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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.57
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
Anatomy Link Frequency
pancreas 2
melanocyte 2
hippocampus 2
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 2 99.84 Very High Very High Very High
GABAergic 1 99.12 Very High Very High Very High
gABA 3 98.44 Very High Very High Very High
Chronic pancreatitis 2 97.76 Very High Very High Very High
medulla 1 89.64 High High
tetrodotoxin 1 86.08 High High
Pyramidal cell 1 78.96 Quite High
melanocortin 1 receptor 2 75.00 Quite High
Glutamate 1 54.76 Quite High
Potency 1 15.88 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2 99.20 Very High Very High Very High
Familial Dysautonomia 75 97.80 Very High Very High Very High
Pancreatitis 2 97.76 Very High Very High Very High
Adenocarcinoma 2 88.92 High High
Cognitive Disorder 7 75.04 Quite High
Dementia 4 71.12 Quite High
Toxicity 5 62.36 Quite High
Attention Deficit Hyperactivity Disorder 2 48.96 Quite Low
Disorder Of Lipid Metabolism 1 12.92 Low Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the beta4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of beta4 integrin subunit protein in pancreas associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.57 Published 2005 Journal J. Histochem. Cytochem. Section Abstract Doc Link 15928331 Disease Relevance 0.54 Pain Relevance 0.20
We sought substances already proven safe for clinical use that would increase the levels of wild-type IKAP mRNA in cell lines created from cells taken from FD patients in order to identify potential treatments.
Positive_regulation (increase) of Gene_expression (levels) of wild-type associated with familial dysautonomia
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 1.03 Pain Relevance 0
E2 increased levels of the alpha 4 subunit in hippocampus via an increase in the GABA-modulatory progesterone metabolite 3 alpha-OH-5 alpha-pregnan-20-one.
Positive_regulation (increased) of Gene_expression (levels) of alpha 4 subunit in hippocampus associated with gaba and hippocampus
3) Confidence 0.02 Published 2000 Journal Novartis Found. Symp. Section Abstract Doc Link 10965507 Disease Relevance 0 Pain Relevance 0.47
Expression of the Val60Leu, Arg142His, Arg151Cys, Arg160Trp, and Asp294His receptors in COS 1 cells revealed that these receptors were unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation.
Neg (unable) Positive_regulation (stimulate) of Gene_expression (production) of wild type receptor in melanocyte
4) Confidence 0.02 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10403794 Disease Relevance 0 Pain Relevance 0.15

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