INT81775

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 9.12
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) cytoplasm (F3)
Anatomy Link Frequency
nucleus 3
leukocyte 2
plasma 1
endothelial cells 1
monocytes 1
F3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 93.44 High High
Angina 11 91.96 High High
cytokine 17 87.00 High High
agonist 38 78.80 Quite High
bradykinin 2 71.12 Quite High
imagery 36 57.96 Quite High
palliative 6 57.32 Quite High
anesthesia 6 49.56 Quite Low
Bioavailability 2 28.00 Quite Low
Bile 2 26.44 Quite Low
Disease Link Frequency Relevance Heat
Cancer 836 100.00 Very High Very High Very High
Stress 30 99.00 Very High Very High Very High
Disorder Of Lipid Metabolism 274 98.16 Very High Very High Very High
Carcinoma 144 97.88 Very High Very High Very High
Adhesions 36 96.68 Very High Very High Very High
Hemolytic Uremic Syndrome 164 96.36 Very High Very High Very High
INFLAMMATION 51 93.44 High High
Cv General 3 Under Development 11 91.96 High High
Breast Cancer 18 90.48 High High
Ovarian Cancer 30 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As F3 was shown to be internalized into the nucleus of tumor cells and therefore may be an appropriate carrier for ?
Localization (internalized) of F3 in nucleus associated with cancer
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.85 Pain Relevance 0
F3 is a tumor homing peptide which is internalized into the nucleus of tumor cells upon binding to nucleolin on the cell surface.
Localization (internalized) of F3 in nucleus associated with cancer
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682652 Disease Relevance 1.36 Pain Relevance 0
It was reported recently by Porkka et al. reported [14] that F3 is internalized into the nucleus of tumor cells and tumor endothelial cells in vitro and in vivo.
Localization (internalized) of F3 in endothelial cells associated with cancer
3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.65 Pain Relevance 0.03
In contrast, only small amounts of radioactivity were detected in non-target organs except for the kidneys were 213Bi-DTPA-[F3]2 is present presumably due to secretion of the peptide.
Localization (secretion) of F3
4) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 1.15 Pain Relevance 0
We therefore asked whether also 213Bi-DTPA-[F3]2 would also be internalized into the nucleus of tumor cells.
Localization (internalized) of F3 in nucleus associated with cancer
5) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.72 Pain Relevance 0.03
As biodistribution studies revealed that 213Bi-DTPA-[F3]2 is excreted via the kidneys but does not accumulate in other organs, primarily renal side effects are to be expected.
Localization (excreted) of F3
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.97 Pain Relevance 0.06
In contrast to atherogenic lipoproteins, like LDL and very low-density lipoprotein (VLDL), which stimulate both the secretion of tissue factor (TF) and the activation of extrinsic tenase, HDL per se does not stimulate the secretion of TF from endothelial cells or monocytes (Kaneko et al 1994).
Localization (secretion) of tissue factor in monocytes associated with disorder of lipid metabolism
7) Confidence 0.17 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.15 Pain Relevance 0
Modulation of hemostasis includes the release of plasminogen activator, tissue factor inhibitor, von Willebrand factor, NO, prostacyclin, TXA2, plasminogen-activator inhibitor-1 (PAI-1), and fibrinogen.
Localization (release) of tissue factor
8) Confidence 0.16 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.90 Pain Relevance 0.12
The interaction between Stx or LPS and blood cells induced platelet-leukocyte aggregate formation and tissue factor (TF) release, as detected by flow cytometry in whole blood.
Localization (release) of tissue factor in leukocyte
9) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2735777 Disease Relevance 0.30 Pain Relevance 0
Stx 2 and EHEC-LPS induce release of functional tissue factor into plasma under shear stress
Localization (release) of tissue factor in plasma associated with stress
10) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.19 Pain Relevance 0.11
Aggregates formed between leukocytes and platelets in the circulation lead to release of tissue factor (TF)–bearing microparticles contributing to a prothrombotic state.
Localization (release) of tissue factor in platelets
11) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2735777 Disease Relevance 0.27 Pain Relevance 0
Aggregates formed between leukocytes and platelets in the circulation lead to release of tissue factor (TF)–bearing microparticles contributing to a prothrombotic state.
Localization (release) of tissue factor in leukocytes
12) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2735777 Disease Relevance 0.27 Pain Relevance 0
Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration.
Localization (release) of Tissue factor
13) Confidence 0.03 Published 1999 Journal Thromb. Haemost. Section Title Doc Link 10235445 Disease Relevance 0.34 Pain Relevance 0.39

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