INT8248

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2009
Negated 4
Speculated 4
Reported most in Abstract
Documents 43
Total Number 47
Disease Relevance 6.72
Pain Relevance 22.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
platelet 5
spinal 3
blood 2
adipocytes 2
spinal cord 1
Adra2a (Mus musculus)
Adra2a - T370K (1)
Pain Link Frequency Relevance Heat
Clonidine 99 100.00 Very High Very High Very High
agonist 59 100.00 Very High Very High Very High
opiate 48 100.00 Very High Very High Very High
antagonist 43 100.00 Very High Very High Very High
Opioid 21 100.00 Very High Very High Very High
opioid receptor 21 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
Morphine 26 99.98 Very High Very High Very High
Antinociceptive 8 99.98 Very High Very High Very High
Analgesic 5 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 3 99.48 Very High Very High Very High
Obesity 21 99.40 Very High Very High Very High
Hyperalgesia 6 99.10 Very High Very High Very High
INFLAMMATION 12 98.88 Very High Very High Very High
Targeted Disruption 9 98.84 Very High Very High Very High
Convulsion 5 98.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

7 98.42 Very High Very High Very High
Nervous System Injury 5 97.92 Very High Very High Very High
Schizophrenia 6 97.84 Very High Very High Very High
Pressure And Volume Under Development 1 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation was mediated by binding to the alpha 2 adrenergic receptor.
alpha 2 Binding (binding) of
1) Confidence 0.48 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8982098 Disease Relevance 0 Pain Relevance 0.23
Quinidine is effective in decreasing specific [3H]clonidine binding to the alpha 2 receptor within the range of therapeutic blood levels (Ki = 6 x 10 (-8) M).
alpha 2 receptor Binding (binding) of in blood associated with clonidine
2) Confidence 0.46 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6249628 Disease Relevance 0 Pain Relevance 0.44
Taken together, these findings suggest that modulation of receptor function as a result of physical associations between delta opiate receptors and alpha2A-adrenoceptors may account for the observed synergy between opiate and adrenergic agonists in spinal analgesia.
alpha2A-adrenoceptors Binding (associations) of in spinal associated with agonist, opiate and analgesia
3) Confidence 0.39 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.78
The specific binding of tritiated (3H)-clonidine, an alpha 2-adrenergic receptor agonist, to platelet membranes was measured in normal subjects and in patients with major depressive disorder.
2-adrenergic Binding (binding) of in platelet associated with depression, agonist and clonidine
4) Confidence 0.38 Published 1981 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 6274267 Disease Relevance 0.23 Pain Relevance 0.33
However, because of the complexity of multiple alpha2-AR subtypes and their distribution, the exact role of this receptor in modulating seizure activity is not clear. alpha2A- and alpha2C-ARs function as both autoreceptors (presynaptic) on noradrenergic neurons, where they regulate norepinephrine (NE) release, and as postsynaptic receptors on neurons that receive noradrenergic innervation, where they regulate the release of other neurotransmitters (heteroreceptor).
alpha2-AR Spec (clear) Binding (complexity) of in neurons associated with neurotransmitter and convulsion
5) Confidence 0.37 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183527 Disease Relevance 0.26 Pain Relevance 0.29
To differentiate conceivable alpha2-adrenoceptor subtype specific interactions the authors analyzed wild-type mice and knock-out mice with deletion of the alpha2A-, alpha2B-, or alpha2C-adrenoceptor.
alpha2-adrenoceptor Binding (interactions) of associated with targeted disruption
6) Confidence 0.37 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18580178 Disease Relevance 0.10 Pain Relevance 0.22
The current study examined the analgesic interaction between two intrathecally injected alpha2-adrenergic receptor (AR) agonists previously thought to act at the same receptor subtype when given spinally.
alpha2-adrenergic receptor Spec (examined) Binding (interaction) of associated with analgesic and agonist
7) Confidence 0.36 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19212267 Disease Relevance 0 Pain Relevance 0.48
The specific binding to isolated platelet membranes of 3H-clonidine, an alpha 2-adrenergic receptor partial agonist, and 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, was measured in male, drug-free schizophrenic patients.
alpha 2-adrenergic Spec (partial) Binding (binding) of in platelet associated with antagonist, agonist, schizophrenia and clonidine
8) Confidence 0.36 Published 1984 Journal Psychiatry Res Section Abstract Doc Link 6087398 Disease Relevance 0.17 Pain Relevance 0.27
The specific binding to isolated platelet membranes of 3H-clonidine, an alpha 2-adrenergic receptor partial agonist, and 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, was measured in male, drug-free schizophrenic patients.
alpha 2-adrenergic Spec (partial) Binding (binding) of in platelet associated with antagonist, agonist, schizophrenia and clonidine
9) Confidence 0.36 Published 1984 Journal Psychiatry Res Section Abstract Doc Link 6087398 Disease Relevance 0.17 Pain Relevance 0.26
These results indicate that endogenous noradrenaline is involved in the apparent antagonistic interaction between selective alpha2-adrenoceptor antagonists and 5-HT2 receptor antagonists in the head-twitch response, and suggest that noradrenaline stimulation of alpha1-adrenoceptors may be involved in this apparent antagonism.
alpha2-adrenoceptor Binding (interaction) of in head associated with antagonist and noradrenaline
10) Confidence 0.35 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077577 Disease Relevance 0 Pain Relevance 0.53
Finally, using receptor activity mediated neurite outgrowth in Neuro 2A cells as a physiological readout, we found that interactions between delta opiate receptors and alpha2A-adrenoceptors have functional consequences.
alpha2A-adrenoceptors Binding (interactions) of in neurite associated with opiate
11) Confidence 0.34 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.85
Using coimmunoprecipitation of differentially epitope-tagged receptors, we found that delta opiate receptors exist in interacting complexes with alpha2A-adrenoceptors in heterologous cells. 4.
alpha2A-adrenoceptors Binding (complexes) of associated with opiate
12) Confidence 0.34 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.67
Using coimmunoprecipitation of differentially epitope-tagged receptors, we found that delta opiate receptors exist in interacting complexes with alpha2A-adrenoceptors in heterologous cells. 4.
alpha2A-adrenoceptors Binding (interacting) of associated with opiate
13) Confidence 0.34 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.67
It is concluded that yohimbine and other alpha 2-adrenoceptor antagonists inhibit the stimulation-evoked release of [3H]GABA through a mechanism which appears to be independent of the blockade of alpha 2-adrenoceptors and which does not involve an interaction with endogenous noradrenaline.
2-adrenoceptor Neg (not) Binding (interaction) of associated with gaba, antagonist and noradrenaline
14) Confidence 0.32 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990943 Disease Relevance 0 Pain Relevance 0.84
On the other hand, the non imidazoline ligand 3H-rauwolscine binds only to the alpha 2-adrenergic receptors with a maximal density of 155 +/- 28 fmol/mg of protein and a Kd of 11.5 +/- 1.5 nM.
alpha 2-adrenergic Binding (binds) of
15) Confidence 0.31 Published 1989 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2573323 Disease Relevance 0 Pain Relevance 0.35
Several studies have reported functional interactions between different subtypes of opioid and alpha2A-adrenoceptors in the induction of spinal cord analgesia.
alpha2A-adrenoceptors Binding (interactions) of in spinal cord associated with opioid, analgesia and spinal cord
16) Confidence 0.30 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.35
This study was undertaken to evaluate the antinociceptive interactions of alpha 2 adrenergic and opiate receptors at the spinal level.
alpha 2 Binding (interactions) of in spinal associated with opiate and antinociceptive
17) Confidence 0.26 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2537587 Disease Relevance 0.09 Pain Relevance 1.20
Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.
alpha 2 Binding (interactions) of in spinal associated with agonist, opiate and antinociceptive
18) Confidence 0.22 Published 1989 Journal Anesth. Analg. Section Title Doc Link 2537587 Disease Relevance 0.09 Pain Relevance 2.10
Diversity in study design, assessment and reporting of outcomes limited the extent of quantitative analysis.Alpha2-adrenergic agonists are more effective than placebo in ameliorating withdrawal, and despite higher rates of adverse effects, are associated with significantly higher rates of completion of treatment.For the comparison of alpha2-adrenergic agonist regimes with reducing doses of methadone, there were insufficient data for statistical analysis, but withdrawal intensity appears similar to or marginally greater with alpha2-adrenergic agonists, while signs and symptoms of withdrawal occur and resolve earlier.
Alpha2-adrenergic Binding (associated) of
19) Confidence 0.21 Published 2009 Journal Cochrane Database Syst Rev Section Body Doc Link 19370574 Disease Relevance 0 Pain Relevance 0
The Thr370Lys alpha2B AR-Galpha protein interactions may modify the tertiary structure of the mutant receptor in such a way that some putative alpha2 AR antagonists are capable of stabilizing an active receptor conformation, thereby generating positive efficacy.
alpha2B AR (T370K) Binding (interactions) of associated with antagonist
20) Confidence 0.21 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617142 Disease Relevance 0 Pain Relevance 0.24

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