INT82803

Context Info Confidence 0.57 First Reported 1999 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.57 Pain Relevance 0.81

cell adhesion (ITGA4) plasma membrane (ITGA4)

Anatomy Link Frequency pancreas 2 melanocyte 2 hippocampus 2 ITGA4 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 2 99.84 GABAergic 1 99.12 gABA 3 98.44 Chronic pancreatitis 2 97.76 medulla 1 89.64 tetrodotoxin 1 86.08 Pyramidal cell 1 78.96 melanocortin 1 receptor 2 75.00 Glutamate 1 54.76 Potency 1 15.88

Disease Link Frequency Relevance Heat Pancreatic Cancer 2 99.20 Familial Dysautonomia 75 97.80 Pancreatitis 2 97.76 Adenocarcinoma 2 88.92 Cognitive Disorder 7 75.04 Dementia 4 71.12 Toxicity 5 62.36 Attention Deficit Hyperactivity Disorder 2 48.96 Disorder Of Lipid Metabolism 1 12.92 Congenital Anomalies 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that the beta4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of beta4 integrin subunit protein in pancreas associated with pancreatic cancer and chronic pancreatitis

1) Confidence 0.57 Published 2005 Journal J. Histochem. Cytochem. Section Abstract Doc Link 15928331 Disease Relevance 0.54 Pain Relevance 0.20

We sought substances already proven safe for clinical use that would increase the levels of wild-type IKAP mRNA in cell lines created from cells taken from FD patients in order to identify potential treatments.

Positive_regulation (increase) of Gene_expression (levels) of wild-type associated with familial dysautonomia

2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 1.03 Pain Relevance 0

E2 increased levels of the alpha 4 subunit in hippocampus via an increase in the GABA-modulatory progesterone metabolite 3 alpha-OH-5 alpha-pregnan-20-one.

Positive_regulation (increased) of Gene_expression (levels) of alpha 4 subunit in hippocampus associated with gaba and hippocampus

3) Confidence 0.02 Published 2000 Journal Novartis Found. Symp. Section Abstract Doc Link 10965507 Disease Relevance 0 Pain Relevance 0.47

Expression of the Val60Leu, Arg142His, Arg151Cys, Arg160Trp, and Asp294His receptors in COS 1 cells revealed that these receptors were unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation.

Neg (unable) Positive_regulation (stimulate) of Gene_expression (production) of wild type receptor in melanocyte

4) Confidence 0.02 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10403794 Disease Relevance 0 Pain Relevance 0.15

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