INT81787

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 1999
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 0
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) extracellular space (AGRP) extracellular region (AGRP)
Golgi apparatus (AGRP) plasma membrane (MC1R) signal transducer activity (MC1R)
AGRP (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 98.04 Very High Very High Very High
melanocortin 1 receptor 6 89.68 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although previous studies have shown that AGRP binds three of the five known subtypes of melanocortin receptor, the receptor domains participating in binding and the molecular interactions involved are presently unknown.
AGRP Binding (binds) of melanocortin receptor
1) Confidence 0.53 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.12
Contribution of melanocortin receptor exoloops to Agouti-related protein binding.
Agouti-related protein Binding (binding) of melanocortin receptor
2) Confidence 0.39 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.13
Conversely, the exchange of exoloops 2 and 3 of the MC1R with the homologous exoloops of the MC4R was found to confer AGRP binding and inhibitory activity to the basic structure of the MC1R.
AGRP Binding (binding) of MC1R
3) Confidence 0.36 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.10
Conversely, the exchange of exoloops 2 and 3 of the MC1R with the homologous exoloops of the MC4R was found to confer AGRP binding and inhibitory activity to the basic structure of the MC1R.
AGRP Binding (binding) of MC1R
4) Confidence 0.36 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.10
Substitutions of the extracytoplasmic NH2 terminus and the first extracytoplasmic loop (exoloop) of the MC4R with homologous domains of the MC1R had no effect on AGRP (87-132) binding affinity or inhibitory activity (the ability to inhibit melanocortin-stimulated cAMP generation).
AGRP Neg (no) Binding (affinity) of MC1R
5) Confidence 0.34 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.12
Substitutions of the extracytoplasmic NH2 terminus and the first extracytoplasmic loop (exoloop) of the MC4R with homologous domains of the MC1R had no effect on AGRP (87-132) binding affinity or inhibitory activity (the ability to inhibit melanocortin-stimulated cAMP generation).
AGRP Neg (no) Binding (affinity) of MC1R
6) Confidence 0.34 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.12

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