INT81734

Context Info Confidence 0.43 First Reported 1999 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 7.77 Pain Relevance 3.06

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc) cytoplasm (Arc)

Anatomy Link Frequency dentate gyrus 6 ARC 2 brain 2 melanocyte 2 nucleus 2 Arc (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 4 100.00 Dorsal horn 1 100.00 Hippocampus 39 99.68 Dynorphin 6 99.24 amygdala 10 99.12 withdrawal 34 97.94 primary afferent fibers 2 97.08 Inflammation 18 96.24 depression 9 94.96 c fibre 4 94.80

Disease Link Frequency Relevance Heat Aids-related Complex 291 100.00 Diabetes Mellitus 18 99.82 Cognitive Disorder 64 96.52 Encephalitis 6 96.24 Depression 9 94.96 Targeted Disruption 17 94.08 Disease 87 93.88 Retrograde Degeneration 2 90.12 Body Weight 10 88.48 Nociception 6 87.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Dysregulation of BDNF synthesis and Arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and Alzheimer's disease.

Regulation (Dysregulation) of Gene_expression (synthesis) of Arc in dentate gyrus associated with cognitive disorder, depression, aids-related complex and disease

1) Confidence 0.43 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.89 Pain Relevance 0.11

Double-labelling revealed that N/OFQ was present in some neurones located in the ventrolateral part of the Arc producing pro-opiomelanocortin, as shown by the presence of the anorexigenic peptides alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript and, occasionally, in single neurones of the ventrolateral Arc producing orexigenic agouti-related peptide, but not neuropeptide Y.

Regulation (ventrolateral) of Gene_expression (part) of Arc in melanocyte associated with aids-related complex, neuropeptide and cocaine

2) Confidence 0.43 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20025627 Disease Relevance 0.35 Pain Relevance 0.45

expression of Arc, Narp, and Zif268 in the dentate gyrus after training rats in

Regulation (dentate gyrus) of Gene_expression (expression) of Arc in dentate gyrus associated with aids-related complex

3) Confidence 0.42 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.49 Pain Relevance 0.06

in C10, C60, L10, and L60 animals when compared with caged control (CC) animals (Figure 2, P > .05), indicating that Arc expression in the dentate

Regulation (indicating) of Gene_expression (expression) of Arc associated with aids-related complex

4) Confidence 0.42 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.70 Pain Relevance 0

blades of the dentate gyrus, whereas Arc and Narp expression are selectively

Regulation (blades) of Gene_expression (expression) of Arc in dentate gyrus associated with aids-related complex

5) Confidence 0.42 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.82 Pain Relevance 0

These results confirm the role of dynamic changes in Arc expression in neuronal plasticity and demonstrate the ability of memantine to reinstate the dynamic balance of cellular processes that were disturbed by chronic brain inflammation. ?

Regulation (changes) of Gene_expression (expression) of Arc in brain associated with inflammation, aids-related complex and encephalitis

6) Confidence 0.35 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.89 Pain Relevance 0.13

Therefore, our findings reveal that actin rearrangements in the amygdala and the DH are required for the acquisition and consolidation of the aversive memories of drug withdrawal and that the beta-noradrenergic system within the amygdala modulates aversive memory consolidation by regulating actin rearrangements but not Arc protein expression in the DH, which is distinct from its role in modulation of inhibitory avoidance memory.

Neg (not) Regulation (regulating) of Gene_expression (expression) of Arc protein in amygdala associated with aids-related complex, hippocampus, withdrawal and amygdala

7) Confidence 0.25 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19793983 Disease Relevance 0.17 Pain Relevance 1.31

Diabetes did not alter proenkephalin (proEnk) expression in the Arc or pituitary, nor dynorphin A1-17 or beta-endorphin in paraventricular nucleus (PVN). alpha-Melanocyte-stimulating hormone (alpha-MSH) peptide levels were decreased in the PVN and normalized following insulin treatment.

Neg (nor) Regulation (alter) of Gene_expression (expression) of Arc in nucleus associated with dynorphin, aids-related complex and diabetes mellitus

8) Confidence 0.24 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233022 Disease Relevance 1.37 Pain Relevance 0.16

mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.

Neg (not) Regulation (affected) of Gene_expression (expressed) of ARC associated with aids-related complex

9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.79 Pain Relevance 0

In rats chronically infused into the 4th ventricle for 28 days with LPS (via osmotic minipump), there was a region-selective microglia activation, impaired hippocampal-depen-dent memory and altered behaviorally-induced expression of the immediate early gene Arc [234].

Regulation (altered) of Gene_expression (expression) of Arc in microglia associated with aids-related complex

10) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.78 Pain Relevance 0.15

Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers.

Regulation (modulated) of Gene_expression (expression) of Arc in spinal cord dorsal horn associated with aids-related complex, primary afferent fibers, dorsal horn and spinal cord

11) Confidence 0.15 Published 2008 Journal Neuroscience Section Title Doc Link 18555615 Disease Relevance 0.31 Pain Relevance 0.66

Together, the results suggest that short-term alterations in circulating E(2) levels, such as those occurring during the menstrual cycle, may have little effect on the ARC-ME expression of KNDy and associated receptors.

Neg (little) Regulation (effect) of Gene_expression (expression) of ARC-ME in ARC associated with aids-related complex

12) Confidence 0.00 Published 2010 Journal Endocrinology Section Abstract Doc Link 20519367 Disease Relevance 0.22 Pain Relevance 0.03

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