increased serum bone-specific alkaline phosphatase (BAP) and urinary type I collagen crosslinked N-telopeptide (NTx).
Positive_regulation (increased) of BAP
1) Confidence 0.67 Published 2003 Journal J Orthop Sci Section Abstract Doc Link 14557944 Disease Relevance 0.24 Pain Relevance 0.23
Although our data support the conclusion that modulators of the UPR pathway are chronically impacted in this tumor type, aside from a modestly significant increase in BiP in the NSCLC diagnostic group with increasing age (p = 0.0187), we found no obvious correlation with any histopathological criteria such as gender, pathologic stage, histological type, or TMN-status and the increased expression of eIF2?
Positive_regulation (increase) of BiP associated with non-small-cell lung cancer and cancer
2) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.36 Pain Relevance 0
Alternatively, since there are significant differences between our exposure parameters and those detailed in these two recent reports, a more likely explanation may be that the brief CS treatment protocol (20 min followed by washout and addition of fresh medium) used in our experiments resulted in an abbreviated UPR response that fails to trigger BiP upregulation.
Positive_regulation (upregulation) of BiP
3) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.09 Pain Relevance 0
In one recent publication, Hengstermann and Muller [31] saw a modest increase in BiP RNA levels in mouse cells after 4 h continuous treatment with PBS into which CS was previously bubbled [31].
Positive_regulation (increase) of BiP RNA
4) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.35 Pain Relevance 0
We observed that both of these much longer exposure procedures did result in the upregulation of BiP, although not to the degree seen with the more potent ER-stress inducer thapsigargin (Figure 7).
Positive_regulation (upregulation) of BiP associated with stress
5) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0
A second report by Kelsen et al, [30] observed increased BiP protein levels in virally transformed human bronchial epithelial cells after 24 h continuous treatment with 15% cigarette smoke extract.
Positive_regulation (increased) of BiP protein in epithelial cells
6) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.32 Pain Relevance 0
For example, when ER stress becomes chronic, one pro-survival mechanism is to upregulate the master regulator, BiP, which allows the cell to endure an increased level of unfolded proteins and forestall apoptosis [63,64].
Positive_regulation (upregulate) of BiP associated with stress and apoptosis
7) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0
Control cells treated with thapsigargin show strong induction of BiP by 24 h.
Positive_regulation (induction) of BiP
8) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.20 Pain Relevance 0
The only correlation found in these data was a statistically significant increase in BiP in the NSCLC diagnostic group with increasing age (p = 0.0187).
Positive_regulation (increase) of BiP associated with non-small-cell lung cancer
9) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.12 Pain Relevance 0
We further found a significant increase in expression of BiP in a majority of cases of NSCLCs (87.5%; p = < 0.0001) and MCs (100%; p = < 0.0001), but not in SCLCs.
Positive_regulation (increase) of BiP
10) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.99 Pain Relevance 0
Consequently, these data, while agreeing with previous reports showing that BiP expression is induced by CS [30,31], clearly show that BiP induction can be modulated depending on level and duration of stress-inducing conditions.
Positive_regulation (induction) of BiP associated with stress
11) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.48 Pain Relevance 0
Since BiP induction is a relatively late event in the UPR signaling cascade, differing stress-inducing exposure conditions can lead to short term perturbations without durable long-term changes [12].
Positive_regulation (induction) of BiP associated with stress
12) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.10 Pain Relevance 0
However, when the array data was assessed to determine changes in the levels of three genes whose transcription is dependent on activated ATF6 (i.e., BiP, XBP1, and grp94) [60], we found that both XBP1 and BiP transcript levels are elevated in response to CS treatment (Figure 5).
Positive_regulation (elevated) of BiP
13) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.21 Pain Relevance 0
For example, several UPR proteins, including BiP and calreticulin, were found to be up-regulated in smokers.
Positive_regulation (up) of BiP associated with nicotine addiction
14) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.43 Pain Relevance 0
For example, several UPR proteins, including BiP and calreticulin, were found to be up-regulated in smokers.
Positive_regulation (regulated) of BiP associated with nicotine addiction
15) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.43 Pain Relevance 0
M thapsigargin continuously for 72 h, BiP expression is still only seen after 24 hours post-treatment, indicating that BiP induction is a much later consequence of ER stress than is eIF2?
Positive_regulation (induction) of BiP associated with stress
16) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
In contrast to these studies, our results show that when A549 cells (Figure 6, Panel A) or NHBE cells (data not shown) were briefly exposed to freshly generated whole CS for 20 min, Western blot analysis showed no increase of BiP protein levels up to 72 h post-exposure.
Neg (no) Positive_regulation (increase) of BiP protein in A549
17) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.26 Pain Relevance 0
The pattern of increased BAP and decreased OC has been reported in patients with osteolytic bone metastases.
Positive_regulation (increased) of BAP
18) Confidence 0.10 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.06 Pain Relevance 0
Levels of BAP were increased (p<0.05) over baseline on Days 4, 5, and 6, while those of OC decreased on Days 4, 5, and 6 (p<0.05).
Positive_regulation (increased) of BAP
19) Confidence 0.10 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.07 Pain Relevance 0
Uric acid (UA) is a major antioxidant, but, like most molecules of this category,68 it can also induce opposite effects if concentrations are sufficiently high.69 There are likely to be concentration thresholds delineating positive from negative effects of such substances; acute and even relatively high UA levels protect against oxidative stress70, but chronically elevated UA levels are linked to MSs, reduced adiponectin and elevated E-selectin, in parallel with positive effects such as reduced nitrotyrosine and increased total antioxidant capacity.71 Thus, high UA levels could be a compensatory mechanism that counteracts the oxidative stress related to metabolic or vascular disturbances.72
Positive_regulation (elevated) of MSs associated with stress and syndrome
20) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.57 Pain Relevance 0

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