INT81976

Context Info Confidence 0.02 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.77

plasma membrane (GNA15, OPRL1) signal transducer activity (GNA15, OPRL1) signal transduction (GNA15) GTPase activity (GNA15)

GNA15 (Homo sapiens) OPRL1 (Homo sapiens)

Pain Link Frequency Relevance Heat orphanin 2 100.00 Kappa opioid receptor 2 99.66 opioid receptor 4 97.08 imagery 4 86.08 Opioid 2 79.92 agonist 2 78.40

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We show that the mu, delta, and kappa opioid receptors and the related nociceptin receptor, ORL1, each couple to Galphaqi5, Galphaqo5, and Galpha16 (Galphaqi5 and Galphaqo5 refer to Galphaq proteins containing the five carboxyl-terminal amino acids from Galphai and Galphao, respectively) and that different receptor/G protein combinations show different levels of maximal activation.

Galpha16 Binding (couple) of ORL1 associated with orphanin and kappa opioid receptor

1) Confidence 0.02 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10334841 Disease Relevance 0 Pain Relevance 0.38

We show that the mu, delta, and kappa opioid receptors and the related nociceptin receptor, ORL1, each couple to Galphaqi5, Galphaqo5, and Galpha16 (Galphaqi5 and Galphaqo5 refer to Galphaq proteins containing the five carboxyl-terminal amino acids from Galphai and Galphao, respectively) and that different receptor/G protein combinations show different levels of maximal activation.

Galpha16 Binding (couple) of nociceptin receptor associated with orphanin and kappa opioid receptor

2) Confidence 0.02 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10334841 Disease Relevance 0 Pain Relevance 0.39

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