INT81664

Context Info Confidence 0.68 First Reported 1999 Last Reported 2006 Negated 0 Speculated 0 Reported most in Title Documents 12 Total Number 12 Disease Relevance 2.51 Pain Relevance 9.75

extracellular region (Pnoc)

Anatomy Link Frequency astrocytes 8 brain 4 heart 4 plasma 2 spinal cord 2 Pnoc (Rattus norvegicus)

Pain Link Frequency Relevance Heat orphanin 66 100.00 Morphine 40 100.00 narcan 12 100.00 Dynorphin 9 100.00 Enkephalin 7 100.00 anesthesia 2 100.00 Inflammation 7 99.98 IPN 1 99.78 vanilloid receptor subtype 1 4 99.04 Dorsal horn 1 98.80

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 6 100.00 INFLAMMATION 4 99.98 Hepatocellular Cancer 2 99.84 Inflammatory Pain 1 99.78 Nociception 2 94.16 Pain 3 93.44 Cognitive Disorder 1 92.72 Leukemia 2 92.16 Hepatolenticular Degeneration 1 89.16 Urological Neuroanatomy 3 83.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results suggest that peripheral inflammation induces the production of nociceptin in a sub-population of VR1-positive primary sensory neurons and support the idea that nociceptin produced there is involved in the regulation of nociceptive processing.

Positive_regulation (induces) of Gene_expression (production) of nociceptin in primary sensory neurons associated with nociception, vanilloid receptor subtype 1, inflammation and orphanin

1) Confidence 0.68 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11448514 Disease Relevance 0.49 Pain Relevance 0.75

Chronic inflammatory pain causes an increase in the expression of nociceptin and the ORL1 receptor in the dorsal horn of rat spinal cord, thus indicating an involvement of the endogenous nociceptin/ORL1 system in mechanisms of pathological pain.

Positive_regulation (increase) of Gene_expression (expression) of nociceptin in spinal cord associated with pain, orphanin, ipn, dorsal horn and spinal cord

2) Confidence 0.65 Published 2004 Journal Anaesthesist Section Abstract Doc Link 15127152 Disease Relevance 0.54 Pain Relevance 1.09

Microinjection of nociceptin (Orphanin FQ) into nucleus tractus solitarii elevates blood pressure and heart rate in both anesthetized and conscious rats.

Positive_regulation (elevates) of Gene_expression (Microinjection) of nociceptin in heart associated with anesthesia and orphanin

3) Confidence 0.50 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10871320 Disease Relevance 0.36 Pain Relevance 0.66

Ir levels of dynorphin A, dynorphin B, Leu-enkephalin-Arg(6), Met-enkephalin-Arg(6)Phe(7) and nociceptin/orphanin FQ were measured in the pituitary gland and in 10 areas of the brain during the diestrus, proestrus and estrus phase.

Positive_regulation (measured) of Gene_expression (levels) of nociceptin in brain associated with dynorphin, orphanin and enkephalin

4) Confidence 0.49 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16540166 Disease Relevance 0 Pain Relevance 0.92

Microinjections of nociceptin, an endogenous ligand for the nociceptin receptor, into the relatively rostral NTS produced dose-related (0.04, 0.2, and 1 nmol) increases in blood pressure and heart rate.

Positive_regulation (increases) of Gene_expression (produced) of nociceptin in heart associated with pressure and volume under development and orphanin

5) Confidence 0.41 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857705 Disease Relevance 0.25 Pain Relevance 0.81

Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats.

Positive_regulation (Accelerated) of Gene_expression (production) of orphanin FQ in brain associated with orphanin and morphine

6) Confidence 0.40 Published 1999 Journal Brain Res. Section Title Doc Link 10224316 Disease Relevance 0.24 Pain Relevance 1.23

Nociceptin mRNA expression was increased by treatment with 20 or 80 ng/ml LIF for 24 h, but choline acetyl transferase, glutamic acid decarboxylase, enkephalin, dynorphin, substance P, somatostatin and galanin mRNA expression were not altered by LIF.

Positive_regulation (increased) of Gene_expression (expression) of Nociceptin mRNA associated with dynorphin, orphanin, somatostatin, enkephalin and substance p

7) Confidence 0.23 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11585557 Disease Relevance 0.17 Pain Relevance 0.46

Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.

Positive_regulation (overexpression) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine

8) Confidence 0.05 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82

Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.

Positive_regulation (overexpression) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine

9) Confidence 0.04 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82

Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.

Positive_regulation (overexpression) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine

10) Confidence 0.04 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82

Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.

Positive_regulation (Morphine-induced) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine

11) Confidence 0.04 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82

Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma.

Positive_regulation (Increased) of Gene_expression (levels) of nociceptin in plasma associated with orphanin and hepatocellular cancer

12) Confidence 0.03 Published 2004 Journal World J. Gastroenterol. Section Title Doc Link 14695766 Disease Relevance 0.46 Pain Relevance 0.52

General Comments

This test has worked.