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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.77
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
cell groups 1
neurons 1
brains 1
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 16 94.76 High High
Root ganglion neuron 5 77.40 Quite High
Locus ceruleus 26 71.20 Quite High
Neuropathic pain 1 69.84 Quite High
Neuropeptide 8 68.32 Quite High
Sciatic nerve 1 42.64 Quite Low
medulla 5 26.44 Quite Low
Dopamine 5 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 178 93.92 High High
Death 20 93.24 High High
Generalized Anxiety Disorder 2 90.48 High High
Targeted Disruption 101 88.20 High High
Sprains And Strains 25 87.20 High High
Leukemia 8 85.28 High High
Ganglion Cysts 5 77.08 Quite High
Nervous System Injury 1 52.80 Quite High
Disease 9 39.08 Quite Low
Gliosis 2 28.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous report identified HCRT receptor mRNA in the vlPAG of rats [27], but in the present study immunohistochemistry determined that HCRT-2 receptor was present in eGFP/GABA neurons in the mouse vlPAG (Figure 7D).
Transcription (identified) of HCRT receptor in neurons associated with gaba
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.80 Pain Relevance 0.19
This factor, IGFBP3, is only expressed at high levels in a few neuronal cell groups besides hypocretin cells, and regulates hypocretin transcription.
Transcription (transcription) of hypocretin in cell groups
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.42 Pain Relevance 0
In situ hybridization (ISH) studies have shown disappearance of HCRT mRNA in the perifornical area of narcoleptic brains.
Transcription (disappearance) of HCRT in brains
3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.68 Pain Relevance 0.03
These findings were supported by parallel analysis of prepro-galanin messenger RNA levels, where similar transcript levels and effects in the various cultures were observed in the non-radioactive in situ hybridization experiments.
Transcription (levels) of prepro-galanin
4) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10362300 Disease Relevance 0.87 Pain Relevance 0.23

General Comments

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