INT81641

Context Info Confidence 0.72 First Reported 1998 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 23 Total Number 24 Disease Relevance 14.93 Pain Relevance 1.97

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1) protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)

Anatomy Link Frequency colon 2 endothelial cells 2 plasma 1 hair follicle 1 small intestine 1 Ctnnb1 (Mus musculus) Ctnnb1 - S33A (1)

Pain Link Frequency Relevance Heat COX2 9 99.68 metalloproteinase 2 99.64 cINOD 34 99.40 Spinal cord 40 98.96 antagonist 4 98.00 Central nervous system 12 92.44 Inflammation 65 89.92 cytokine 21 74.08 Neuritis 1 41.52 COX-2 inhibitor 1 25.00

Disease Link Frequency Relevance Heat Cancer 367 100.00 Adhesions 52 100.00 Alagille Syndrome 110 99.86 Targeted Disruption 168 99.84 Intestinal Cancer 46 99.84 Chondrosarcoma 4 99.56 Colon Cancer 42 99.32 Adenoma 14 99.26 Chordoma 131 98.52 Apoptosis 101 97.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present investigation, it was examined with RT-PCR whether expression of beta-catenin, a downstream gene of Wnt in its signal transduction pathway, is regulated.

Spec (whether) Gene_expression (expression) of beta-catenin

1) Confidence 0.72 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367680 Disease Relevance 0.07 Pain Relevance 0.05

The aim of this study was to determine if NSAID-induced regression of intestinal adenomas might be associated with changes in beta-catenin or Bcl-2 expression.

Gene_expression (expression) of beta-catenin associated with adenoma and cinod

2) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.96 Pain Relevance 0.24

Cytoplasmic and nuclear beta-catenin are overexpressed in many of these lesions and Bcl-2, which inhibits apoptosis, may also be elevated during the course of intestinal tumorigenesis.

Gene_expression (overexpressed) of beta-catenin associated with apoptosis

3) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.73 Pain Relevance 0.25

Intestinal tumors from Min/+ mice were harvested after treatment with sulindac for 2, 4 or 20 days and evaluated for expression of beta-catenin and Bcl-2 using immunohistochemistry.

Gene_expression (expression) of beta-catenin associated with intestinal cancer

4) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.95 Pain Relevance 0.22

Colonic tumors expressed higher levels of Bcl-2 than those from the small intestine and did not show any significant changes in either Bcl-2 or beta-catenin expression after treatment.

Gene_expression (expression) of beta-catenin in small intestine associated with cancer

5) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.67 Pain Relevance 0.16

Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice.

Gene_expression (expression) of beta-catenin associated with intestinal cancer and cox2

6) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Title Doc Link 10223192 Disease Relevance 0.80 Pain Relevance 0.31

Results suggest that modulation of aberrant beta-catenin expression occurs during NSAID-induced regression of intestinal adenomas and that Bcl-2 may confer resistance to these effects.

Gene_expression (expression) of beta-catenin associated with adenoma and cinod

7) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.74 Pain Relevance 0.17

-catenin expressed from retained intact CTNNB1, which contributes to the promotion of the total Wnt/?

Gene_expression (expressed) of CTNNB1

8) Confidence 0.68 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.60 Pain Relevance 0

On the other hand, AGS cells possess mutation in CTNNB1 close to the phosphorylation site of GSK3?

Gene_expression (possess) of CTNNB1 in AGS associated with alagille syndrome

9) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.54 Pain Relevance 0

-catenin gene (CTNNB1) at codon 34 (Caca et al, 1999; Supplementary Figure 2), whereas CTNNB1 is amplified in Kato-III cells (Suriano et al, 2005).

Gene_expression (amplified) of CTNNB1

10) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.98 Pain Relevance 0

-catenin accumulated cells after the transient transfection of mutant CTNNB1 (S33A) expression vector (Figure 3C).

Gene_expression (expression) of CTNNB1 (S33A)

11) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.32 Pain Relevance 0

-catenin gene (CTNNB1) at codon 34 (Caca et al, 1999; Supplementary Figure 2), whereas CTNNB1 is amplified in Kato-III cells (Suriano et al, 2005).

Gene_expression (amplified) of CTNNB1

12) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.02 Pain Relevance 0

Mutations in exon 3 of CTNNB1 result in stabilization of a protein that resists degradation, leading to nuclear accumulation of ?

Gene_expression (exon) of CTNNB1

13) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.99 Pain Relevance 0

It has been shown that microvascular endothelial cells, isolated from murine spinal cord, morphologically similar to BBB endothelial cells, express reduced amounts of several prominent BBB proteins such as tight junction-associated proteins ZO-1 and occluding, adherens junction-associated proteins beta-catenin and VE-cadherin, and the efflux transporter P-glycoprotein [50].

Gene_expression (express) of beta-catenin in endothelial cells associated with spinal cord

14) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.27 Pain Relevance 0.12

Myc causes depletion of BrdU from LRCs in the IFE, but unlike conditional expression of either TERT or beta-catenin, Myc has not been reported to initiate a new anagen cycle [53].

Gene_expression (expression) of beta-catenin

15) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.11 Pain Relevance 0

Expression of a more active beta-catenin variant in skin also promoted anagen, but in addition caused the formation of new hair follicles and ultimately hair follicle tumors [46,47].

Gene_expression (Expression) of beta-catenin in hair follicle associated with cancer

16) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0

This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.

Gene_expression (deletion) of beta-catenin in colon associated with colon cancer

17) Confidence 0.14 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.16 Pain Relevance 0

This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.

Gene_expression (overexpression) of beta-catenin in colon associated with colon cancer

18) Confidence 0.14 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0

The striking similarities between their gene expression programs and the fact that TERT expression phenocopies beta-catenin in skin suggest the possibility that TERT impinges upon the Wnt pathway (see Text S1 and Table S10 for additional details).

Gene_expression (expression) of beta-catenin in skin

19) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0

ligands omega-6 fatty acids and ciglitazone down-regulated (1-2-fold) beta-catenin and c-myc expression and the selective PPAR?

Gene_expression (expression) of beta-catenin

20) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

This test has worked.