INT82266

Context Info Confidence 0.68 First Reported 1999 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.77 Pain Relevance 0.46

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)

Anatomy Link Frequency cell groups 1 neurons 1 brains 1 Hcrt (Mus musculus)

Pain Link Frequency Relevance Heat gABA 16 94.76 Root ganglion neuron 5 77.40 Locus ceruleus 26 71.20 Neuropathic pain 1 69.84 Neuropeptide 8 68.32 Sciatic nerve 1 42.64 medulla 5 26.44 Dopamine 5 5.00 amygdala 4 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Sleep Disorders 178 93.92 Death 20 93.24 Generalized Anxiety Disorder 2 90.48 Targeted Disruption 101 88.20 Sprains And Strains 25 87.20 Leukemia 8 85.28 Ganglion Cysts 5 77.08 Nervous System Injury 1 52.80 Disease 9 39.08 Gliosis 2 28.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A previous report identified HCRT receptor mRNA in the vlPAG of rats [27], but in the present study immunohistochemistry determined that HCRT-2 receptor was present in eGFP/GABA neurons in the mouse vlPAG (Figure 7D).

Transcription (identified) of HCRT receptor in neurons associated with gaba

1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.80 Pain Relevance 0.19

This factor, IGFBP3, is only expressed at high levels in a few neuronal cell groups besides hypocretin cells, and regulates hypocretin transcription.

Transcription (transcription) of hypocretin in cell groups

2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.42 Pain Relevance 0

In situ hybridization (ISH) studies have shown disappearance of HCRT mRNA in the perifornical area of narcoleptic brains.

Transcription (disappearance) of HCRT in brains

3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.68 Pain Relevance 0.03

These findings were supported by parallel analysis of prepro-galanin messenger RNA levels, where similar transcript levels and effects in the various cultures were observed in the non-radioactive in situ hybridization experiments.

Transcription (levels) of prepro-galanin

4) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10362300 Disease Relevance 0.87 Pain Relevance 0.23

General Comments

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