INT82798

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 12.06
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
T-cell 1
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 62 100.00 Very High Very High Very High
cytokine 11 100.00 Very High Very High Very High
Arthritis 1 89.36 High High
Paracetamol 248 87.36 High High
agonist 31 86.72 High High
Angina 1 81.24 Quite High
cINOD 14 73.24 Quite High
depression 17 67.48 Quite High
opioid receptor 19 65.36 Quite High
fibrosis 1 59.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 200 100.00 Very High Very High Very High
INFLAMMATION 71 100.00 Very High Very High Very High
Adhesions 12 100.00 Very High Very High Very High
Chromosomal Instability 1 99.92 Very High Very High Very High
Colon Cancer 76 99.78 Very High Very High Very High
Malignant Neoplastic Disease 27 99.78 Very High Very High Very High
Lymphatic System Cancer 91 99.12 Very High Very High Very High
Necrosis 10 99.12 Very High Very High Very High
Cancer 401 98.94 Very High Very High Very High
Familial Adenomatous Polyposis 9 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no change in the p21waf1/cip1 and c-myc protein levels in the MKN28 cells.
Neg (no) Regulation (change) of c-myc
1) Confidence 0.60 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.88 Pain Relevance 0.11
B may also work in a pro-apoptotic way by regulating 'interferon-regulated factor-1', the oncogene c-myc, p53 and caspase-1.
Regulation (regulating) of c-myc associated with apoptosis
2) Confidence 0.60 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.60 Pain Relevance 0
Some of these miRNAs mediate key mRNA targets such as Ras, E2F5, c-myc, eIF5A, and PP2B.
Regulation (targets) of c-myc
3) Confidence 0.60 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.73 Pain Relevance 0
TCF-regulated genes, including c-Myc and NOS2, were also increased by expression of ?
Regulation (regulated) of c-Myc
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.11 Pain Relevance 0
B [39] as well as the down-regulation of c-Myc [40].
Regulation (regulation) of c-Myc
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.68
The down-regulation of c-Myc may be an important function of Ifit-3 as previous studies have demonstrated that c-Myc expression can impair the IFN response and in particular, suppress the NF-?
Regulation (regulation) of c-Myc
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.68
These cells should allow c-Myc–I148E-CXCR2-C352I G?
Regulation (allow) of c-Myc
7) Confidence 0.44 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.11 Pain Relevance 0.08
between the c-myc gene on chromosome
Regulation (between) of c-myc
8) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.53 Pain Relevance 0
A triple function of PLA2-derived lipid mediators has been suggested: causing immediate inflammatory signs, involvement in secondary processes, e.g., superoxide free radical (O2) generation, apoptosis, or tumour necrosis factor-alpha (TNF-alpha)-cytotoxicity, and controlling the expression and activation of pivotal proteins implicated in inflammation and cell development, e.g., cytokines, adhesion proteins, proteinases, NF-kappaB, fos/jun/AP-1, c-Myc, or p21ras.
Regulation (controlling) of c-Myc associated with necrosis, inflammation, cancer, apoptosis, adhesions and cytokine
9) Confidence 0.44 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989628 Disease Relevance 0.84 Pain Relevance 0.31
We did not detect C-MYC gene rearrangement or BCL-2 expression.
Neg (not) Regulation (detect) of C-MYC
10) Confidence 0.44 Published 2005 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 15588855 Disease Relevance 1.17 Pain Relevance 0.08
Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers, directly target the proto-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling.
Regulation (target) of c-myc in T-cell associated with colon cancer and familial adenomatous polyposis
11) Confidence 0.44 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.36 Pain Relevance 0
We confirmed the effect of PS on six significantly up-regulated genes (YWHAH, TM4SF1, MYC, DCTPP1, BLM and BRIP1) and four significantly down-regulated genes (RCAN2, ROBO2, CYP7B1, and ITGB8) using QPCR (Figure 4).
Regulation (effect) of MYC
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.13 Pain Relevance 0
VPA appears to induce an increase in the amount of p21WAF1 protein over 48 hours in AML cells, which is independent of p53 levels (whose expression is not modulated by VPA), but appears to be dependent on c-myc, whose mRNA and protein levels decrease in a dose-dependent manner during VPA treatment.
Regulation (dependent) of c-myc associated with myeloid leukemia
13) Confidence 0.26 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.63 Pain Relevance 0.06
The mRNA and protein levels of p53, p21waf1/cip1, and c-myc were determined by Northern and Western blotting.
Spec (determined) Regulation (determined) of c-myc
14) Confidence 0.26 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.97 Pain Relevance 0.14
Furthermore, in adenomas, a down-regulation of APC after treatment and a tight correlation of the expressions of the two Wnt targets, c-myc and cyclin D1, in both stages of treatment were observed.
Regulation (targets) of c-myc
15) Confidence 0.26 Published 2002 Journal Anticancer Res. Section Body Doc Link 12174906 Disease Relevance 0.08 Pain Relevance 0
It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene.
Regulation (deregulation) of myc associated with malignant neoplastic disease
16) Confidence 0.26 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1904237 Disease Relevance 0.46 Pain Relevance 0
Further, these studies exhibited a series of mechanistic information including free radical scavenging ability, anti-endonucleolytic activity, cytochrome P450 2E1 inhibitory activity, anti-necrotic, anti-apoptotic and anti-carcinogenic activities, modulatory effects on antioxidative and apoptotic regulatory genes such as Bcl2, c-myc and p53, which may be responsible for the novel chemoprotective properties exhibited by GSPE.
Regulation (effects) of c-myc associated with apoptosis
17) Confidence 0.26 Published 2002 Journal Indian J. Exp. Biol. Section Abstract Doc Link 12587719 Disease Relevance 0.58 Pain Relevance 0.07
It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene.
Regulation (deregulation) of myc associated with malignant neoplastic disease
18) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 0.91 Pain Relevance 0
Genes involved in the cell cycle process such as the protooncogene c-myc, cyclins and p21 are regulated by this mechanism.
Regulation (regulated) of protooncogene c-myc
19) Confidence 0.12 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.42 Pain Relevance 0.10
They sought to determine whether Myc-induced up-regulation of the miR-17-92 cluster is directly responsible for the down regulation of these anti-angiogenic factors.
Spec (whether) Regulation (regulation) of Myc
20) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.79 Pain Relevance 0

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