INT81832

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRA2C) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C)
cell-cell signaling (ADRA2C) cytoplasm (ADRA2C) signal transducer activity (ADRA2C)
Anatomy Link Frequency
platelet 3
ADRA2C (Homo sapiens)
CRYGS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
Clonidine 4 97.24 Very High Very High Very High
antagonist 4 95.36 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented indicate that enhancement of [35S]GTPgammaS binding by alpha2-AR in human platelet membranes provides a simple functional measure for receptor activation and can be used for determination of potencies and efficacies of ligands at the alpha2-AR.
alpha2-AR Binding (binding) of GTPgammaS in platelet
1) Confidence 0.06 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.20
The data presented indicate that enhancement of [35S]GTPgammaS binding by alpha2-AR in human platelet membranes provides a simple functional measure for receptor activation and can be used for determination of potencies and efficacies of ligands at the alpha2-AR.
alpha2-AR Binding (binding) of GTPgammaS in platelet
2) Confidence 0.06 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.20
Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline (UK 14304), increased the binding of [35S]GTPgammaS up to approximately 1.8 fold, with half-maximal increase at 60 nM and was competitively inhibited by the alpha2-AR antagonist Rauwolscine.
alpha2-AR Binding (binding) of GTPgammaS associated with antagonist and agonist
3) Confidence 0.05 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.14
Alpha2-adrenoceptor (alpha2-AR)-regulated binding of the labelled GTP analog, guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS), to guanine-nucleotide-binding proteins (G proteins) was studied in human platelet membranes.
alpha2-AR Binding (binding) of GTPgammaS in platelet
4) Confidence 0.05 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.12

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